ENSMUSG00000099083


Mus musculus

Features
Gene ID: ENSMUSG00000099083
  
Biological name :Atf7
  
Synonyms : Atf7 / Cyclic AMP-dependent transcription factor ATF-7 / Q8R0S1
  
Possible biological names infered from orthology : AC023509.3 / activating transcription factor 7 / P17544
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F3
Gene start: 102525946
Gene end: 102625464
  
Corresponding Affymetrix probe sets: 10433032 (MoGene1.0st)   10433034 (MoGene1.0st)   1425653_at (Mouse Genome 430 2.0 Array)   1437645_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093857
Ensembl peptide - ENSMUSP00000139367
Ensembl peptide - ENSMUSP00000139379
Ensembl peptide - ENSMUSP00000104456
Ensembl peptide - ENSMUSP00000130130
Ensembl peptide - ENSMUSP00000139054
Ensembl peptide - ENSMUSP00000139181
Ensembl peptide - ENSMUSP00000139217
Ensembl peptide - ENSMUSP00000139243
Ensembl peptide - ENSMUSP00000139308
NCBI entrez gene - 223922     See in Manteia.
MGI - MGI:2443472
RefSeq - NM_001310067
RefSeq - NM_001310066
RefSeq - NM_001310070
RefSeq Peptide - NP_001296995
RefSeq Peptide - NP_001296996
RefSeq Peptide - NP_001296999
swissprot - Q3TZR9
swissprot - Q3U2X8
swissprot - Q7TNN1
swissprot - Q8R0S1
swissprot - V9GX99
swissprot - V9GXN6
swissprot - V9GXX5
swissprot - V9GXY2
Ensembl - ENSMUSG00000099083
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf7aENSDARG00000011298Danio rerio
 atf7bENSDARG00000055481Danio rerio
 ENSGALG00000039134Gallus gallus
 AC023509.3ENSG00000267281Homo sapiens
 ATF7ENSG00000170653Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm28047 / ATF7* / P17544* / AC023509.3* / activating transcription factor 7*ENSMUSG0000005241485
Atf2 / P16951 / Cyclic AMP-dependent transcription factor ATF-2 / P15336* / activating transcription factor 2*ENSMUSG0000002710457
Creb5 / cAMP responsive element binding protein 5 / Q02930*ENSMUSG0000005300745


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR013087  Zinc finger C2H2-type
 IPR016378  Transcription factor cyclic AMP-dependent, CRE-BP1-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0034399 nuclear periphery ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj
Genetic Background: B6.129P2-Atf2tm2Nicj

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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