ENSG00000108443


Homo sapiens

Features
Gene ID: ENSG00000108443
  
Biological name :RPS6KB1
  
Synonyms : P23443 / ribosomal protein S6 kinase B1 / RPS6KB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q23.1
Gene start: 59893046
Gene end: 59950564
  
Corresponding Affymetrix probe sets: 204171_at (Human Genome U133 Plus 2.0 Array)   211578_s_at (Human Genome U133 Plus 2.0 Array)   226660_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468058
Ensembl peptide - ENSP00000464805
Ensembl peptide - ENSP00000466562
Ensembl peptide - ENSP00000225577
Ensembl peptide - ENSP00000376744
Ensembl peptide - ENSP00000384335
Ensembl peptide - ENSP00000441993
NCBI entrez gene - 6198     See in Manteia.
OMIM - 608938
RefSeq - XM_017024933
RefSeq - NM_001272060
RefSeq - NM_003161
RefSeq - XM_011525101
RefSeq - XM_011525102
RefSeq - XM_011525103
RefSeq - XM_017024929
RefSeq - XM_017024930
RefSeq - XM_017024931
RefSeq - XM_017024932
RefSeq - NM_001272042
RefSeq - NM_001272043
RefSeq - NM_001272044
RefSeq Peptide - NP_001258972
RefSeq Peptide - NP_001258973
RefSeq Peptide - NP_001258989
RefSeq Peptide - NP_003152
RefSeq Peptide - NP_001258971
swissprot - K7ER06
swissprot - P23443
swissprot - K7EIM2
swissprot - K7EMM2
Ensembl - ENSG00000108443
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6kb1aENSDARG00000018399Danio rerio
 rps6kb1bENSDARG00000058230Danio rerio
 RPS6KB1ENSGALG00000005198Gallus gallus
 Q8BSK8ENSMUSG00000020516Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UBS0 / RPS6KB2 / ribosomal protein S6 kinase B2ENSG0000017563465
P51812 / RPS6KA3 / ribosomal protein S6 kinase A3ENSG0000017718942
Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2ENSG0000007124242
Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1ENSG0000011767641
Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6ENSG0000007213340
O75582 / RPS6KA5 / ribosomal protein S6 kinase A5ENSG0000010078439
O75676 / RPS6KA4 / ribosomal protein S6 kinase A4ENSG0000016230238
Q86UX6 / STK32C / serine/threonine kinase 32CENSG0000016575222
Q8WU08 / STK32A / serine/threonine kinase 32AENSG0000016930221
Q9NY57 / STK32B / serine/threonine kinase 32BENSG0000015295319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016238  Ribosomal protein S6 kinase
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0003009 skeletal muscle contraction IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014732 skeletal muscle atrophy IEA
 biological_processGO:0014878 response to electrical stimulus involved in regulation of muscle adaptation IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0031929 TOR signaling IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043201 response to leucine IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0045948 positive regulation of translational initiation IMP
 biological_processGO:0046324 regulation of glucose import IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0048015 phosphatidylinositol-mediated signaling TAS
 biological_processGO:0048633 positive regulation of skeletal muscle tissue growth IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004711 ribosomal protein S6 kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103319 EEF2K / O00418 / eukaryotic elongation factor 2 kinase  / reaction
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000137154 RPS6 / P62753 / ribosomal protein S6  / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction






 

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