ENSMUSG00000053436


Mus musculus

Features
Gene ID: ENSMUSG00000053436
  
Biological name :Mapk14
  
Synonyms : Mapk14 / Mitogen-activated protein kinase 14 / P47811
  
Possible biological names infered from orthology : Q16539
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 28691342
Gene end: 28748404
  
Corresponding Affymetrix probe sets: 10443391 (MoGene1.0st)   1416703_at (Mouse Genome 430 2.0 Array)   1416704_at (Mouse Genome 430 2.0 Array)   1426104_at (Mouse Genome 430 2.0 Array)   1442364_at (Mouse Genome 430 2.0 Array)   1451927_a_at (Mouse Genome 430 2.0 Array)   1459617_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110406
Ensembl peptide - ENSMUSP00000110402
Ensembl peptide - ENSMUSP00000116914
Ensembl peptide - ENSMUSP00000004990
Ensembl peptide - ENSMUSP00000061958
Ensembl peptide - ENSMUSP00000110400
NCBI entrez gene - 26416     See in Manteia.
MGI - MGI:1346865
RefSeq - XM_017317480
RefSeq - NM_001168508
RefSeq - NM_001168513
RefSeq - NM_001168514
RefSeq - NM_011951
RefSeq Peptide - NP_001161980
RefSeq Peptide - NP_036081
RefSeq Peptide - NP_001161985
RefSeq Peptide - NP_001161986
swissprot - Q5U421
swissprot - B2KF35
swissprot - P47811
swissprot - B2KF34
Ensembl - ENSMUSG00000053436
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk14bENSDARG00000028721Danio rerio
 Q9DGE2ENSDARG00000000857Danio rerio
 MAPK14ENSGALG00000042833Gallus gallus
 MAPK14ENSG00000112062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*ENSMUSG0000005313773
Mapk13 / Q9Z1B7 / Mitogen-activated protein kinase 13 / O15264*ENSMUSG0000000486461
Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*ENSMUSG0000002261061
Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*ENSMUSG0000002036649
Mapk10 / mitogen-activated protein kinase 10 isoform 1x / P53779* / mitogen-activated protein kinase 10*ENSMUSG0000004670948
Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*ENSMUSG0000002193648


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IMP
 biological_processGO:0000902 cell morphogenesis IGI
 biological_processGO:0001502 cartilage condensation IMP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IMP
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IGI
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IMP
 biological_processGO:0010831 positive regulation of myotube differentiation IMP
 biological_processGO:0014835 myoblast differentiation involved in skeletal muscle regeneration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0019395 fatty acid oxidation IMP
 biological_processGO:0030278 regulation of ossification IDA
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0031281 positive regulation of cyclase activity ISO
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032495 response to muramyl dipeptide IDA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISO
 biological_processGO:0035994 response to muscle stretch IMP
 biological_processGO:0038066 p38MAPK cascade IMP
 biological_processGO:0042307 positive regulation of protein import into nucleus IMP
 biological_processGO:0042770 signal transduction in response to DNA damage ISO
 biological_processGO:0045648 positive regulation of erythrocyte differentiation ISO
 biological_processGO:0045663 positive regulation of myoblast differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0051146 striated muscle cell differentiation IGI
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IGI
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071223 cellular response to lipoteichoic acid ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071479 cellular response to ionizing radiation ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IMP
 biological_processGO:0090400 stress-induced premature senescence ISO
 biological_processGO:0098586 cellular response to virus ISO
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response ISO
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 biological_processGO:1905050 positive regulation of metallopeptidase activity IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process ISO
 biological_processGO:2001184 positive regulation of interleukin-12 secretion ISO
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding ISO
 molecular_functionGO:0051525 NFAT protein binding IPI


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
Show

Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1.1Dvb/Mapk14+,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oprk1tm1Jep/Oprk1tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
Show

Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk10tm1Flv/Mapk10tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: B6.129S-Mapk9tm1Flv Mapk10tm1Flv

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mapk14tm1Mms/Mapk14tm1Mms
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr
Genetic Background: Not Specified

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1Mms/Mapk14tm1Mms
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax7tm1.1Thbr/Pax7tm1.1Thbr,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr
Genetic Background: Not Specified

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

 MP:0006372 impaired placental function "reduction in the ability of the placenta to supply nutrients or remove waste" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mapk14tm1Mms/Mapk14tm1Mms
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk11tm1Okee/Mapk11tm1Okee
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mapk14tm1Mms/Mapk14tm1Mms
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr
Genetic Background: Not Specified

 MP:0011808 abnormal myoblast differentiation "anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myoblast, a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [GO:0045445]
Show

Allelic Composition: Pax7tm1.1Thbr/Pax7tm1.1Thbr,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Mapk14tm1Mms/Mapk14tm1Mms
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex
 ENSMUSG00000033022 Cdo1 / P60334 / Cysteine dioxygenase type 1 / Q16878*  / complex / reaction
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction
 ENSMUSG00000021180 Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*  / reaction
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / complex
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000030557 Mef2a / Q60929 / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078* / myocyte enhancer factor 2A*  / reaction / complex
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000027104 Atf2 / P16951 / Cyclic AMP-dependent transcription factor ATF-2 / P15336* / activating transcription factor 2*  / reaction
 ENSMUSG00000020167 Tcf3 / P15806 / Transcription factor E2-alpha / P15923* / transcription factor 3*  / reaction
 ENSMUSG00000007670 Khsrp / Q3U0V1 / KH-type splicing regulatory protein / Q92945*  / reaction
 ENSMUSG00000016528 P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*  / complex / reaction
 ENSMUSG00000005583 Mef2c / Q8CFN5 / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413* / myocyte enhancer factor 2C*  / reaction / complex
 ENSMUSG00000020859 Spag9 / Q58A65 / sperm associated antigen 9 / O60271*  / complex / reaction
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex
 ENSMUSG00000032577 Q3UMW7 / Mapkapk3 / MAP kinase-activated protein kinase 3 / Q16644* / mitogen-activated protein kinase-activated protein kinase 3*  / reaction / complex
 ENSMUSG00000029167 O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*  / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / complex
 ENSMUSG00000056220 P47713 / Pla2g4a / phospholipase A2, group IVA (cytosolic, calcium-dependent) / P47712* / phospholipase A2 group IVA*  / reaction
 ENSMUSG00000018932 Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*  / reaction
 ENSMUSG00000020623 Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr