ENSGALG00000030580


Gallus gallus

Features
Gene ID: ENSGALG00000030580
  
Biological name :RPS6KA5
  
Synonyms : Q5F3L1 / Ribosomal protein S6 kinase alpha-5 / RPS6KA5
  
Possible biological names infered from orthology : O75582 / Q8C050 / ribosomal protein S6 kinase A5 / ribosomal protein S6 kinase, polypeptide 5
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 44172738
Gene end: 44234823
  
Corresponding Affymetrix probe sets: Gga.14856.1.S1_at (Chicken Array)   GgaAffx.6763.3.S1_s_at (Chicken Array)   GgaAffx.6763.4.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057790
Ensembl peptide - ENSGALP00000047730
NCBI entrez gene - 423408     See in Manteia.
RefSeq - XM_015287449
RefSeq - NM_001012587
RefSeq Peptide - NP_001012605
swissprot - Q5F3L1
swissprot - A0A1D5PXU3
Ensembl - ENSGALG00000030580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ka5ENSDARG00000060551Danio rerio
 O75582ENSG00000100784Homo sapiens
 Q8C050ENSMUSG00000021180Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RPS6KA2 / ribosomal protein S6 kinase A2 / Q15349* / Q9WUT3* / ribosomal protein S6 kinase, polypeptide 2*ENSGALG0000001147339
RPS6KA6 / ribosomal protein S6 kinase A6 / Q9UK32* / ribosomal protein S6 kinase polypeptide 6*ENSGALG0000000709739
P18652 / RPS6KA1L / Ribosomal protein S6 kinase 2 alpha / Q15418* / P18653* / RPS6KA1* / ribosomal protein S6 kinase A1* / ribosomal protein S6 kinase polypeptide 1*ENSGALG0000003713638
RPS6KA3 / ribosomal protein S6 kinase A3 / P18654* / P51812* / ribosomal protein S6 kinase polypeptide 3*ENSGALG0000001640638
RPS6KB1 / ribosomal protein S6 kinase beta-1 / P23443* / Q8BSK8* / ribosomal protein S6 kinase B1* / ribosomal protein S6 kinase, polypeptide 1*ENSGALG0000000519825
STK32B / serine/threonine kinase 32B / Q9JJX8* / Q9NY57* / Serine/threonine-protein kinase 32B *ENSGALG0000002951016
STK32C / serine/threonine kinase 32C / Q86UX6* / Q8QZV4* / Serine/threonine-protein kinase 32C *ENSGALG0000002061515
STK32A / serine/threonine kinase 32A / Q8BGW6* / Q8WU08* / Serine/threonine-protein kinase 32A *ENSGALG0000002919515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0033129 positive regulation of histone phosphorylation IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043987 histone H3-S10 phosphorylation IEA
 biological_processGO:0043988 histone H3-S28 phosphorylation IEA
 biological_processGO:0043990 histone H2A-S1 phosphorylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
CREB phosphorylation
NCAM signaling for neurite out-growth
CD209 (DC-SIGN) signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / reaction
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / reaction
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / reaction
 ENSGALG00000008494 CREB1 / P16220* / Q01147* / cAMP responsive element binding protein 1* / Cyclic AMP-responsive element-binding protein 1 *  / reaction






 

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