ENSGALG00000042833


Gallus gallus

Features
Gene ID: ENSGALG00000042833
  
Biological name :MAPK14
  
Synonyms : MAPK14 / mitogen-activated protein kinase 14
  
Possible biological names infered from orthology : P47811 / Q16539
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 139302
Gene end: 149917
  
Corresponding Affymetrix probe sets: GgaAffx.11847.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052690
swissprot - A0A1D5PIQ5
Ensembl - ENSGALG00000042833
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk14bENSDARG00000028721Danio rerio
 Q9DGE2ENSDARG00000000857Danio rerio
 MAPK14ENSG00000112062Homo sapiens
 Mapk14ENSMUSG00000053436Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*ENSGALG0000004002386
MAPK12 / mitogen-activated protein kinase 12 / O08911* / P53778*ENSGALG0000001938469
MAPK13 / mitogen-activated protein kinase 13 / O15264* / Q9Z1B7*ENSGALG0000003096666
MAPK9 / P79996 / Mitogen-activated protein kinase 9 / P45984* / Q9WTU6*ENSGALG0000003909956
MAPK8 / mitogen-activated protein kinase 8 / P45983* / Q91Y86*ENSGALG0000000610954
MAPK10 / Gallus gallus mitogen-activated protein kinase 10 (MAPK10), transcript variant 1, mRNA. / P53779* / mitogen-activated protein kinase 10* / mitogen-activated protein kinase 10 isoform 1x *ENSGALG0000001110953


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IEA
 biological_processGO:0010831 positive regulation of myotube differentiation IEA
 biological_processGO:0014835 myoblast differentiation involved in skeletal muscle regeneration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0031281 positive regulation of cyclase activity IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0038066 p38MAPK cascade IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IEA
 biological_processGO:0090400 stress-induced premature senescence IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 biological_processGO:1905050 positive regulation of metallopeptidase activity IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001184 positive regulation of interleukin-12 secretion IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IEA
 molecular_functionGO:0051525 NFAT protein binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000883 MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2 / P49137* / P49138* / MAP kinase-activated protein kinase 2 *  / complex / reaction
 ENSGALG00000002283 MAPKAPK3 / Gallus gallus mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), mRNA. / Q16644* / Q3UMW7* / MAP kinase-activated protein kinase 3 * / mitogen-activated prot...  / complex / reaction
 ENSGALG00000004743 MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41* / O54992* / Gm42878* / MAP kinase-activated protein kinase 5 *  / complex
 ENSGALG00000004370 MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*  / reaction
 ENSGALG00000014645 MEF2C / myocyte enhancer factor 2C / Q06413* / Q8CFN5* / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA.*  / reaction / complex
 ENSGALG00000041285 MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*  / reaction
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / reaction
 ENSGALG00000042491 P62801 / Histone H4   / reaction
 ENSGALG00000015132 CDH2 / P10288 / Cadherin-2 / P15116* / P19022*  / complex
 ENSGALG00000015152 BOC / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex
 ENSGALG00000002447 CTNNA1 / catenin alpha 1 / P26231* / P35221*  / complex
 ENSGALG00000030040 CDH15 / cadherin 15 / P33146* / P55291*  / complex
 ENSGALG00000005065 P49147 / PLA2G4A / Cytosolic phospholipase A2 Phospholipase A2 Lysophospholipase / P47713* / P47712* / phospholipase A2 group IVA* / phospholipase A2, group IVA (cytosolic, calcium-dependent)*  / reaction
 ENSGALG00000035419 CDON / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex
 ENSGALG00000003875 ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / reaction
 ENSGALG00000030580 Q5F3L1 / RPS6KA5 / Ribosomal protein S6 kinase alpha-5 / Q8C050* / O75582* / ribosomal protein S6 kinase A5* / ribosomal protein S6 kinase, polypeptide 5*  / reaction
 ENSGALG00000032366 MEF2A / myocyte enhancer factor 2A / Q02078* / Q60929* / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA.*  / complex / reaction






 

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