ENSMUSG00000022687


Mus musculus

Features
Gene ID: ENSMUSG00000022687
  
Biological name :Boc
  
Synonyms : Boc / BOC cell adhesion associated, oncogene regulated
  
Possible biological names infered from orthology : Q9BWV1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B4
Gene start: 44485049
Gene end: 44558897
  
Corresponding Affymetrix probe sets: 10439612 (MoGene1.0st)   1426869_at (Mouse Genome 430 2.0 Array)   1427516_a_at (Mouse Genome 430 2.0 Array)   1427517_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110281
NCBI entrez gene - 117606     See in Manteia.
MGI - MGI:2151153
RefSeq - NM_172506
RefSeq Peptide - NP_766094
swissprot - D3Z763
Ensembl - ENSMUSG00000022687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bocENSDARG00000074335Danio rerio
 BOCENSGALG00000015152Gallus gallus
 BOCENSG00000144857Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*ENSMUSG0000003811939
Robo1 / roundabout guidance receptor 1 / Q9Y6N7*ENSMUSG0000002288320
Robo2 / roundabout guidance receptor 2 / Q9HCK4*ENSMUSG0000005251618
Robo3 / roundabout guidance receptor 3 / Q96MS0*ENSMUSG0000003212818
Ncam1 / neural cell adhesion molecule 1 isoform 3 / P13591* / neural cell adhesion molecule 1*ENSMUSG0000003954214
Ncam2 / O35136 / Neural cell adhesion molecule 2 / O15394*ENSMUSG0000002276213
Robo4 / roundabout guidance receptor 4 / Q8WZ75*ENSMUSG0000003212511


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR032982  Brother of CDO
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1(MYC/ERT)Hsc/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

Allelic Composition: Boctm2Rsk/Boctm2Rsk
Genetic Background: B6.129S6-Boctm2Rsk

Allelic Composition: Boctm2Rsk/Boctm2Rsk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boctm1Rsk
Genetic Background: involves: 129S6/SvEvTac

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1.2Dunw/Cited2tm1.2Dunw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002235 abnormal external nares morphology "any structural anomaly of the anterior opening to the nasal cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0002239 abnormal nasal septum morphology "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0002820 abnormal premaxilla morphology "malformation or absence of the anterior and inner portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:76662]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0004276 abnormal medial ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0004462 small basisphenoid bone "reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0004463 basisphenoid bone foramen "the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0004538 abnormal maxillary shelf "any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: B6.129-Boctm2Rsk Cdontm1Rsk

Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: B6.129-Boctm1Rsk Cdontm1Rsk

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: B6.129-Boctm2Rsk Cdontm1Rsk

Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: B6.129-Boctm1Rsk Cdontm1Rsk

 MP:0005229 abnormal intervertebral disk development "anomalous fromation of the cartilagenous and gelatinous structure found between vertebrae" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0006197 ocular hypotelorism "the distance between the eyes is reduced" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: B6.129-Boctm2Rsk Cdontm1Rsk

Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: B6.129-Boctm1Rsk Cdontm1Rsk

 MP:0006290 proboscis "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: B6.129-Boctm2Rsk Cdontm1Rsk

Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: B6.129-Boctm1Rsk Cdontm1Rsk

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0009653 abnormal palate development "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0009654 abnormal primary palate development "any anomaly in the formation of the part of the shelf separating the oral and nasal cavities that is formed during early embryonic development from the medial nasal processes which derive from the frontonasal process; these merge with each other and with the bilateral maxillary processes to form the upper lip and the primary palate" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0009897 decreased maxillary shelf size "reduced size of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0012523 abnormal upper lip morphology "any structural anomaly of the muscular fold forming the superior border of the mouth" [MGI:anna]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0013788 external nares atresia "congenital blockage, fusion, or absence of the normal anterior openings to the nasal cavity; the naris may be closed by membrane, cartilage or, rarely, bone" [MGI:Anna]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0030314 absent primary palate "missing the initial portion of the palate formed from the intermaxillary segment" [MGI:anna, UBERON:0005620]
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Allelic Composition: Boctm1Rsk/Boctm1Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm1Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boctm2Rsk,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Boctm2Rsk/Boc+,Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / complex
 ENSMUSG00000021466 Ptch1 / Q61115 / Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA. / Q13635* / patched 1*  / complex
 ENSMUSG00000020859 Spag9 / Q58A65 / sperm associated antigen 9 / O60271*  / complex
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / complex / reaction
 ENSMUSG00000022610 Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*  / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex
 ENSMUSG00000002633 Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*  / complex
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex / reaction
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / reaction / complex
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex / reaction
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / reaction / complex






 

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