5610


Homo sapiens (NCBI)

Features
Gene ID: 5610
  
Biological name :
  
Synonyms : EIF2AK1|PKR|PPP1R83|PRKR / EIF2AK2 / eukaryotic translation initiation factor 2 alpha kinase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 204211_x_at (Human Genome U133 Plus 2.0 Array)   213294_at (Human Genome U133 Plus 2.0 Array)   242898_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034615254
RefSeq - 208431827
RefSeq - 208431829
RefSeq - 4506103
RefSeq - 767914900
RefSeq - NC_000002.12
RefSeq - NG_030351.1
RefSeq - NP_001129123.1
RefSeq - NP_001129124.1
RefSeq - NP_002750.1
RefSeq - XP_011531289.1
RefSeq - XP_016859992.1
RefSeq - NM_001135651.2
RefSeq - NM_001135652.2
RefSeq - NM_002759.3
RefSeq - XM_017004503.1
RefSeq - XM_011532987.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000055332 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IMP
 biological_processGO:0001819 positive regulation of cytokine production ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030683 evasion or tolerance by virus of host immune response TAS
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0032722 positive regulation of chemokine production ISS
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade ISS
 biological_processGO:0033689 negative regulation of osteoblast proliferation IMP
 biological_processGO:0034198 cellular response to amino acid starvation IMP
 biological_processGO:0035455 response to interferon-alpha IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:1900225 regulation of NLRP3 inflammasome complex assembly ISS
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISS
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation ISS
 biological_processGO:1902033 regulation of hematopoietic stem cell proliferation ISS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0022626 cytosolic ribosome IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IMP
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity TAS
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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