ENSMUSG00000011958


Mus musculus

Features
Gene ID: ENSMUSG00000011958
  
Biological name :Bnip2
  
Synonyms : BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Bnip2 / O54940
  
Possible biological names infered from orthology : BCL2 interacting protein 2 / Q12982
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 69989466
Gene end: 70008317
  
Corresponding Affymetrix probe sets: 10586759 (MoGene1.0st)   1422490_at (Mouse Genome 430 2.0 Array)   1422491_a_at (Mouse Genome 430 2.0 Array)   1431731_at (Mouse Genome 430 2.0 Array)   1433025_x_at (Mouse Genome 430 2.0 Array)   1441989_at (Mouse Genome 430 2.0 Array)   1453993_a_at (Mouse Genome 430 2.0 Array)   1454441_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082513
Ensembl peptide - ENSMUSP00000117957
Ensembl peptide - ENSMUSP00000034754
Ensembl peptide - ENSMUSP00000133200
Ensembl peptide - ENSMUSP00000113466
Ensembl peptide - ENSMUSP00000115106
NCBI entrez gene - 12175     See in Manteia.
MGI - MGI:109327
RefSeq - XM_006510793
RefSeq - XM_006510789
RefSeq - XM_006510791
RefSeq - NM_001008238
RefSeq - NM_016787
RefSeq Peptide - NP_058067
RefSeq Peptide - NP_001008239
swissprot - O54940
swissprot - Q91VL0
swissprot - F6VF29
swissprot - D6RE50
swissprot - G5E8U9
Ensembl - ENSMUSG00000011958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bnip2ENSDARG00000013397Danio rerio
 BNIP2ENSGALG00000003788Gallus gallus
 BNIP2ENSG00000140299Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
2 / Prune2 / Q52KR3 / Q8WUY3* / prune homolog 2*ENSMUSG0000003912653
Atcay / Q8BHE3 / Caytaxin / Q86WG3* / ATCAY, caytaxin*ENSMUSG0000003495851
Bnipl / Q99JU7 / Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein / Q7Z465* / BCL2 interacting protein like*ENSMUSG0000002811544
Q5FWK3 / Arhgap1 / Rho GTPase-activating protein 1 / Q07960*ENSMUSG0000002724725
Q9CXP4 / Arhgap8 / Rho GTPase-activating protein 8 / P85298* / PRR5-ARHGAP8* / PRR5-ARHGAP8 readthrough*ENSMUSG0000007895417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR022181  Bcl2-/adenovirus E1B 19kDa-interacting protein 2
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006915 apoptotic process IBA
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IMP
 biological_processGO:0051146 striated muscle cell differentiation IGI
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005814 centriole IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031616 spindle pole centrosome IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0042802 identical protein binding IBA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0012768 decreased KLRG1-positive NK cell number "decrease in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0013025 increased Ly6C low monocyte number "increase in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0013155 decreased KLRG1+ CD8 alpha beta T cell number "decrease in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [MGI:csmith]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / complex
 ENSMUSG00000020859 Spag9 / Q58A65 / sperm associated antigen 9 / O60271*  / complex
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / complex
 ENSMUSG00000006699 Cdc42 / P60766 / Cell division control   / complex / reaction
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000033022 Cdo1 / P60334 / Cysteine dioxygenase type 1 / Q16878*  / complex / reaction
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / complex
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex
 ENSMUSG00000022610 Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*  / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / complex
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex






 

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