ENSGALG00000010560


Gallus gallus

Features
Gene ID: ENSGALG00000010560
  
Biological name :EIF2AK2
  
Synonyms : EIF2AK2 / interferon-induced, double-stranded RNA-activated protein kinase
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 2 alpha kinase 2 / P19525 / Q03963
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 32072407
Gene end: 32090400
  
Corresponding Affymetrix probe sets: Gga.9292.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017163
NCBI entrez gene - 395147     See in Manteia.
RefSeq - XM_015283612
RefSeq - NM_204487
RefSeq - XM_015283610
RefSeq - XM_015283611
RefSeq Peptide - NP_989818
swissprot - F1NLD7
Ensembl - ENSGALG00000010560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2ak2ENSDARG00000068729Danio rerio
 pkzENSDARG00000052396Danio rerio
 P19525ENSG00000055332Homo sapiens
 Q03963ENSMUSG00000024079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF2AK3 / eukaryotic translation initiation factor 2 alpha kinase 3 / Q9NZJ5*ENSGALG0000001595823
EIF2AK4 / eukaryotic translation initiation factor 2 alpha kinase 4 / Q9P2K8* / Q9QZ05* / eIF-2-alpha kinase GCN2 *ENSGALG0000000961120
EIF2AK1 / eukaryotic translation initiation factor 2-alpha kinase 1 / Q9BQI3* / Q9Z2R9*ENSGALG0000000339118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014720  Double-stranded RNA-binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR033366  Interferon-induced, double-stranded RNA-activated protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0035455 response to interferon-alpha IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:1900225 regulation of NLRP3 inflammasome complex assembly IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation IEA
 biological_processGO:1902033 regulation of hematopoietic stem cell proliferation IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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