ENSMUSG00000002633


Mus musculus

Features
Gene ID: ENSMUSG00000002633
  
Biological name :Shh
  
Synonyms : Q62226 / Shh / Sonic hedgehog protein Sonic hedgehog protein N-product
  
Possible biological names infered from orthology : Q15465 / sonic hedgehog
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 28456815
Gene end: 28467256
  
Corresponding Affymetrix probe sets: 10528872 (MoGene1.0st)   1427571_at (Mouse Genome 430 2.0 Array)   1436869_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002708
NCBI entrez gene - 20423     See in Manteia.
MGI - MGI:98297
RefSeq - NM_009170
RefSeq - XM_006535649
RefSeq Peptide - NP_033196
swissprot - Q62226
Ensembl - ENSMUSG00000002633
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SHHENSGALG00000006379Gallus gallus
 SHHENSG00000164690Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ihh / P97812 / Indian hedgehog / Q14623*ENSMUSG0000000653857
Dhh / Q61488 / Desert hedgehog protein Desert hedgehog protein N-product Desert hedgehog protein C-product / O43323* / desert hedgehog*ENSMUSG0000002300050


Protein motifs (from Interpro)
Interpro ID Name
 IPR000320  Hedgehog, N-terminal signalling domain
 IPR001657  Hedgehog protein
 IPR001767  Hedgehog protein, Hint domain
 IPR003586  Hint domain C-terminal
 IPR003587  Hint domain N-terminal
 IPR006141  Intein N-terminal splicing region
 IPR009045  Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
 IPR036844  Hint domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001570 vasculogenesis IDA
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002052 positive regulation of neuroblast proliferation IDA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0002076 osteoblast development IDA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IMP
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006897 endocytosis IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007228 positive regulation of hh target transcription factor activity IGI
 biological_processGO:0007267 cell-cell signaling IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0007405 neuroblast proliferation IDA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007442 hindgut morphogenesis IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0008209 androgen metabolic process IMP
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009949 polarity specification of anterior/posterior axis IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0010463 mesenchymal cell proliferation IMP
 biological_processGO:0010468 regulation of gene expression ISO
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0014003 oligodendrocyte development IDA
 biological_processGO:0014706 striated muscle tissue development IMP
 biological_processGO:0014858 positive regulation of skeletal muscle cell proliferation IMP
 biological_processGO:0014902 myotube differentiation IMP
 biological_processGO:0016539 intein-mediated protein splicing IEA
 biological_processGO:0021513 spinal cord dorsal/ventral patterning ISO
 biological_processGO:0021521 ventral spinal cord interneuron specification ISO
 biological_processGO:0021522 spinal cord motor neuron differentiation IGI
 biological_processGO:0021794 thalamus development IMP
 biological_processGO:0021871 forebrain regionalization IMP
 biological_processGO:0021904 dorsal/ventral neural tube patterning IMP
 biological_processGO:0021924 cell proliferation in external granule layer IDA
 biological_processGO:0021930 cerebellar granule cell precursor proliferation IGI
 biological_processGO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IMP
 biological_processGO:0021940 positive regulation of cerebellar granule cell precursor proliferation IDA
 biological_processGO:0021978 telencephalon regionalization IMP
 biological_processGO:0030010 establishment of cell polarity IDA
 biological_processGO:0030162 regulation of proteolysis IDA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0030323 respiratory tube development IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0030539 male genitalia development IMP
 biological_processGO:0030850 prostate gland development IMP
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0030900 forebrain development IGI
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IMP
 biological_processGO:0033092 positive regulation of immature T cell proliferation in thymus IMP
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IDA
 biological_processGO:0034504 protein localization to nucleus IDA
 biological_processGO:0035115 embryonic forelimb morphogenesis IMP
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0042307 positive regulation of protein import into nucleus IGI
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0042476 odontogenesis IDA
 biological_processGO:0042481 regulation of odontogenesis IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0045059 positive thymic T cell selection IMP
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0045109 intermediate filament organization IMP
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045445 myoblast differentiation IDA
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IMP
 biological_processGO:0046639 negative regulation of alpha-beta T cell differentiation IMP
 biological_processGO:0048468 cell development IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048557 embryonic digestive tract morphogenesis TAS
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0048617 embryonic foregut morphogenesis IMP
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IMP
 biological_processGO:0048645 animal organ formation IMP
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IMP
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048706 embryonic skeletal system development IGI
 biological_processGO:0048709 oligodendrocyte differentiation IGI
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IDA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0048856 anatomical structure development IMP
 biological_processGO:0048859 formation of anatomical boundary IMP
 biological_processGO:0048864 stem cell development IMP
 biological_processGO:0051146 striated muscle cell differentiation IMP
 biological_processGO:0051155 positive regulation of striated muscle cell differentiation IMP
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IDA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060173 limb development IMP
 biological_processGO:0060174 limb bud formation IMP
 biological_processGO:0060425 lung morphogenesis IMP
 biological_processGO:0060428 lung epithelium development IMP
 biological_processGO:0060438 trachea development IMP
 biological_processGO:0060439 trachea morphogenesis IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IMP
 biological_processGO:0060442 branching involved in prostate gland morphogenesis IDA
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IMP
 biological_processGO:0060447 bud outgrowth involved in lung branching IMP
 biological_processGO:0060458 right lung development IMP
 biological_processGO:0060459 left lung development IMP
 biological_processGO:0060463 lung lobe morphogenesis IMP
 biological_processGO:0060484 lung-associated mesenchyme development IMP
 biological_processGO:0060516 primary prostatic bud elongation IDA
 biological_processGO:0060523 prostate epithelial cord elongation IDA
 biological_processGO:0060662 salivary gland cavitation IDA
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis IMP
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IMP
 biological_processGO:0060685 regulation of prostatic bud formation IMP
 biological_processGO:0060738 epithelial-mesenchymal signaling involved in prostate gland development IEA
 biological_processGO:0060768 regulation of epithelial cell proliferation involved in prostate gland development IMP
 biological_processGO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development IMP
 biological_processGO:0060782 regulation of mesenchymal cell proliferation involved in prostate gland development IMP
 biological_processGO:0060783 mesenchymal smoothened signaling pathway involved in prostate gland development IMP
 biological_processGO:0060840 artery development IMP
 biological_processGO:0060916 mesenchymal cell proliferation involved in lung development IDA
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS
 biological_processGO:0061053 somite development IMP
 biological_processGO:0061189 positive regulation of sclerotome development IEA
 biological_processGO:0071285 cellular response to lithium ion IDA
 biological_processGO:0071542 dopaminergic neuron differentiation TAS
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090370 negative regulation of cholesterol efflux IMP
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:1900180 regulation of protein localization to nucleus IEA
 biological_processGO:1904339 negative regulation of dopaminergic neuron differentiation IMP
 biological_processGO:1905327 tracheoesophageal septum formation IMP
 biological_processGO:2000062 negative regulation of ureter smooth muscle cell differentiation IDA
 biological_processGO:2000063 positive regulation of ureter smooth muscle cell differentiation IMP
 biological_processGO:2000357 negative regulation of kidney smooth muscle cell differentiation IDA
 biological_processGO:2000358 positive regulation of kidney smooth muscle cell differentiation IDA
 biological_processGO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development IMP
 biological_processGO:2001054 negative regulation of mesenchymal cell apoptotic process IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0005113 patched binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005539 glycosaminoglycan binding IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043237 laminin-1 binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog ligand biogenesis
Release of Hh-Np from the secreting cell
Ligand-receptor interactions
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000033 absent cochlear duct "missing spiral tube within the cochlea; contains the neuroepithelial receptor organ for hearing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0000041 absent endolymphatic duct "missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000077 abnormal interparietal bone morphology "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

