ENSG00000140299


Homo sapiens

Features
Gene ID: ENSG00000140299
  
Biological name :BNIP2
  
Synonyms : BCL2 interacting protein 2 / BNIP2 / Q12982
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q22.2
Gene start: 59659146
Gene end: 59689534
  
Corresponding Affymetrix probe sets: 209308_s_at (Human Genome U133 Plus 2.0 Array)   226280_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479818
Ensembl peptide - ENSP00000393644
Ensembl peptide - ENSP00000267859
Ensembl peptide - ENSP00000412767
Ensembl peptide - ENSP00000475320
Ensembl peptide - ENSP00000398364
NCBI entrez gene - 663     See in Manteia.
OMIM - 603292
RefSeq - NM_004330
RefSeq - NM_001320674
RefSeq - NM_001320675
RefSeq Peptide - NP_001307603
RefSeq Peptide - NP_004321
RefSeq Peptide - NP_001307604
swissprot - Q12982
swissprot - H7C096
swissprot - H7C142
swissprot - J3KN59
Ensembl - ENSG00000140299
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bnip2ENSDARG00000013397Danio rerio
 BNIP2ENSGALG00000003788Gallus gallus
 Bnip2ENSMUSG00000011958Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRUNE2 / Q8WUY3 / prune homolog 2ENSG0000010677248
ATCAY / Q86WG3 / ATCAY, caytaxinENSG0000016765440
BNIPL / Q7Z465 / BCL2 interacting protein likeENSG0000016314134
Q07960 / ARHGAP1 / Rho GTPase activating protein 1ENSG0000017522018
PRR5-ARHGAP8 / PRR5-ARHGAP8 readthroughENSG0000024840515
P85298 / ARHGAP8 / Rho GTPase activating protein 8ENSG0000024148413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR022181  Bcl2-/adenovirus E1B 19kDa-interacting protein 2
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0006915 apoptotic process IPI
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031616 spindle pole centrosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IBA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188130 MAPK12 / P53778 / mitogen-activated protein kinase 12  / reaction / complex
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / complex / reaction
 ENSG00000008294 SPAG9 / O60271 / sperm associated antigen 9  / reaction / complex
 ENSG00000064309 CDON / Q4KMG0 / cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000170558 CDH2 / P19022 / cadherin 2  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000066032 CTNNA2 / P26232 / catenin alpha 2  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000144857 BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulated  / reaction / complex
 ENSG00000129910 CDH15 / P55291 / cadherin 15  / reaction / complex
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / complex / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / complex / reaction






 

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