ENSG00000162302


Homo sapiens

Features
Gene ID: ENSG00000162302
  
Biological name :RPS6KA4
  
Synonyms : O75676 / ribosomal protein S6 kinase A4 / RPS6KA4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 64359148
Gene end: 64372215
  
Corresponding Affymetrix probe sets: 204632_at (Human Genome U133 Plus 2.0 Array)   230544_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432945
Ensembl peptide - ENSP00000435580
Ensembl peptide - ENSP00000435314
Ensembl peptide - ENSP00000333896
NCBI entrez gene - 8986     See in Manteia.
OMIM - 603606
RefSeq - XM_017018527
RefSeq - NM_001006944
RefSeq - NM_001300802
RefSeq - NM_001318361
RefSeq - NM_003942
RefSeq - XM_005274380
RefSeq Peptide - NP_001287731
RefSeq Peptide - NP_001305290
RefSeq Peptide - NP_003933
RefSeq Peptide - NP_001006945
swissprot - O75676
swissprot - E9PKU3
swissprot - E9PJN1
swissprot - A0A0A6YYC0
Ensembl - ENSG00000162302
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ka4ENSDARG00000044436Danio rerio
 Q9Z2B9ENSMUSG00000024952Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O75582 / RPS6KA5 / ribosomal protein S6 kinase A5ENSG0000010078464
P51812 / RPS6KA3 / ribosomal protein S6 kinase A3ENSG0000017718940
Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2ENSG0000007124239
Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1ENSG0000011767639
Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6ENSG0000007213339
P23443 / RPS6KB1 / ribosomal protein S6 kinase B1ENSG0000010844326
Q9UBS0 / RPS6KB2 / ribosomal protein S6 kinase B2ENSG0000017563426
Q9NY57 / STK32B / serine/threonine kinase 32BENSG0000015295315
Q86UX6 / STK32C / serine/threonine kinase 32CENSG0000016575215
Q8WU08 / STK32A / serine/threonine kinase 32AENSG0000016930214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation TAS
 biological_processGO:0032793 positive regulation of CREB transcription factor activity TAS
 biological_processGO:0033129 positive regulation of histone phosphorylation IMP
 biological_processGO:0035066 positive regulation of histone acetylation IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043987 histone H3-S10 phosphorylation IMP
 biological_processGO:0043988 histone H3-S28 phosphorylation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004711 ribosomal protein S6 kinase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recycling pathway of L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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