 MP:0000090 absent premaxilla "missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Disp1tm2Amc/Disp1tm2Amc
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0000094 absent alveolar process "missing projecting ridge on the inferior surface of the body of the maxilla containing the tooth sockets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Disp1tm2Amc/Disp1tm2Amc
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0000118 arrest of tooth development "failure of differentiation of the teeth" [J:18378]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000128 growth retardation of molars "developmental delay of the growth of the molars" [J:17489]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000138 absent vertebrae "missing bony segments of the spinal column" [J:35802]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Zic2Ku/Zic2Ku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sor+,Tg(SFTPC-rtTA)5Jaw/0
Genetic Background: Not Specified

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000388 absent inner root sheath "missing epidermally derived layer surrounding the hair follicle; innermost of two layers" [J:65047]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0000413 polyphalangy "increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/0
Genetic Background: involves: 129S1/Sv

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm2.1Alj/Gli2+,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0000453 absent mouth "missing oral cavity" [J:35802]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0000467 abnormal esophagus morphology "malformation of the part of the digestive canal through which food passes from the pharynx to the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Jag1Yo/Jag1Yo
Genetic Background: C3HeB/FeJ-Jag1Yo

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

Allelic Composition: ShhDsh/ShhDsh
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000551 absent forelimb "missing the entire anterior extremities" [MGI:tc, J:54637]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0000557 absent hindlimb "missing the entire posterior extremities" [MGI:tc, J:54637]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000561 adactyly "missing all digits; usually refered to as a congenital condition" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gli3tm2Blnw/Gli3+,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: ShhM101116/Shh+
Genetic Background: D2;B6-ShhM101116/Rbrc

Allelic Composition: ShhM101116/ShhM101116
Genetic Background: D2;B6-ShhM101116/Rbrc

