ENSG00000063046


Homo sapiens

Features
Gene ID: ENSG00000063046
  
Biological name :EIF4B
  
Synonyms : EIF4B / eukaryotic translation initiation factor 4B / P23588
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 53006158
Gene end: 53042209
  
Corresponding Affymetrix probe sets: 211937_at (Human Genome U133 Plus 2.0 Array)   211938_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448980
Ensembl peptide - ENSP00000450324
Ensembl peptide - ENSP00000449746
Ensembl peptide - ENSP00000262056
Ensembl peptide - ENSP00000388806
Ensembl peptide - ENSP00000412530
Ensembl peptide - ENSP00000447192
Ensembl peptide - ENSP00000448365
Ensembl peptide - ENSP00000448399
NCBI entrez gene - 1975     See in Manteia.
OMIM - 603928
RefSeq - NM_001300821
RefSeq - NM_001417
RefSeq Peptide - NP_001287750
RefSeq Peptide - NP_001408
swissprot - F8VYE9
swissprot - F8W0K0
swissprot - E7EX17
swissprot - P23588
swissprot - F8VP89
swissprot - F8VRU1
swissprot - F8VSC7
swissprot - F8VX11
Ensembl - ENSG00000063046
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4baENSDARG00000017439Danio rerio
 eif4bbENSDARG00000010194Danio rerio
 Eif4bENSMUSG00000058655Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4H / Q15056 / eukaryotic translation initiation factor 4HENSG0000010668217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR033107  Eukaryotic translation initiation factor 4B
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0001731 formation of translation preinitiation complex IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006446 regulation of translational initiation TAS
 biological_processGO:0097010 eukaryotic translation initiation factor 4F complex assembly IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005844 polysome IBA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex TAS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity TAS
 molecular_functionGO:0004386 helicase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0033592 RNA strand annealing activity IBA
 molecular_functionGO:0034057 RNA strand-exchange activity IBA
 molecular_functionGO:0043024 ribosomal small subunit binding IBA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
mTORC1-mediated signalling
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108443 P23443 / RPS6KB1 / ribosomal protein S6 kinase B1  / reaction
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / reaction
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / reaction
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / reaction
 ENSG00000125977 EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta  / reaction
 ENSG00000106682 EIF4H / Q15056 / eukaryotic translation initiation factor 4H  / complex
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / complex
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / complex
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / complex
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex






 

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