ENSDARG00000068729


Danio rerio

Features
Gene ID: ENSDARG00000068729
  
Biological name :eif2ak2
  
Synonyms : eif2ak2 / eukaryotic translation initiation factor 2-alpha kinase 2
  
Possible biological names infered from orthology : Interferon-induced, double-stranded RNA-activated protein kinase / P19525 / Q03963
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 50207943
Gene end: 50234122
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133369
NCBI entrez gene - 100001092     See in Manteia.
RefSeq - NM_001114470
RefSeq Peptide - NP_001107942
swissprot - F1RAF5
swissprot - A0A0R4IHF6
ZFIN ID - ZDB-GENE-080422-1
Ensembl - ENSDARG00000068729
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EIF2AK2ENSGALG00000010560Gallus gallus
 P19525ENSG00000055332Homo sapiens
 Q03963ENSMUSG00000024079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eif2ak3 / eukaryotic translation initiation factor 2-alpha kinase 3 / Q9NZJ5*ENSDARG0000006213925
pkz / protein kinase containing Z-DNA binding domains / P19525* / EIF2AK2* / eukaryotic translation initiation factor 2 alpha kinase 2*ENSDARG0000005239621
eif2ak1 / eukaryotic translation initiation factor 2-alpha kinase 1 / Q9BQI3* / Q9Z2R9*ENSDARG0000009318217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014720  Double-stranded RNA-binding domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045087 innate immune response IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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