ENSMUSG00000060843


Mus musculus

Features
Gene ID: ENSMUSG00000060843
  
Biological name :Ctnna3
  
Synonyms : Catenin alpha-3 / Ctnna3 / Q65CL1
  
Possible biological names infered from orthology : Q9UI47
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 63430098
Gene end: 65003667
  
Corresponding Affymetrix probe sets: 10363676 (MoGene1.0st)   1441193_at (Mouse Genome 430 2.0 Array)   1441560_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074606
Ensembl peptide - ENSMUSP00000101080
Ensembl peptide - ENSMUSP00000101081
NCBI entrez gene - 216033     See in Manteia.
MGI - MGI:2661445
RefSeq - XM_006513475
RefSeq - NM_001164376
RefSeq - NM_001164519
RefSeq - NM_177612
RefSeq Peptide - NP_001157991
RefSeq Peptide - NP_808280
RefSeq Peptide - NP_001157848
swissprot - Q65CL1
Ensembl - ENSMUSG00000060843
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTNNA3ENSGALG00000002845Gallus gallus
 CTNNA3ENSG00000183230Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*ENSMUSG0000006306360
Ctnna1 / P26231 / Catenin alpha-1 / P35221*ENSMUSG0000003781559
O88327 / Ctnnal1 / Alpha-catulin / Q9UBT7* / catenin alpha like 1*ENSMUSG0000003881621
Vcl / Q64727 / vinculin / P18206*ENSMUSG0000002182321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001033  Alpha-catenin
 IPR006077  Vinculin/alpha-catenin
 IPR030044  Alpha T-catenin
 IPR036723  Alpha-catenin/vinculin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
 biological_processGO:0086091 regulation of heart rate by cardiac conduction ISO
 biological_processGO:0098609 cell-cell adhesion IDA
 biological_processGO:0098911 regulation of ventricular cardiac muscle cell action potential ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005916 fascia adherens ISS
 cellular_componentGO:0030027 lamellipodium IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0045296 cadherin binding TAS
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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