ENSMUSG00000053137


Mus musculus

Features
Gene ID: ENSMUSG00000053137
  
Biological name :Mapk11
  
Synonyms : Mapk11 / Mitogen-activated protein kinase 11 / Q9WUI1
  
Possible biological names infered from orthology : Q15759
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 89142486
Gene end: 89149628
  
Corresponding Affymetrix probe sets: 10431410 (MoGene1.0st)   1421925_at (Mouse Genome 430 2.0 Array)   1421926_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086204
NCBI entrez gene - 19094     See in Manteia.
MGI - MGI:1338024
RefSeq - NM_011161
RefSeq Peptide - NP_035291
swissprot - Q9WUI1
Ensembl - ENSMUSG00000053137
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk11ENSDARG00000045836Danio rerio
 MAPK11ENSGALG00000040023Gallus gallus
 MAPK11ENSG00000185386Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*ENSMUSG0000005343672
Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*ENSMUSG0000002261062
Mapk13 / Q9Z1B7 / Mitogen-activated protein kinase 13 / O15264*ENSMUSG0000000486458
Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*ENSMUSG0000002036649
Mapk10 / mitogen-activated protein kinase 10 isoform 1x / P53779* / mitogen-activated protein kinase 10*ENSMUSG0000004670949
Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*ENSMUSG0000002193648


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IGI
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:2001184 positive regulation of interleukin-12 secretion IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Bmc/Notch2tm1Bmc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mapk11tm1Okee/Mapk11tm1Okee
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Notch2tm1Bmc/Notch2tm1Bmc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca
Genetic Background: involves: 129P2/OlaHsd

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Bmc/Notch2tm1Bmc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Mapk11tm1Jda/Mapk11tm1Jda,Mapk14tm1Jda/Mapk14tm1Jda
Genetic Background: involves: 129 * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018932 Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*  / reaction
 ENSMUSG00000020623 Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction
 ENSMUSG00000020859 Spag9 / Q58A65 / sperm associated antigen 9 / O60271*  / complex / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / complex
 ENSMUSG00000033022 Cdo1 / P60334 / Cysteine dioxygenase type 1 / Q16878*  / complex / reaction
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction
 ENSMUSG00000030557 Mef2a / Q60929 / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078* / myocyte enhancer factor 2A*  / complex / reaction
 ENSMUSG00000020167 Tcf3 / P15806 / Transcription factor E2-alpha / P15923* / transcription factor 3*  / reaction
 ENSMUSG00000007670 Khsrp / Q3U0V1 / KH-type splicing regulatory protein / Q92945*  / reaction
 ENSMUSG00000027104 Atf2 / P16951 / Cyclic AMP-dependent transcription factor ATF-2 / P15336* / activating transcription factor 2*  / reaction
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000005583 Mef2c / Q8CFN5 / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413* / myocyte enhancer factor 2C*  / complex / reaction
 ENSMUSG00000016528 P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*  / reaction / complex
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / complex
 ENSMUSG00000021180 Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*  / reaction
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction
 ENSMUSG00000032577 Q3UMW7 / Mapkapk3 / MAP kinase-activated protein kinase 3 / Q16644* / mitogen-activated protein kinase-activated protein kinase 3*  / complex / reaction
 ENSMUSG00000029167 O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*  / reaction






 

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