ENSG00000100784


Homo sapiens

Features
Gene ID: ENSG00000100784
  
Biological name :RPS6KA5
  
Synonyms : O75582 / ribosomal protein S6 kinase A5 / RPS6KA5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.11
Gene start: 90847862
Gene end: 91060636
  
Corresponding Affymetrix probe sets: 1554319_at (Human Genome U133 Plus 2.0 Array)   1557113_at (Human Genome U133 Plus 2.0 Array)   204633_s_at (Human Genome U133 Plus 2.0 Array)   204635_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479667
Ensembl peptide - ENSP00000451305
Ensembl peptide - ENSP00000451736
Ensembl peptide - ENSP00000402787
Ensembl peptide - ENSP00000442803
Ensembl peptide - ENSP00000450591
NCBI entrez gene - 9252     See in Manteia.
OMIM - 603607
RefSeq - NM_001322231
RefSeq - NM_001322227
RefSeq - NM_001322228
RefSeq - NM_001322229
RefSeq - NM_001322230
RefSeq - NM_001322232
RefSeq - NM_001322233
RefSeq - NM_001322234
RefSeq - NM_001322235
RefSeq - NM_001322236
RefSeq - NM_001322237
RefSeq - NM_001322238
RefSeq - NM_004755
RefSeq - NM_182398
RefSeq - XM_017021786
RefSeq Peptide - NP_004746
RefSeq Peptide - NP_001309165
RefSeq Peptide - NP_001309166
RefSeq Peptide - NP_001309167
RefSeq Peptide - NP_872198
RefSeq Peptide - NP_001309156
RefSeq Peptide - NP_001309157
RefSeq Peptide - NP_001309158
RefSeq Peptide - NP_001309159
RefSeq Peptide - NP_001309160
RefSeq Peptide - NP_001309161
RefSeq Peptide - NP_001309162
RefSeq Peptide - NP_001309163
RefSeq Peptide - NP_001309164
swissprot - O75582
swissprot - H0YJE1
swissprot - G3V2D1
swissprot - G3V4D7
Ensembl - ENSG00000100784
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ka5ENSDARG00000060551Danio rerio
 Q5F3L1ENSGALG00000030580Gallus gallus
 Q8C050ENSMUSG00000021180Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O75676 / RPS6KA4 / ribosomal protein S6 kinase A4ENSG0000016230262
Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2ENSG0000007124239
P51812 / RPS6KA3 / ribosomal protein S6 kinase A3ENSG0000017718939
Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1ENSG0000011767639
Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6ENSG0000007213339
Q9UBS0 / RPS6KB2 / ribosomal protein S6 kinase B2ENSG0000017563425
P23443 / RPS6KB1 / ribosomal protein S6 kinase B1ENSG0000010844325
Q9NY57 / STK32B / serine/threonine kinase 32BENSG0000015295316
Q86UX6 / STK32C / serine/threonine kinase 32CENSG0000016575216
Q8WU08 / STK32A / serine/threonine kinase 32AENSG0000016930216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IDA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity TAS
 biological_processGO:0033129 positive regulation of histone phosphorylation IMP
 biological_processGO:0035066 positive regulation of histone acetylation IMP
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0043987 histone H3-S10 phosphorylation IMP
 biological_processGO:0043988 histone H3-S28 phosphorylation IMP
 biological_processGO:0043990 histone H2A-S1 phosphorylation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IMP
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
CREB phosphorylation
NCAM signaling for neurite out-growth
Recycling pathway of L1
CD209 (DC-SIGN) signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / reaction
 ENSG00000123268 ATF1 / P18846 / activating transcription factor 1  / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction






 

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