ENSDARG00000006409


Danio rerio

Features
Gene ID: ENSDARG00000006409
  
Biological name :mapk12b
  
Synonyms : mapk12b / mitogen-activated protein kinase 12b
  
Possible biological names infered from orthology : MAPK12 / mitogen-activated protein kinase 12 / O08911 / P53778
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 5523690
Gene end: 5530441
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000020408
NCBI entrez gene - 557810     See in Manteia.
RefSeq - NM_001044841
RefSeq Peptide - NP_001038306
swissprot - Q5RHW0
ZFIN ID - ZDB-GENE-041210-123
Ensembl - ENSDARG00000006409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK12ENSGALG00000019384Gallus gallus
 MAPK12ENSG00000188130Homo sapiens
 Mapk12ENSMUSG00000022610Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O42376 / mapk12a / mitogen-activated protein kinase 12a / O08911* / MAPK12* / P53778* / mitogen-activated protein kinase 12*ENSDARG0000004202174
mapk13 / mitogen-activated protein kinase 13ENSDARG0000005847065
mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*ENSDARG0000002872160
Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*ENSDARG0000000085760
mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*ENSDARG0000004583658
zgc:171775ENSDARG0000005838155
mapk10 / mitogen-activated protein kinase 10 / P53779* / mitogen-activated protein kinase 10 isoform 1x *ENSDARG0000010273046
mapk8a / mitogen-activated protein kinase 8aENSDARG0000003188845
mapk9 / mitogen-activated protein kinase 9 / P45984* / Q9WTU6*ENSDARG0000007736445
mapk8b / Q9DGD9 / mitogen-activated protein kinase 8bENSDARG0000000987043
BX324164.5 / MAPK13* / O15264* / mitogen-activated protein kinase 13*ENSDARG0000011014317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
CDO in myogenesis
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex
 ENSDARG00000024785 B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...  / complex
 ENSDARG00000061328 cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex
 ENSDARG00000009418 mef2cb / myocyte enhancer factor 2cb / MEF2C* / Q8CFN5* / Q06413* / myocyte enhancer factor 2C* / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA.*  / reaction / complex
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex
 ENSDARG00000068191 cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*  / complex
 ENSDARG00000013397 bnip2 / BCL2 interacting protein 2 / O54940* / Q12982* / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 *  / complex
 ENSDARG00000035187 abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSDARG00000102441 ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*  / complex






 

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