ENSGALG00000015958


Gallus gallus

Features
Gene ID: ENSGALG00000015958
  
Biological name :EIF2AK3
  
Synonyms : EIF2AK3 / eukaryotic translation initiation factor 2 alpha kinase 3
  
Possible biological names infered from orthology : Q9NZJ5
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 86677824
Gene end: 86696746
  
Corresponding Affymetrix probe sets: GgaAffx.10171.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025668
NCBI entrez gene - 422930     See in Manteia.
RefSeq - XM_420868
swissprot - E1BX69
Ensembl - ENSGALG00000015958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2ak3ENSDARG00000062139Danio rerio
 Q9NZJ5ENSG00000172071Homo sapiens
 Eif2ak3ENSMUSG00000031668Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF2AK1 / eukaryotic translation initiation factor 2-alpha kinase 1 / Q9BQI3* / Q9Z2R9*ENSGALG0000000339116
EIF2AK4 / eukaryotic translation initiation factor 2 alpha kinase 4 / Q9P2K8* / Q9QZ05* / eIF-2-alpha kinase GCN2 *ENSGALG0000000961116
EIF2AK2 / interferon-induced, double-stranded RNA-activated protein kinase / P19525* / Q03963* / eukaryotic translation initiation factor 2 alpha kinase 2*ENSGALG0000001056014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006983 ER overload response IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0070417 cellular response to cold IEA
 biological_processGO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
PERK regulates gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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