ENSGALG00000037136


Gallus gallus

Features
Gene ID: ENSGALG00000037136
  
Biological name :RPS6KA1L
  
Synonyms : P18652 / Ribosomal protein S6 kinase 2 alpha / RPS6KA1L
  
Possible biological names infered from orthology : P18653 / Q15418 / ribosomal protein S6 kinase A1 / ribosomal protein S6 kinase polypeptide 1 / RPS6KA1
  
Species: Gallus gallus
  
Chr. number: 23
Strand: -1
Band:
Gene start: 117566
Gene end: 147202
  
Corresponding Affymetrix probe sets: Gga.9321.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051132
Ensembl peptide - ENSGALP00000054526
Ensembl peptide - ENSGALP00000050392
NCBI entrez gene - 386579     See in Manteia.
RefSeq - XM_015297518
RefSeq - XM_015297514
RefSeq - XM_015297515
RefSeq - XM_015297516
RefSeq - XM_015297517
RefSeq - NM_001109771
RefSeq - XM_015297513
RefSeq Peptide - NP_001103241
swissprot - A0A1D5PNT2
swissprot - A0A1D5PCA5
swissprot - P18652
Ensembl - ENSGALG00000037136
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ka1ENSDARG00000033437Danio rerio
 Q15418ENSG00000117676Homo sapiens
 P18653ENSMUSG00000003644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RPS6KA3 / ribosomal protein S6 kinase A3 / P18654* / P51812* / ribosomal protein S6 kinase polypeptide 3*ENSGALG0000001640677
RPS6KA6 / ribosomal protein S6 kinase A6 / Q9UK32* / ribosomal protein S6 kinase polypeptide 6*ENSGALG0000000709776
RPS6KA2 / ribosomal protein S6 kinase A2 / Q15349* / Q9WUT3* / ribosomal protein S6 kinase, polypeptide 2*ENSGALG0000001147376
Q5F3L1 / RPS6KA5 / Ribosomal protein S6 kinase alpha-5 / Q8C050* / O75582* / ribosomal protein S6 kinase A5* / ribosomal protein S6 kinase, polypeptide 5*ENSGALG0000003058040
RPS6KB1 / ribosomal protein S6 kinase beta-1 / P23443* / Q8BSK8* / ribosomal protein S6 kinase B1* / ribosomal protein S6 kinase, polypeptide 1*ENSGALG0000000519828
STK32B / serine/threonine kinase 32B / Q9JJX8* / Q9NY57* / Serine/threonine-protein kinase 32B *ENSGALG0000002951016
STK32C / serine/threonine kinase 32C / Q86UX6* / Q8QZV4* / Serine/threonine-protein kinase 32C *ENSGALG0000002061516
STK32A / serine/threonine kinase 32A / Q8BGW6* / Q8WU08* / Serine/threonine-protein kinase 32A *ENSGALG0000002919515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:2000491 positive regulation of hepatic stellate cell activation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
CREB phosphorylation through the activation of Ras
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / reaction
 ENSGALG00000008494 CREB1 / P16220* / Q01147* / cAMP responsive element binding protein 1* / Cyclic AMP-responsive element-binding protein 1 *  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr