ENSMUSG00000053007


Mus musculus

Features
Gene ID: ENSMUSG00000053007
  
Biological name :Creb5
  
Synonyms : cAMP responsive element binding protein 5 / Creb5
  
Possible biological names infered from orthology : Q02930
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 53287270
Gene end: 53700376
  
Corresponding Affymetrix probe sets: 10538338 (MoGene1.0st)   10538352 (MoGene1.0st)   1440089_at (Mouse Genome 430 2.0 Array)   1440527_at (Mouse Genome 430 2.0 Array)   1442576_at (Mouse Genome 430 2.0 Array)   1446380_at (Mouse Genome 430 2.0 Array)   1457222_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038532
Ensembl peptide - ENSMUSP00000144979
Ensembl peptide - ENSMUSP00000144925
Ensembl peptide - ENSMUSP00000144851
Ensembl peptide - ENSMUSP00000144719
NCBI entrez gene - 231991     See in Manteia.
MGI - MGI:2443973
RefSeq - XM_017321523
RefSeq - NM_001327821
RefSeq - NM_172728
RefSeq - XM_017321521
RefSeq - XM_017321522
RefSeq Peptide - NP_001314750
RefSeq Peptide - NP_766316
swissprot - A0A0N4SV71
swissprot - A0A0N4SUW5
swissprot - A0A0N4SUK5
swissprot - A0A0N4SV26
Ensembl - ENSMUSG00000053007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 creb5bENSDARG00000070536Danio rerio
 CREB5ENSGALG00000038265Gallus gallus
 CREB5ENSG00000146592Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atf7 / Q8R0S1 / Cyclic AMP-dependent transcription factor ATF-7 / P17544* / AC023509.3* / activating transcription factor 7*ENSMUSG0000009908343
Atf2 / P16951 / Cyclic AMP-dependent transcription factor ATF-2 / P15336* / activating transcription factor 2*ENSMUSG0000002710443
Gm28047 / ATF7* / P17544* / AC023509.3* / activating transcription factor 7*ENSMUSG0000005241439


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR013087  Zinc finger C2H2-type
 IPR016378  Transcription factor cyclic AMP-dependent, CRE-BP1-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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