ENSMUSG00000074656


Mus musculus

Features
Gene ID: ENSMUSG00000074656
  
Biological name :Eif2s2
  
Synonyms : Eif2s2 / Eukaryotic translation initiation factor 2 subunit 2 / Q99L45
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 2 subunit beta / P20042
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 154871410
Gene end: 154892935
  
Corresponding Affymetrix probe sets: 10488806 (MoGene1.0st)   10578683 (MoGene1.0st)   1417712_at (Mouse Genome 430 2.0 Array)   1417713_at (Mouse Genome 430 2.0 Array)   1441023_at (Mouse Genome 430 2.0 Array)   1448819_at (Mouse Genome 430 2.0 Array)   1448820_a_at (Mouse Genome 430 2.0 Array)   1456617_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128257
Ensembl peptide - ENSMUSP00000096777
Ensembl peptide - ENSMUSP00000125248
NCBI entrez gene - 67204     See in Manteia.
MGI - MGI:1914454
RefSeq - NM_026030
RefSeq Peptide - NP_080306
swissprot - E0CXJ3
swissprot - Q3ULL5
swissprot - Q99L45
Ensembl - ENSMUSG00000074656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2s2ENSDARG00000053047Danio rerio
 EIF2S2ENSGALG00000033196Gallus gallus
 EIF2S2ENSG00000125977Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002735  Translation initiation factor IF2/IF5
 IPR016189  Translation initiation factor IF2/IF5, N-terminal
 IPR016190  Translation initiation factor IF2/IF5, zinc-binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0002176 male germ cell proliferation IMP
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0008584 male gonad development IMP
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005850 eukaryotic translation initiation factor 2 complex ISO
 molecular_functionGO:0003743 translation initiation factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
Recycling of eIF2:GDP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp8a2wl/Atp8a2+
Genetic Background: Not Specified

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
Show

Allelic Composition: Atp8a2wl/Atp8a2+
Genetic Background: Not Specified

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2wl/Atp8a2+
Genetic Background: Not Specified

 MP:0008390 abnormal primordial germ cell proliferation "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2wl/Atp8a2+
Genetic Background: Not Specified

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Atp8a2wl/Atp8a2+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038762 Abcf1 / Q6P542 / ATP-binding cassette, sub-family F (GCN20), member 1 / Q8NE71* / ATP binding cassette subfamily F member 1*  / reaction / complex
 ENSMUSG00000021116 Eif2s1 / Q6ZWX6 / Eukaryotic translation initiation factor 2 subunit 1 / P05198* / eukaryotic translation initiation factor 2 subunit alpha*  / complex
 ENSMUSG00000035150 Q9Z0N1 / Eif2s3x / Eukaryotic translation initiation factor 2 subunit 3, X-linked / EIF2S3* / P41091* / Q2VIR3* / EIF2S3B* / eukaryotic translation initiation factor 2 subunit gamma* / euk...  / complex
 ENSMUSG00000069049 Q9Z0N2 / Eif2s3y / Eukaryotic translation initiation factor 2 subunit 3, Y-linked / EIF2S3* / P41091* / Q2VIR3* / EIF2S3B* / eukaryotic translation initiation factor 2 subunit gamma* / euk...  / complex






 

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