ENSDARG00000000857


Danio rerio

Features
Gene ID: ENSDARG00000000857
  
Biological name :mapk14a
  
Synonyms : mapk14a / mitogen-activated protein kinase 14a / Q9DGE2
  
Possible biological names infered from orthology : MAPK14 / mitogen-activated protein kinase 14 / P47811 / Q16539
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 23826985
Gene end: 23860719
  
Corresponding Affymetrix probe sets: Dr.7930.1.S1_at (Zebrafish Array)   NM_131722_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000147688
Ensembl peptide - ENSDARP00000040361
NCBI entrez gene - 65237     See in Manteia.
RefSeq - NM_131722
RefSeq Peptide - NP_571797
swissprot - B2GPM7
swissprot - Q9DGE2
ZFIN ID - ZDB-GENE-010202-2
Ensembl - ENSDARG00000000857
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK14ENSGALG00000042833Gallus gallus
 MAPK14ENSG00000112062Homo sapiens
 Mapk14ENSMUSG00000053436Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*ENSDARG0000002872192
mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*ENSDARG0000004583671
mapk13 / mitogen-activated protein kinase 13ENSDARG0000005847060
mapk12b / mitogen-activated protein kinase 12b / P53778* / MAPK12* / O08911* / mitogen-activated protein kinase 12*ENSDARG0000000640960
O42376 / mapk12a / mitogen-activated protein kinase 12a / O08911* / MAPK12* / P53778* / mitogen-activated protein kinase 12*ENSDARG0000004202157
zgc:171775ENSDARG0000005838157
mapk9 / mitogen-activated protein kinase 9 / P45984* / Q9WTU6*ENSDARG0000007736447
mapk8a / mitogen-activated protein kinase 8aENSDARG0000003188847
mapk8b / Q9DGD9 / mitogen-activated protein kinase 8bENSDARG0000000987047
mapk10 / mitogen-activated protein kinase 10 / P53779* / mitogen-activated protein kinase 10 isoform 1x *ENSDARG0000010273047
BX324164.5 / MAPK13* / O15264* / mitogen-activated protein kinase 13*ENSDARG0000011014319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010831 positive regulation of myotube differentiation ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0038066 p38MAPK cascade ISS
 biological_processGO:0040016 embryonic cleavage IDA
 biological_processGO:0045663 positive regulation of myoblast differentiation ISS
 biological_processGO:0048696 regulation of collateral sprouting in absence of injury IMP
 biological_processGO:1901741 positive regulation of myoblast fusion ISS
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Oxidative Stress Induced Senescence
CDO in myogenesis
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
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 ZFA:0001462 somite border somite border U-shaped , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell cysteine-type endopeptidase activity decreased occurrence , abnormal
retinal ganglion cell neuron remodeling decreased process quality , abnormal
retinal ganglion cell axon physical object quality , abnormal
retinal ganglion cell axon collateral physical object quality , abnormal
retinal ganglion cell collateral sprouting in absence of injury occurrence , abnormal
retinal ganglion cell axon has extra parts of type retinal ganglion cell presynaptic active zone, abnormal
retinal ganglion cell axon increased branchiness , abnormal
retinal ganglion cell axon collateral increased length , abnormal
retinal ganglion cell collateral sprouting in absence of injury increased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018530 mapkapk2b / mitogen-activated protein kinase-activated protein kinase 2b / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...  / complex / reaction
 ENSDARG00000002552 mapkapk2a / mitogen-activated protein kinase-activated protein kinase 2a / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...  / complex / reaction
 ENSDARG00000068191 cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*  / complex
 ENSDARG00000028082 mapkapk5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41*  / complex
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex
 ENSDARG00000102441 ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*  / complex
 ENSDARG00000013397 bnip2 / BCL2 interacting protein 2 / O54940* / Q12982* / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 *  / complex
 ENSDARG00000017141 pla2g4ab / phospholipase A2, group IVAb (cytosolic, calcium-dependent) / P47713* / P47712* / PLA2G4A* / phospholipase A2 group IVA* / phospholipase A2, group IVA (cytosolic, calcium-dependent)*  / reaction
 ENSDARG00000023903 atf2 / activating transcription factor 2 / P15336* / P16951* / Cyclic AMP-dependent transcription factor ATF-2 *  / reaction
 ENSDARG00000060551 rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / Q8C050* / ribosomal protein S6 kinase A5*  / reaction
 ENSDARG00000105345 zgc:173552  / reaction
 ENSDARG00000024546 pla2g4aa / phospholipase A2, group IVAa (cytosolic, calcium-dependent) / P47713* / P47712* / PLA2G4A* / phospholipase A2 group IVA* / phospholipase A2, group IVA (cytosolic, calcium-dependent)*  / reaction
 ENSDARG00000061328 cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex
 ENSDARG00000024785 B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...  / complex
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / reaction
 ENSDARG00000035187 abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / reaction
 ENSDARG00000009418 mef2cb / myocyte enhancer factor 2cb / MEF2C* / Q8CFN5* / Q06413* / myocyte enhancer factor 2C* / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA.*  / reaction / complex
 ENSDARG00000099184 map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction






 

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