ENSMUSG00000069049


Mus musculus

Features
Gene ID: ENSMUSG00000069049
  
Biological name :Eif2s3y
  
Synonyms : Eif2s3y / Eukaryotic translation initiation factor 2 subunit 3, Y-linked / Q9Z0N2
  
Possible biological names infered from orthology : EIF2S3 / EIF2S3B / eukaryotic translation initiation factor 2 subunit gamma / eukaryotic translation initiation factor 2 subunit gamma B / P41091 / Q2VIR3
  
Species: Mus musculus
  
Chr. number: Y
Strand: 1
Band: A1
Gene start: 1010543
Gene end: 1028847
  
Corresponding Affymetrix probe sets: 10608001 (MoGene1.0st)   1417210_at (Mouse Genome 430 2.0 Array)   1431642_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088736
NCBI entrez gene - 26908     See in Manteia.
MGI - MGI:1349430
RefSeq - XM_011248593
RefSeq - NM_012011
RefSeq - XM_006531608
RefSeq - XM_006531609
RefSeq Peptide - NP_036141
swissprot - Q9Z0N2
Ensembl - ENSMUSG00000069049
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2s3ENSDARG00000008292Danio rerio
 EIF2S3ENSGALG00000016340Gallus gallus
 EIF2S3ENSG00000130741Homo sapiens
 Q2VIR3ENSG00000180574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z0N1 / Eif2s3x / Eukaryotic translation initiation factor 2 subunit 3, X-linked / EIF2S3* / P41091* / Q2VIR3* / EIF2S3B* / eukaryotic translation initiation factor 2 subunit gamma* / euk...ENSMUSG0000003515098


Protein motifs (from Interpro)
Interpro ID Name
 IPR000795  Transcription factor, GTP-binding domain
 IPR004161  Translation elongation factor EFTu-like, domain 2
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR009001  Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
 IPR015256  Translation initiation factor 2, gamma subunit, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 cellular_componentGO:0005850 eukaryotic translation initiation factor 2 complex ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
Recycling of eIF2:GDP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038762 Abcf1 / Q6P542 / ATP-binding cassette, sub-family F (GCN20), member 1 / Q8NE71* / ATP binding cassette subfamily F member 1*  / reaction / complex
 ENSMUSG00000021116 Eif2s1 / Q6ZWX6 / Eukaryotic translation initiation factor 2 subunit 1 / P05198* / eukaryotic translation initiation factor 2 subunit alpha*  / complex
 ENSMUSG00000074656 Eif2s2 / Q99L45 / Eukaryotic translation initiation factor 2 subunit 2 / P20042* / eukaryotic translation initiation factor 2 subunit beta*  / complex






 

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