ENSG00000188130


Homo sapiens

Features
Gene ID: ENSG00000188130
  
Biological name :MAPK12
  
Synonyms : MAPK12 / mitogen-activated protein kinase 12 / P53778
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.33
Gene start: 50245450
Gene end: 50261825
  
Corresponding Affymetrix probe sets: 1556340_at (Human Genome U133 Plus 2.0 Array)   1556341_s_at (Human Genome U133 Plus 2.0 Array)   206106_at (Human Genome U133 Plus 2.0 Array)   226672_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379124
Ensembl peptide - ENSP00000479972
Ensembl peptide - ENSP00000379126
Ensembl peptide - ENSP00000215659
NCBI entrez gene - 6300     See in Manteia.
OMIM - 602399
RefSeq - NM_002969
RefSeq - NM_001303252
RefSeq Peptide - NP_001290181
RefSeq Peptide - NP_002960
swissprot - P53778
swissprot - B5MDL5
swissprot - A8MY48
Ensembl - ENSG00000188130
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk12bENSDARG00000006409Danio rerio
 O42376ENSDARG00000042021Danio rerio
 MAPK12ENSGALG00000019384Gallus gallus
 Mapk12ENSMUSG00000022610Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK13 / O15264 / mitogen-activated protein kinase 13ENSG0000015671165
MAPK11 / Q15759 / mitogen-activated protein kinase 11ENSG0000018538662
MAPK14 / Q16539 / mitogen-activated protein kinase 14ENSG0000011206261
MAPK10 / P53779 / mitogen-activated protein kinase 10ENSG0000010933947
MAPK8 / P45983 / mitogen-activated protein kinase 8ENSG0000010764347
MAPK9 / P45984 / mitogen-activated protein kinase 9ENSG0000005074847


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007517 muscle organ development TAS
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010952 positive regulation of peptidase activity NAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation TAS
 biological_processGO:0045445 myoblast differentiation IDA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
p38MAPK events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
CDO in myogenesis
DSCAM interactions
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / reaction
 ENSG00000144857 BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000081189 MEF2C / Q06413 / myocyte enhancer factor 2C  / complex / reaction
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000066032 CTNNA2 / P26232 / catenin alpha 2  / reaction / complex
 ENSG00000064309 CDON / Q4KMG0 / cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000170558 CDH2 / P19022 / cadherin 2  / reaction / complex
 ENSG00000071564 TCF3 / P15923 / transcription factor 3  / reaction
 ENSG00000140299 BNIP2 / Q12982 / BCL2 interacting protein 2  / reaction / complex
 ENSG00000068305 MEF2A / Q02078 / myocyte enhancer factor 2A  / reaction / complex
 ENSG00000008294 SPAG9 / O60271 / sperm associated antigen 9  / complex / reaction
 ENSG00000129910 CDH15 / P55291 / cadherin 15  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex






 

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