ENSMUSG00000021116


Mus musculus

Features
Gene ID: ENSMUSG00000021116
  
Biological name :Eif2s1
  
Synonyms : Eif2s1 / Eukaryotic translation initiation factor 2 subunit 1 / Q6ZWX6
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 2 subunit alpha / P05198
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 78861819
Gene end: 78887010
  
Corresponding Affymetrix probe sets: 10396795 (MoGene1.0st)   1420491_at (Mouse Genome 430 2.0 Array)   1452662_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071214
NCBI entrez gene - 13665     See in Manteia.
MGI - MGI:95299
RefSeq - NM_026114
RefSeq Peptide - NP_080390
swissprot - Q6ZWX6
Ensembl - ENSMUSG00000021116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2s1aENSDARG00000005827Danio rerio
 eif2s1bENSDARG00000052178Danio rerio
 EIF2S1ENSGALG00000009565Gallus gallus
 EIF2S1ENSG00000134001Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003029  S1 domain
 IPR011488  Translation initiation factor 2, alpha subunit
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022967  RNA-binding domain, S1
 IPR024054  Translation initiation factor 2, alpha subunit, middle domain superfamily
 IPR024055  Translation initiation factor 2, alpha subunit, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IDA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0032057 negative regulation of translational initiation in response to stress IDA
 biological_processGO:0034198 cellular response to amino acid starvation IDA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0043558 regulation of translational initiation in response to stress IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1905098 negative regulation of guanyl-nucleotide exchange factor activity IEA
 biological_processGO:1990737 response to manganese-induced endoplasmic reticulum stress IEA
 biological_processGO:2000676 positive regulation of type B pancreatic cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005840 ribosome IBA
 cellular_componentGO:0005850 eukaryotic translation initiation factor 2 complex IEA
 cellular_componentGO:0005851 eukaryotic translation initiation factor 2B complex IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0033290 eukaryotic 48S preinitiation complex IBA
 cellular_componentGO:0043614 multi-eIF complex IBA
 cellular_componentGO:0044207 translation initiation ternary complex IEA
 cellular_componentGO:0097451 glial limiting end-foot IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043022 ribosome binding IEA


Pathways (from Reactome)
Pathway description
PERK regulates gene expression
ABC-family proteins mediated transport
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
Recycling of eIF2:GDP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2s1tm1Rjk/Eif2s1+,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038762 Abcf1 / Q6P542 / ATP-binding cassette, sub-family F (GCN20), member 1 / Q8NE71* / ATP binding cassette subfamily F member 1*  / complex / reaction
 ENSMUSG00000031668 Eif2ak3 / eukaryotic translation initiation factor 2 alpha kinase 3 / Q9NZJ5*  / reaction
 ENSMUSG00000069049 Q9Z0N2 / Eif2s3y / Eukaryotic translation initiation factor 2 subunit 3, Y-linked / EIF2S3* / P41091* / Q2VIR3* / EIF2S3B* / eukaryotic translation initiation factor 2 subunit gamma* / euk...  / complex
 ENSMUSG00000074656 Eif2s2 / Q99L45 / Eukaryotic translation initiation factor 2 subunit 2 / P20042* / eukaryotic translation initiation factor 2 subunit beta*  / complex
 ENSMUSG00000035150 Q9Z0N1 / Eif2s3x / Eukaryotic translation initiation factor 2 subunit 3, X-linked / EIF2S3* / P41091* / Q2VIR3* / EIF2S3B* / eukaryotic translation initiation factor 2 subunit gamma* / euk...  / complex






 

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