ENSMUSG00000027104


Mus musculus

Features
Gene ID: ENSMUSG00000027104
  
Biological name :Atf2
  
Synonyms : Atf2 / Cyclic AMP-dependent transcription factor ATF-2 / P16951
  
Possible biological names infered from orthology : activating transcription factor 2 / P15336
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 73816509
Gene end: 73892639
  
Corresponding Affymetrix probe sets: 10483737 (MoGene1.0st)   1426582_at (Mouse Genome 430 2.0 Array)   1426583_at (Mouse Genome 430 2.0 Array)   1427559_a_at (Mouse Genome 430 2.0 Array)   1437777_at (Mouse Genome 430 2.0 Array)   1452116_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118560
Ensembl peptide - ENSMUSP00000118357
Ensembl peptide - ENSMUSP00000118719
Ensembl peptide - ENSMUSP00000133632
Ensembl peptide - ENSMUSP00000058521
Ensembl peptide - ENSMUSP00000088311
Ensembl peptide - ENSMUSP00000097588
Ensembl peptide - ENSMUSP00000107638
Ensembl peptide - ENSMUSP00000107641
Ensembl peptide - ENSMUSP00000107647
Ensembl peptide - ENSMUSP00000107648
Ensembl peptide - ENSMUSP00000114828
NCBI entrez gene - 11909     See in Manteia.
MGI - MGI:109349
RefSeq - NM_001284369
RefSeq - NM_001025093
RefSeq - NM_001284370
RefSeq - NM_001284371
RefSeq - NM_001284372
RefSeq - NM_001284373
RefSeq - NM_001284374
RefSeq - NM_001284376
RefSeq - NM_009715
RefSeq Peptide - NP_001271303
RefSeq Peptide - NP_033845
RefSeq Peptide - NP_001020264
RefSeq Peptide - NP_001271298
RefSeq Peptide - NP_001271299
RefSeq Peptide - NP_001271300
RefSeq Peptide - NP_001271301
RefSeq Peptide - NP_001271302
RefSeq Peptide - NP_001271305
swissprot - A2AQF1
swissprot - P16951
swissprot - Q543G2
swissprot - Q640L6
swissprot - F6Z2B2
swissprot - G3UXC3
swissprot - A2AQF0
swissprot - A2AQE9
Ensembl - ENSMUSG00000027104
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf2ENSDARG00000023903Danio rerio
 ATF2ENSGALG00000009287Gallus gallus
 ATF2ENSG00000115966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atf7 / Q8R0S1 / Cyclic AMP-dependent transcription factor ATF-7 / P17544* / AC023509.3* / activating transcription factor 7*ENSMUSG0000009908357
Gm28047 / ATF7* / P17544* / AC023509.3* / activating transcription factor 7*ENSMUSG0000005241450
Creb5 / cAMP responsive element binding protein 5 / Q02930*ENSMUSG0000005300744


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR013087  Zinc finger C2H2-type
 IPR016378  Transcription factor cyclic AMP-dependent, CRE-BP1-type
 IPR029836  cAMP-dependent transcription factor ATF-2
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006970 response to osmotic stress ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0009414 response to water deprivation IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0031573 intra-S DNA damage checkpoint ISO
 biological_processGO:0032915 positive regulation of transforming growth factor beta2 production IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045444 fat cell differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0060612 adipose tissue development IGI
 biological_processGO:0097186 amelogenesis IEA
 biological_processGO:0110024 positive regulation of cardiac muscle myoblast proliferation ISO
 biological_processGO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0035861 site of double-strand break IMP
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding ISO
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0004402 histone acetyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008140 cAMP response element binding protein binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0035497 cAMP response element binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones
Activation of the AP-1 family of transcription factors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * NIH/OlaHsd

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * NIH/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

 MP:0001272 increased metastatic potential 
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Allelic Composition: Ptstm1Ich/Ptstm1Ich,Tg(DBH-PTS)6Csic/0
Genetic Background: B6.Cg-Ptstm1Ich Tg(DBH-PTS)6Csic

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm1Sis/Atf2tm1Sis
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Atf2tm1Sis/Atf2tm1Sis
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atf2tm1Glm/Atf2tm1Sis
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * NIH/OlaHsd

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * NIH/OlaHsd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0003144 reduced number of otoliths "decreased average number of the crystalline calciferous particles adhering to the otolithic membrane" [J:30611, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Atf2tm1Sis/Atf2tm1Sis
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0003410 abnormal artery development "anomaly in the process of forming the blood vessels that carry blood away from the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich,Tg(DBH-PTS)6Csic/0
Genetic Background: B6.Cg-Ptstm1Ich Tg(DBH-PTS)6Csic

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004328 decreased vestibular hair cell number "decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0004330 abnormal saccular macula morphology "any structural abnormalities in the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0004333 abnormal utricular macula morphology "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0004517 decreased vestibular hair cell stereocilia number "decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atf2tm1Sis/Atf2tm1Sis
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich,Tg(DBH-PTS)6Csic/0
Genetic Background: B6.Cg-Ptstm1Ich Tg(DBH-PTS)6Csic

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich,Tg(DBH-PTS)6Csic/0
Genetic Background: B6.Cg-Ptstm1Ich Tg(DBH-PTS)6Csic

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich,Tg(DBH-PTS)6Csic/0
Genetic Background: B6.Cg-Ptstm1Ich Tg(DBH-PTS)6Csic

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich,Tg(DBH-PTS)6Csic/0
Genetic Background: B6.Cg-Ptstm1Ich Tg(DBH-PTS)6Csic

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm1Sis/Atf2tm1Sis
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Atf2tm1Glm/Atf2tm1Sis
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction
 ENSMUSG00000020366 Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*  / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000105827 Q64525 / Hist2h2bb / Histone H2B type 2-B / Q5QNW6* / HIST2H2BF* / histone cluster 2 H2B family member f*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction
 ENSMUSG00000052684 Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*  / reaction / complex






 

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