ENSDARG00000102441


Danio rerio

Features
Gene ID: ENSDARG00000102441
  
Biological name :ctnna1
  
Synonyms : catenin (cadherin-associated protein), alpha 1 / ctnna1
  
Possible biological names infered from orthology : catenin alpha 1 / P26231 / P35221
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 34488316
Gene end: 34680956
  
Corresponding Affymetrix probe sets: Dr.8148.1.S1_at (Zebrafish Array)   NM_131456_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000132933
NCBI entrez gene - 30741     See in Manteia.
RefSeq - NM_131456
RefSeq Peptide - NP_571531
swissprot - Q9PVF8
ZFIN ID - ZDB-GENE-991207-24
Ensembl - ENSDARG00000102441
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTNNA1ENSGALG00000002447Gallus gallus
 CTNNA1ENSG00000044115Homo sapiens
 Ctnna1ENSMUSG00000037815Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...ENSDARG0000002478579
vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*ENSDARG0000004496823
ctnnal1 / catenin (cadherin-associated protein), alpha-like 1 / O88327* / Q9UBT7* / Alpha-catulin * / catenin alpha like 1*ENSDARG0000001816222
vcla / vinculin a / VCL* / P18206* / vinculin*ENSDARG0000009869521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR001033  Alpha-catenin
 IPR006077  Vinculin/alpha-catenin
 IPR030047  Alpha E-catenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016342 catenin complex IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Adherens junctions interactions
VEGFR2 mediated vascular permeability
RHO GTPases activate IQGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain central canal increased amount , abnormal
hindbrain neural keel formation process quality , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle morphology , abnormal
fourth ventricle separated from fourth ventricle , abnormal
Show

 ZFA:0000948 rhombomere 3 rhombomere 3 neural keel formation process quality , abnormal
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 ZFA:0001032 rhombomere 4 rhombomere 4 neural keel formation process quality , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , ameliorated
whole organism dead , abnormal
whole organism deformed , abnormal
Show

 ZFA:0001106 pharyngeal pouch pharyngeal pouch adherens junction organization process quality , abnormal
Show

 ZFA:0001477 portion of tissue portion of tissue broken , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell catenin complex spatial pattern , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042021 O42376 / mapk12a / mitogen-activated protein kinase 12a / O08911* / MAPK12* / P53778* / mitogen-activated protein kinase 12*  / complex
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex
 ENSDARG00000045836 mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSDARG00000006409 mapk12b / mitogen-activated protein kinase 12b / P53778* / MAPK12* / O08911* / mitogen-activated protein kinase 12*  / complex
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000013397 bnip2 / BCL2 interacting protein 2 / O54940* / Q12982* / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 *  / complex
 ENSDARG00000068191 cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*  / complex
 ENSDARG00000024785 B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...  / complex
 ENSDARG00000035187 abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSDARG00000059067 jupb / junction plakoglobin b / JUP* / P14923* / Q02257* / junction plakoglobin*  / complex / reaction
 ENSDARG00000102441 ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*  / complex
 ENSDARG00000061328 cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex






 

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