ENSMUSG00000037815


Mus musculus

Features
Gene ID: ENSMUSG00000037815
  
Biological name :Ctnna1
  
Synonyms : Catenin alpha-1 / Ctnna1 / P26231
  
Possible biological names infered from orthology : P35221
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B1
Gene start: 35118888
Gene end: 35254773
  
Corresponding Affymetrix probe sets: 10454786 (MoGene1.0st)   1436631_at (Mouse Genome 430 2.0 Array)   1437275_at (Mouse Genome 430 2.0 Array)   1437807_x_at (Mouse Genome 430 2.0 Array)   1448149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049007
NCBI entrez gene - 12385     See in Manteia.
MGI - MGI:88274
RefSeq - XM_011246818
RefSeq - NM_009818
RefSeq - XM_006525548
RefSeq Peptide - NP_033948
swissprot - Q545R0
swissprot - P26231
Ensembl - ENSMUSG00000037815
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctnna1ENSDARG00000102441Danio rerio
 CTNNA1ENSGALG00000002447Gallus gallus
 CTNNA1ENSG00000044115Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*ENSMUSG0000006306382
Ctnna3 / Q65CL1 / Catenin alpha-3 / Q9UI47*ENSMUSG0000006084358
Vcl / Q64727 / vinculin / P18206*ENSMUSG0000002182323
O88327 / Ctnnal1 / Alpha-catulin / Q9UBT7* / catenin alpha like 1*ENSMUSG0000003881622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR001033  Alpha-catenin
 IPR006077  Vinculin/alpha-catenin
 IPR030047  Alpha E-catenin
 IPR036723  Alpha-catenin/vinculin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IMP
 biological_processGO:0007406 negative regulation of neuroblast proliferation IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016264 gap junction assembly IEA
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043297 apical junction assembly IMP
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IGI
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0071681 cellular response to indole-3-methanol IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IMP
 biological_processGO:2000146 negative regulation of cell motility IMP
 biological_processGO:2001045 negative regulation of integrin-mediated signaling pathway IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005915 zonula adherens IDA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0016600 flotillin complex IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0017166 vinculin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Adherens junctions interactions
VEGFR2 mediated vascular permeability
RHO GTPases activate IQGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0000448 pointed snout "nose tapers to a small tip, sharper angle than wild type " [J:18378]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0001230 epidermal desquamation "shedding of the cuticle of the epidermis in scales or shreds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(Wap-cre)11738Mam/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

Allelic Composition: Ctnna1Gt(fVET3A)Hiir/Ctnna1Gt(fVET3A)Hiir
Genetic Background: involves: C3H * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ

 MP:0003420 delayed intramembranous bone ossification "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(Wap-cre)11738Mam/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129X1/SvJ * FVB

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(Wap-cre)11738Mam/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129X1/SvJ * FVB

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(Wap-cre)11738Mam/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0009715 thick epidermis stratum basale "increased thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0010172 abnormal mammary gland epithelium physiology "any functional anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0010236 abnormal retina outer limiting membrane morphology "any structural anomaly of the row of junctional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0012040 abnormal c wave shape "any anomaly in the graphical representation of the c wave in the electroretinogram; the ERG c-wave can be used to assess the functional integrity of the photoreceptors, the pigment epithelial cells and the interactions between them." [http:webvision.med.utah.edu/book/electrophysiology/the-electroretinogram-erg/, MGI:csmith]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0012671 retinal spots "the appearance of roundish lesions on the retina, frequently white, and may be due to inflammation, degeneration, vasculitis, exudates, edema or mineral deposits" [MGI:csmith]
Show

Allelic Composition: Prkcdtm1.1Chou/Prkcdtm1.1Chou
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129X1/SvJ * FVB

Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,Tg(Wap-cre)11738Mam/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000303 Cdh1 / cadherin 1 / P12830*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / complex
 ENSMUSG00000020859 Spag9 / Q58A65 / sperm associated antigen 9 / O60271*  / complex
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction
 ENSMUSG00000101645 P30999 / Gm28635 / predicted gene 28635 / O60716* / CTNND1* / catenin delta 1*  / complex / reaction
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000024947 Men1 / Menin / O88559 / O00255* / menin 1*  / complex / reaction
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000030536 Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*  / reaction / complex
 ENSMUSG00000001552 Jup / Q02257 / Junction plakoglobin / P14923*  / complex / reaction
 ENSMUSG00000031871 Cdh5 / P55284 / Cadherin-5 / P33151*  / complex
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / reaction / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex
 ENSMUSG00000022610 Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*  / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / complex
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr