ENSMUSG00000020859


Mus musculus

Features
Gene ID: ENSMUSG00000020859
  
Biological name :Spag9
  
Synonyms : Q58A65 / Spag9 / sperm associated antigen 9
  
Possible biological names infered from orthology : O60271
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 93996091
Gene end: 94126085
  
Corresponding Affymetrix probe sets: 10380341 (MoGene1.0st)   1430556_at (Mouse Genome 430 2.0 Array)   1433648_at (Mouse Genome 430 2.0 Array)   1437676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117502
Ensembl peptide - ENSMUSP00000115864
Ensembl peptide - ENSMUSP00000118850
Ensembl peptide - ENSMUSP00000024979
Ensembl peptide - ENSMUSP00000042271
Ensembl peptide - ENSMUSP00000075115
Ensembl peptide - ENSMUSP00000090452
Ensembl peptide - ENSMUSP00000099457
NCBI entrez gene - 70834     See in Manteia.
MGI - MGI:1918084
RefSeq - XM_006534214
RefSeq - NM_027569
RefSeq - XM_006534210
RefSeq - XM_006534211
RefSeq - XM_006534212
RefSeq - XM_006534213
RefSeq - XM_006534215
RefSeq - XM_006534216
RefSeq - XM_006534217
RefSeq - XM_006534218
RefSeq - XM_006534219
RefSeq - XM_017314758
RefSeq - XM_017314759
RefSeq - XM_017314760
RefSeq - XM_017314761
RefSeq - NM_001025428
RefSeq - NM_001025429
RefSeq - NM_001025430
RefSeq - NM_001199203
RefSeq - NM_001199204
RefSeq - NM_001199205
RefSeq Peptide - NP_001020601
RefSeq Peptide - NP_001186132
RefSeq Peptide - NP_001186133
RefSeq Peptide - NP_001186134
RefSeq Peptide - NP_081845
RefSeq Peptide - NP_001020599
RefSeq Peptide - NP_001020600
swissprot - F6SH61
swissprot - F6WNT4
swissprot - F8WH31
swissprot - E9PUD1
swissprot - Q58A65
swissprot - A0A0R4J196
swissprot - Z4YMB8
Ensembl - ENSMUSG00000020859
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPAG9 (1 of many)ENSDARG00000078142Danio rerio
 spag9aENSDARG00000074531Danio rerio
 SPAG9ENSGALG00000034001Gallus gallus
 SPAG9ENSG00000008294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ESN9 / Mapk8ip3 / C-Jun-amino-terminal kinase-interacting protein 3 / Q9UPT6* / mitogen-activated protein kinase 8 interacting protein 3*ENSMUSG0000002416360
Q80U35 / Arhgef17 / Rho guanine nucleotide exchange factor 17 / Q96PE2*ENSMUSG0000003287524
A2AWP8 / Arhgef10l / Rho guanine nucleotide exchange factor 10-like protein / Q9HCE6* / Rho guanine nucleotide exchange factor 10 like*ENSMUSG0000004096415
Q8C033 / Arhgef10 / Rho guanine nucleotide exchange factor 10 / O15013*ENSMUSG0000007117615


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR019143  JNK/Rab-associated protein-1, N-terminal
 IPR027267  AH/BAR domain superfamily
 IPR032486  JNK-interacting protein, leucine zipper II
 IPR034743  RH1 domain
 IPR034744  RH2 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0016192 vesicle-mediated transport IBA
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISO
 biological_processGO:0043410 positive regulation of MAPK cascade IGI
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0051146 striated muscle cell differentiation IGI
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0090074 negative regulation of protein homodimerization activity IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005078 MAP-kinase scaffold activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008432 JUN kinase binding IDA
 molecular_functionGO:0019894 kinesin binding IDA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IBA
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IDA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtpbp1m2Btlr/Agtpbp1m2Btlr
Genetic Background: C57BL/6J-Agtpbp1m2Btlr

 MP:0001189 absent skin pigmentation "lack of pigmentation of the skin" [J:53370]
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Allelic Composition: Agtpbp1m2Btlr/Agtpbp1m2Btlr
Genetic Background: C57BL/6J-Agtpbp1m2Btlr

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0009280 reduced activated sperm motility "loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtpbp1m2Btlr/Agtpbp1m2Btlr
Genetic Background: C57BL/6J-Agtpbp1m2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / complex / reaction
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / complex
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex
 ENSMUSG00000033022 Cdo1 / P60334 / Cysteine dioxygenase type 1 / Q16878*  / complex / reaction
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / complex / reaction
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / complex
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000022610 Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*  / complex






 

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