Manteia - Molecule gene

ENSMUSG00000022610

Mus musculus

Features

Gene ID:	ENSMUSG00000022610

Biological name :	Mapk12

Synonyms :	Mapk12 / Mitogen-activated protein kinase 12 / O08911

Possible biological names infered from orthology :	P53778

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	E3
Gene start:	89130584
Gene end:	89140703

Corresponding Affymetrix probe sets:	10431393 (MoGene1.0st) 1447823_x_at (Mouse Genome 430 2.0 Array) 1449283_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000086207 NCBI entrez gene - 29857 See in Manteia. MGI - MGI:1353438 RefSeq - XM_006521060 RefSeq - NM_013871 RefSeq - XM_006521058 RefSeq - XM_006521059 RefSeq Peptide - NP_038899 swissprot - O08911 Ensembl - ENSMUSG00000022610

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mapk12b	ENSDARG00000006409	Danio rerio
O42376	ENSDARG00000042021	Danio rerio
MAPK12	ENSGALG00000019384	Gallus gallus
MAPK12	ENSG00000188130	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mapk13 / Q9Z1B7 / Mitogen-activated protein kinase 13 / O15264*	ENSMUSG00000004864	65
Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*	ENSMUSG00000053137	62
Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*	ENSMUSG00000053436	60
Mapk10 / mitogen-activated protein kinase 10 isoform 1x / P53779* / mitogen-activated protein kinase 10*	ENSMUSG00000046709	48
Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*	ENSMUSG00000021936	48
Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*	ENSMUSG00000020366	47

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
IPR008352	Mitogen-activated protein (MAP) kinase p38-like
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0010468	regulation of gene expression	IBA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018105	peptidyl-serine phosphorylation	IEA
biological_process	GO:0045445	myoblast differentiation	IEA
biological_process	GO:0045786	negative regulation of cell cycle	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0005739	mitochondrion	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0000287	magnesium ion binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	TAS
molecular_function	GO:0004707	MAP kinase activity	IBA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

NOD1/2 Signaling Pathway

CDO in myogenesis

DSCAM interactions

VEGFA-VEGFR2 Pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: B2m^tm1Unc/B2m^tm1Unc,H2-D1^tm1Bpe/H2-D1^tm1Bpe Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Mapk12^tm1Cnd/Mapk12^tm1Cnd,Mapk13^tm1Cnd/Mapk13^tm1Cnd Genetic Background: Not Specified
MP:0005602	decreased angiogenesis	"reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]	Show Allelic Composition: Lrp6^tm1.2Cjz/Lrp6^Gt(Ex187)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL
MP:0006039	decreased mitochondrial proliferation	"less than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp6^tm1.2Cjz/Lrp6^Gt(Ex187)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000026842	Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*	/ complex
ENSMUSG00000022687	Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*	/ complex
ENSMUSG00000038119	Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*	/ complex
ENSMUSG00000063063	Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*	/ complex
ENSMUSG00000031962	Cdh15 / P33146 / Cadherin-15 / P55291*	/ complex
ENSMUSG00000024304	Cdh2 / P15116 / Cadherin-2 / P19022*	/ complex
ENSMUSG00000011958	Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*	/ complex
ENSMUSG00000029167	O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*	/ reaction
ENSMUSG00000020859	Spag9 / Q58A65 / sperm associated antigen 9 / O60271*	/ complex
ENSMUSG00000005583	Mef2c / Q8CFN5 / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413* / myocyte enhancer factor 2C*	/ reaction / complex
ENSMUSG00000037815	Ctnna1 / P26231 / Catenin alpha-1 / P35221*	/ complex
ENSMUSG00000006932	Ctnnb1 / Q02248 / Catenin beta-1 / P35222*	/ complex
ENSMUSG00000030557	Mef2a / Q60929 / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078* / myocyte enhancer factor 2A*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr