ENSMUSG00000029167


Mus musculus

Features
Gene ID: ENSMUSG00000029167
  
Biological name :Ppargc1a
  
Synonyms : O70343 / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Ppargc1a
  
Possible biological names infered from orthology : PPARG coactivator 1 alpha / Q9UBK2
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C1
Gene start: 51454250
Gene end: 51567726
  
Corresponding Affymetrix probe sets: 10529977 (MoGene1.0st)   10529979 (MoGene1.0st)   1434099_at (Mouse Genome 430 2.0 Array)   1434100_x_at (Mouse Genome 430 2.0 Array)   1437751_at (Mouse Genome 430 2.0 Array)   1456395_at (Mouse Genome 430 2.0 Array)   1460336_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115586
Ensembl peptide - ENSMUSP00000117040
Ensembl peptide - ENSMUSP00000138397
Ensembl peptide - ENSMUSP00000143553
Ensembl peptide - ENSMUSP00000116566
NCBI entrez gene - 19017     See in Manteia.
MGI - MGI:1342774
RefSeq - XM_017320718
RefSeq - XM_006503776
RefSeq - XM_006503777
RefSeq - XM_006503778
RefSeq - XM_017320716
RefSeq - XM_017320717
RefSeq - NM_008904
RefSeq - XM_006503774
RefSeq - XM_006503775
RefSeq Peptide - NP_032930
swissprot - D3YZS8
swissprot - A0A0G2JGG3
swissprot - O70343
swissprot - Q3LIG2
Ensembl - ENSMUSG00000029167
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppargc1aENSDARG00000067829Danio rerio
 PPARGC1AENSGALG00000042851Gallus gallus
 Q9UBK2ENSG00000109819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pprc1 / Q6NZN1 / Mus musculus peroxisome proliferative activated receptor, gamma, coactivator-related 1 (Pprc1), transcript variant 2, mRNA. / Q5VV67* / peroxisome proliferator-activated re...ENSMUSG0000005549130
Q8VHJ7 / Ppargc1b / Peroxisome proliferator-activated receptor gamma coactivator 1-beta / Q86YN6* / PPARG coactivator 1 beta*ENSMUSG0000003387129


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034605  PGC-1
 IPR034625  Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
 IPR034833  PGC-1alpha, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0000422 autophagy of mitochondrion IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002021 response to dietary excess IDA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006012 galactose metabolic process IEA
 biological_processGO:0006094 gluconeogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009750 response to fructose IEA
 biological_processGO:0010822 positive regulation of mitochondrion organization IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014732 skeletal muscle atrophy IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0014850 response to muscle activity IMP
 biological_processGO:0014878 response to electrical stimulus involved in regulation of muscle adaptation IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0022904 respiratory electron transport chain IDA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031325 positive regulation of cellular metabolic process IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0035865 cellular response to potassium ion IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0042752 regulation of circadian rhythm IDA
 biological_processGO:0043201 response to leucine IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045820 negative regulation of glycolytic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046321 positive regulation of fatty acid oxidation IBA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051552 flavone metabolic process IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071250 cellular response to nitrite IEA
 biological_processGO:0071313 cellular response to caffeine IEA
 biological_processGO:0071332 cellular response to fructose stimulus IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071871 response to epinephrine IEA
 biological_processGO:0071873 response to norepinephrine IEA
 biological_processGO:0090258 negative regulation of mitochondrial fission IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:1901215 negative regulation of neuron death ISS
 biological_processGO:1901558 response to metformin IEA
 biological_processGO:1901857 positive regulation of cellular respiration IMP
 biological_processGO:1901860 positive regulation of mitochondrial DNA metabolic process IMP
 biological_processGO:1901863 positive regulation of muscle tissue development IMP
 biological_processGO:1904635 positive regulation of glomerular visceral epithelial cell apoptotic process IEA
 biological_processGO:1904637 cellular response to ionomycin IEA
 biological_processGO:1904639 cellular response to resveratrol IEA
 biological_processGO:1904640 response to methionine IEA
 biological_processGO:1990845 adaptive thermogenesis IEA
 biological_processGO:2000184 positive regulation of progesterone biosynthetic process IEA
 biological_processGO:2000272 negative regulation of signaling receptor activity IEA
 biological_processGO:2000310 regulation of NMDA receptor activity IEA
 biological_processGO:2001171 positive regulation of ATP biosynthetic process IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0022626 cytosolic ribosome IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0097440 apical dendrite IEA
 cellular_componentGO:1990843 subsarcolemmal mitochondrion IEA
 cellular_componentGO:1990844 interfibrillar mitochondrion IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016922 nuclear receptor binding ISO
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IBA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Tg(Vil1-PPARGC1A)#Amos/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atrxtm1Rjg/Y,Tg(Nes-cre)2472Pick/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Atrxtm1Rjg/Y,Tg(Nes-cre)2472Pick/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Atrxtm1Rjg/Y,Tg(Nes-cre)2472Pick/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atrxtm1Rjg/Y,Tg(Nes-cre)2472Pick/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Aggf1tm1Qkw/Aggf1tm1Qkw
Genetic Background: involves: 129 * C57BL/6

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Atrxtm1Rjg/Y,Tg(Nes-cre)2472Pick/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1.1Javi/Ppargc1atm1.1Javi,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Ppargc1atm1.1Javi Tg(Fabp4-cre)1Rev

Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

Allelic Composition: Ppargc1atm1Aztc/Ppargc1atm1Aztc
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atrxtm1Rjg/Y,Tg(Nes-cre)2472Pick/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zap70m1Saka/Zap70tm1Dlo,Tg(Lck-ZAP70)824Saka/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Arntltm2Bra/Arntltm2Bra,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA * ICR

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atrxtm1Rjg/Y,Tg(Nes-cre)2472Pick/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

Allelic Composition: Ppargc1atm1Aztc/Ppargc1atm1Aztc
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargc1atm2Brsp/Ppargc1a+,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Htttm1Mfc/Htt+,Ppargc1atm1Dpk/Ppargc1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1Dpk/Ppargc1btm1Dpk,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1.1Javi/Ppargc1atm1.1Javi,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Ppargc1atm1.1Javi Tg(Fabp4-cre)1Rev

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Tg(Vil1-PPARGC1A)#Amos/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003916 decreased left ventricle weight "less than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

Allelic Composition: Ppargc1atm1Aztc/Ppargc1atm1Aztc
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Htttm1Mfc/Htt+,Ppargc1atm1Dpk/Ppargc1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm1Brsp
Genetic Background: involves: 129 * FVB/N

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Tg(Vil1-PPARGC1A)#Amos/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargc1atm2Brsp/Ppargc1a+,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Atrxtm1Rjg/Y,Tg(Nes-cre)2472Pick/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Ppargc1atm2Brsp/Ppargc1a+,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa13tm1Ipc/Hoxa13+,Hoxd13spdh/Hoxd13+
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Ppargc1atm2Brsp/Ppargc1a+,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

Allelic Composition: Ppargc1atm1Aztc/Ppargc1atm1Aztc
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargc1atm2Brsp/Ppargc1a+,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
Genetic Background: involves: C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm1Brsp
Genetic Background: involves: 129 * FVB/N

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Tg(Vil1-PPARGC1A)#Amos/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Ppargc1atm2Brsp/Ppargc1a+,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm1Brsp
Genetic Background: involves: 129 * FVB/N

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
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Allelic Composition: Ppargc1atm1.1Javi/Ppargc1atm1.1Javi,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Ppargc1atm1.1Javi Tg(Fabp4-cre)1Rev

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1.1Javi/Ppargc1atm1.1Javi,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Ppargc1atm1.1Javi Tg(Fabp4-cre)1Rev

 MP:0009136 decreased brown fat cell size "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Ppargc1atm1.1Javi/Ppargc1atm1.1Javi,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Ppargc1atm1.1Javi Tg(Fabp4-cre)1Rev

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0009422 decreased gastrocnemius weight "reduction in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009426 decreased soleus weight "reduction in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009710 anhedonia "inability to experience pleasure in response to normally pleasurable stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1.1Javi/Ppargc1atm1.1Javi,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Ppargc1atm1.1Javi Tg(Fabp4-cre)1Rev

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1Dpk/Ppargc1btm1Dpk,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1Dpk/Ppargc1btm1Dpk,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk,Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
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Allelic Composition: Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
Genetic Background: involves: C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ppargc1atm1Brsp/Ppargc1atm2Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0013307 increased adrenal gland weight "greater average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla " [MGI:Anna]
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1a+
Genetic Background: C57BL/6-Ppargc1atm1Aztc

 MP:0013894 abnormal behavioral response to amphetamine "anomaly in the behavioral response induced by amphetamine such as induced hyperactivity or stereotypic behavior" [MGI:smb]
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Allelic Composition: Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
Genetic Background: involves: C57BL/6

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Ppargc1atm1Aztc/Ppargc1atm1Aztc
Genetic Background: C57BL/6-Ppargc1atm1Aztc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004864 Mapk13 / Q9Z1B7 / Mitogen-activated protein kinase 13 / O15264*  / reaction
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000024955 Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000032238 Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*  / reaction / complex
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000022610 Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*  / reaction
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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