ENSMUSG00000063063


Mus musculus

Features
Gene ID: ENSMUSG00000063063
  
Biological name :Ctnna2
  
Synonyms : Ctnna2 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / Q61301
  
Possible biological names infered from orthology : catenin alpha 2 / P26232
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 76881637
Gene end: 77979699
  
Corresponding Affymetrix probe sets: 10545538 (MoGene1.0st)   1448895_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124764
Ensembl peptide - ENSMUSP00000124689
Ensembl peptide - ENSMUSP00000144890
Ensembl peptide - ENSMUSP00000074809
Ensembl peptide - ENSMUSP00000123714
Ensembl peptide - ENSMUSP00000124376
NCBI entrez gene - 12386     See in Manteia.
MGI - MGI:88275
RefSeq - XM_017321372
RefSeq - NM_001109764
RefSeq - NM_001355193
RefSeq - NM_009819
RefSeq - NM_145732
RefSeq - XM_011241194
RefSeq - XM_011241195
RefSeq - XM_017321371
RefSeq Peptide - NP_033949
RefSeq Peptide - NP_663785
RefSeq Peptide - NP_001103234
RefSeq Peptide - NP_001342122
swissprot - Q8BS72
swissprot - E0CXB9
swissprot - A0A0N4SUZ7
swissprot - Q61301
Ensembl - ENSMUSG00000063063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B7ZC77ENSDARG00000024785Danio rerio
 ENSGALG00000015966Gallus gallus
 CTNNA2ENSGALG00000027853Gallus gallus
 CTNNA2ENSG00000066032Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctnna1 / P26231 / Catenin alpha-1 / P35221*ENSMUSG0000003781578
Ctnna3 / Q65CL1 / Catenin alpha-3 / Q9UI47*ENSMUSG0000006084357
Vcl / Q64727 / vinculin / P18206*ENSMUSG0000002182323
O88327 / Ctnnal1 / Alpha-catulin / Q9UBT7* / catenin alpha like 1*ENSMUSG0000003881621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR001033  Alpha-catenin
 IPR006077  Vinculin/alpha-catenin
 IPR030046  Alpha N-catenin
 IPR036723  Alpha-catenin/vinculin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0021942 radial glia guided migration of Purkinje cell IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0051823 regulation of synapse structural plasticity IMP
 biological_processGO:0060134 prepulse inhibition IMP
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 biological_processGO:0098609 cell-cell adhesion ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IMP
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0004812 abnormal linear vestibular evoked potential "anomaly in the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head); normally, this response is measured by electrophysiological activity of the peripheral vestibular nerve; this assesses the function of the gravity receptor system including the utricles and saccules of the inner ear" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2ho-4J/Grid2ho-4J
Genetic Background: DBA/2J-Grid2ho-4J/J

 MP:0004814 reduced linear vestibular evoked potential "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0009971 decreased hippocampus pyramidal cell number "decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0010011 ectopic hippocampus pyramidal cells "the hippocampus pyramidal cell body resides in places other than the pyramidal cell layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / complex
 ENSMUSG00000020859 Spag9 / Q58A65 / sperm associated antigen 9 / O60271*  / complex
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / complex
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / reaction / complex
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000022610 Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*  / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / complex
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex / reaction






 

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