13666


Mus musculus (NCBI)

Features
Gene ID: 13666
  
Biological name :
  
Synonyms : Eif2ak3 / eukaryotic translation initiation factor 2 alpha kinase 3 / Pek|Perk
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1430371_x_at (Mouse Genome 430 2.0 Array)   1449278_at (Mouse Genome 430 2.0 Array)   1453505_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 124001564
RefSeq - 568940585
RefSeq - 755516066
RefSeq - 927028879
RefSeq - NC_000072.6
RefSeq - NP_001300847.1
RefSeq - NP_034251.2
RefSeq - XP_006505564.1
RefSeq - XP_011239504.1
RefSeq - NM_001313918.1
RefSeq - NM_010121.3
RefSeq - XM_006505501.1
RefSeq - XM_011241202.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000031668 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001503 ossification ISO
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0006412 translation IDA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0006983 ER overload response ISO
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007029 endoplasmic reticulum organization IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0009967 positive regulation of signal transduction IDA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0019217 regulation of fatty acid metabolic process IMP
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response ISO
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development ISO
 biological_processGO:0031642 negative regulation of myelination IMP
 biological_processGO:0032055 negative regulation of translation in response to stress ISO
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0032933 SREBP signaling pathway IDA
 biological_processGO:0034198 cellular response to amino acid starvation ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress ISO
 biological_processGO:0036499 PERK-mediated unfolded protein response IMP
 biological_processGO:0042149 cellular response to glucose starvation ISO
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IMP
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0070417 cellular response to cold ISO
 biological_processGO:1900182 positive regulation of protein localization to nucleus IMP
 biological_processGO:1902010 negative regulation of translation in response to endoplasmic reticulum stress IDA
 biological_processGO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
 biological_processGO:1903788 positive regulation of glutathione biosynthetic process IMP
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0022626 cytosolic ribosome IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0051879 Hsp90 protein binding ISO
 molecular_functionGO:0071074 eukaryotic initiation factor eIF2 binding IC


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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