ENSG00000125977


Homo sapiens

Features
Gene ID: ENSG00000125977
  
Biological name :EIF2S2
  
Synonyms : EIF2S2 / eukaryotic translation initiation factor 2 subunit beta / P20042
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.22
Gene start: 34088298
Gene end: 34112332
  
Corresponding Affymetrix probe sets: 208725_at (Human Genome U133 Plus 2.0 Array)   208726_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364119
NCBI entrez gene - 8894     See in Manteia.
OMIM - 603908
RefSeq - NM_003908
RefSeq - XM_017028118
RefSeq - NM_001316363
RefSeq - NM_001316364
RefSeq Peptide - NP_001303293
RefSeq Peptide - NP_003899
RefSeq Peptide - NP_001303292
swissprot - P20042
swissprot - Q6IBR8
Ensembl - ENSG00000125977
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2s2ENSDARG00000053047Danio rerio
 EIF2S2ENSGALG00000033196Gallus gallus
 Eif2s2ENSMUSG00000074656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002735  Translation initiation factor IF2/IF5
 IPR016189  Translation initiation factor IF2/IF5, N-terminal
 IPR016190  Translation initiation factor IF2/IF5, zinc-binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0002176 male germ cell proliferation IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0055085 transmembrane transport TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005850 eukaryotic translation initiation factor 2 complex TAS
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003743 translation initiation factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
ABC-family proteins mediated transport
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Recycling of eIF2:GDP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / complex
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / complex
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / reaction
 ENSG00000106682 EIF4H / Q15056 / eukaryotic translation initiation factor 4H  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000204574 ABCF1 / Q8NE71 / ATP binding cassette subfamily F member 1  / reaction / complex
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / reaction
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr