ENSMUSG00000020366


Mus musculus

Features
Gene ID: ENSMUSG00000020366
  
Biological name :Mapk9
  
Synonyms : Mapk9 / Mitogen-activated protein kinase 9 / Q9WTU6
  
Possible biological names infered from orthology : P45984
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.2
Gene start: 49846751
Gene end: 49886421
  
Corresponding Affymetrix probe sets: 10375634 (MoGene1.0st)   1421876_at (Mouse Genome 430 2.0 Array)   1421877_at (Mouse Genome 430 2.0 Array)   1421878_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136977
Ensembl peptide - ENSMUSP00000042744
Ensembl peptide - ENSMUSP00000099839
Ensembl peptide - ENSMUSP00000104807
Ensembl peptide - ENSMUSP00000020634
Ensembl peptide - ENSMUSP00000104808
Ensembl peptide - ENSMUSP00000132864
NCBI entrez gene - 26420     See in Manteia.
MGI - MGI:1346862
RefSeq - XM_017314563
RefSeq - NM_001163671
RefSeq - NM_001163672
RefSeq - NM_016961
RefSeq - NM_207692
RefSeq - XM_017314562
RefSeq Peptide - NP_058657
RefSeq Peptide - NP_997575
RefSeq Peptide - NP_001157143
RefSeq Peptide - NP_001157144
swissprot - Q5NCK8
swissprot - Q9WTU6
Ensembl - ENSMUSG00000020366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk9ENSDARG00000077364Danio rerio
 MAPK9ENSGALG00000039099Gallus gallus
 MAPK9ENSG00000050748Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk10 / mitogen-activated protein kinase 10 isoform 1x / P53779* / mitogen-activated protein kinase 10*ENSMUSG0000004670985
Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*ENSMUSG0000002193682
Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*ENSMUSG0000005343642
Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*ENSMUSG0000005313742
Mapk13 / Q9Z1B7 / Mitogen-activated protein kinase 13 / O15264*ENSMUSG0000000486441
Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*ENSMUSG0000002261041


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008351  Mitogen-activated protein (MAP) kinase, JNK
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007254 JNK cascade IBA
 biological_processGO:0007258 JUN phosphorylation IEA
 biological_processGO:0009612 response to mechanical stimulus IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0034614 cellular response to reactive oxygen species ISO
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0046686 response to cadmium ion IGI
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0061833 protein localization to tricellular tight junction IMP
 biological_processGO:0071276 cellular response to cadmium ion ISO
 biological_processGO:0071310 cellular response to organic substance IBA
 biological_processGO:0071803 positive regulation of podosome assembly IMP
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004705 JUN kinase activity IBA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000478 delayed intestine development "slowed progression to a structurally mature intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gba2tm1Rus/Gba2tm1Rus
Genetic Background: involves: 129S6/SvEv * C57BL/6J

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0001051 abnormal somatic motor system morphology 
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Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp3tm1.2Ics/Parp3tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapk10tm1Flv/Mapk10tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: B6.129S-Mapk9tm1Flv Mapk10tm1Flv

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov
Genetic Background: Not Specified

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov
Genetic Background: Not Specified

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mapk9tm1Flv/Mapk9tm1Flv,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0004778 increased foam cell number "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gba2tm1Rus/Gba2tm1Rus
Genetic Background: involves: 129S6/SvEv * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk9tm1Flv/Mapk9tm1Flv,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0006257 abnormal fungiform papillae "malformation, absence, or atypical size or shape of the mushroom-shaped papillae, which have a single tase bud at the tip, located mostly on the dorsal anterior portion of the tongue " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr1Crsh/Celsr1Scy
Genetic Background: involves: 101/H * BALB/c * C3H/He * C3H/HeH

 MP:0008113 abnormal macrophage differentiation "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0009604 increased keratohyalin granule number "increased size of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gba2tm1Rus/Gba2tm1Rus
Genetic Background: involves: 129S6/SvEv * C57BL/6J

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0010715 coloboma of the retina "congenital defect of the retina in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Mapk10tm1Flv/Mapk10tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: B6.129S-Mapk9tm1Flv Mapk10tm1Flv

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011709 increased fibroblast cell migration "greater frequency of or more rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012261 increased hindbrain apoptosis "increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0012502 decreased hindbrain apoptosis "decrease in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0012504 increased forebrain apoptosis "increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0012677 absent brain ventricles "absence of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002948 Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*  / reaction
 ENSMUSG00000052684 Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*  / reaction
 ENSMUSG00000027104 Atf2 / P16951 / Cyclic AMP-dependent transcription factor ATF-2 / P15336* / activating transcription factor 2*  / reaction
 ENSMUSG00000033352 Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*  / reaction






 

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