ENSG00000117676


Homo sapiens

Features
Gene ID: ENSG00000117676
  
Biological name :RPS6KA1
  
Synonyms : Q15418 / ribosomal protein S6 kinase A1 / RPS6KA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.11
Gene start: 26529761
Gene end: 26575030
  
Corresponding Affymetrix probe sets: 203379_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000383967
Ensembl peptide - ENSP00000403548
Ensembl peptide - ENSP00000436990
Ensembl peptide - ENSP00000435412
Ensembl peptide - ENSP00000434616
Ensembl peptide - ENSP00000433039
Ensembl peptide - ENSP00000432281
Ensembl peptide - ENSP00000431651
Ensembl peptide - ENSP00000355831
Ensembl peptide - ENSP00000363278
Ensembl peptide - ENSP00000363281
Ensembl peptide - ENSP00000363283
NCBI entrez gene - 6195     See in Manteia.
OMIM - 601684
RefSeq - XM_005245966
RefSeq - NM_001006665
RefSeq - NM_001330441
RefSeq - NM_002953
RefSeq Peptide - NP_001317370
RefSeq Peptide - NP_002944
RefSeq Peptide - NP_001006666
swissprot - Q5SVM7
swissprot - E9PPN6
swissprot - Q15418
swissprot - E9PPC1
swissprot - E9PMM7
swissprot - E9PAN7
swissprot - E9PGT3
swissprot - A6NND1
swissprot - Q5SVM6
Ensembl - ENSG00000117676
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ka1ENSDARG00000033437Danio rerio
 P18652ENSGALG00000037136Gallus gallus
 P18653ENSMUSG00000003644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51812 / RPS6KA3 / ribosomal protein S6 kinase A3ENSG0000017718978
Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2ENSG0000007124277
Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6ENSG0000007213371
O75582 / RPS6KA5 / ribosomal protein S6 kinase A5ENSG0000010078442
O75676 / RPS6KA4 / ribosomal protein S6 kinase A4ENSG0000016230240
P23443 / RPS6KB1 / ribosomal protein S6 kinase B1ENSG0000010844329
Q9UBS0 / RPS6KB2 / ribosomal protein S6 kinase B2ENSG0000017563427
Q86UX6 / STK32C / serine/threonine kinase 32CENSG0000016575217
Q9NY57 / STK32B / serine/threonine kinase 32BENSG0000015295316
Q8WU08 / STK32A / serine/threonine kinase 32AENSG0000016930216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030307 positive regulation of cell growth TAS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043555 regulation of translation in response to stress TAS
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress TAS
 biological_processGO:0045597 positive regulation of cell differentiation TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0072574 hepatocyte proliferation ISS
 biological_processGO:2000491 positive regulation of hepatic stellate cell activation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000166484 MAPK7 / Q13164 / mitogen-activated protein kinase 7  / reaction
 ENSG00000172216 CEBPB / P17676 / CCAAT/enhancer binding protein beta  / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction






 

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