Allelic Composition: ShhDz/ShhDz
Genetic Background: C57BL/6J-ShhDz

Allelic Composition: ShhDz/Shh+
Genetic Background: C57BL/6J-ShhDz

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hhattm2Ptch/Hhattm2Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Tulp3hhkr/Tulp3hhkr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Tmem107schlei/Tmem107schlei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Gata6tm2.1Sad/Gata6tm2.1Sad,Shhtm2Amc/Shhtm2Amc,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Rr29tm1.1Bobh/Rr29+,Shhtm1Chg/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000566 synostosis "osseous union of two bones that are not normally connected" [J:13049]
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Allelic Composition: Gli3tm2Blnw/Gli3+,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli3tm2Blnw/Gli3+,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0000646 enlarged adrenocortical cells "larger size of cells of the adrenal gland " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000767 abnormal smooth muscle morphology "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Zic2Ku/Zic2Ku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Shhtm1.1Rseg/Shhtm1.1Rseg
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Shhtm1Amc/Shhtm1.1Rseg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Shhtm1.1Rseg/Shhtm1.1Rseg
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Shhtm1Chg/Shhtm1Chg,Tulp3hhkr/Tulp3hhkr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6

Allelic Composition: Ift122sopb/Ift122sopb,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Tmem107schlei/Tmem107schlei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Tmem107schlei/Tmem107schlei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Disp1tm2.1Amc/Disp1tm2.1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Ift122sopb/Ift122sopb,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gli2tm2.1Alj/Gli2+,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm2.1Alj/Gli2+,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0001181 absent lungs "missing organs of respiration" [J:51966, J:50768]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Slc17a8tm1Edw/Slc17a8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Efnb3tm1.1Henk/Efnb3tm1.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Shhtm1Amc/Shhtm1.1Rseg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: C.129S2-Stat4tm1Gru

Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Ndst1tm1.1Grob/Ndst1+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

Allelic Composition: Shhtm1.1Rseg/Shhtm1.1Rseg
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Shhtm1Amc/Shhtm1.1Rseg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: ShhDsh/ShhDsh
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gli2tm2.1Alj/Gli2+,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Zic2Ku/Zic2Ku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: ShhDsh/Shhtm1Chg
Genetic Background: involves: 101 * 129S1/Sv * 129X1/SvJ * C3H * C57BL/10Rl

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Tyrc-32DSD/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Tyrc-32DSD/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Shhtm1Chg/Shhtm1Chg,Tulp3hhkr/Tulp3hhkr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Disp1tm2Amc/Disp1tm2Amc
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Slc17a8tm1Edw/Slc17a8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: C.129S2-Stat4tm1Gru

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: ShhDsh/Shhtm1Chg
Genetic Background: involves: 101 * 129S1/Sv * 129X1/SvJ * C3H * C57BL/10Rl

Allelic Composition: Gli3tm2Blnw/Gli3+,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: ShhDz/ShhDz
Genetic Background: C57BL/6J-ShhDz

Allelic Composition: Rr29tm1.1Bobh/Rr29+,Shhtm1Chg/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gli3tm2Blnw/Gli3+,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Shhtm1Amc/Shhtm2Amc,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1(EGFP/cre)Cjt/Shhtm2Amc
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Tulp3hhkr/Tulp3hhkr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6

Allelic Composition: Ift122sopb/Ift122sopb,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ptch1tm1Mps/Ptch1+,Shhtm6Amc/Shhtm6Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Shhtm1(cre/ERT2)Tshim/Shhtm1(cre/ERT2)Tshim
Genetic Background: Not Specified

Allelic Composition: Shhtm1Ahk/Shhtm1Ahk
Genetic Background: B6.Cg-Shhtm1Ahk

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

Allelic Composition: Shh+/Shhtm1Chg,Zic2Ku/Zic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1.1Rseg/Shhtm1.1Rseg
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Shhtm1Amc/Shhtm1.1Rseg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

Allelic Composition: Shhtm1Chg/Shhtm2Chg,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002234 abnormal pharynx morphology "structural anomaly in the passage between the mouth and the posterior nares and the larynx and esophagus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002257 abnormal arytenoid cartilage morphology "any structural anomaly of the paired triangular cartilages located postlaterally at the level of the thyroid cartilage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002284 abnormal tracheal smooth muscle morphology "structural anomaly of the smooth muscle lining the trachea" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0002285 abnormal tracheal ciliated epithelium morphology "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Chg/Shhtm2Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Shhtm1Chg/Shhtm2Chg,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002726 abnormal pulmonary vein morphology "structrual anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ

 MP:0002728 absent tibia "missing the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gli3tm2Blnw/Gli3+,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Shhtm1.1Rseg/Shhtm1.1Rseg
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Shhtm1Amc/Shhtm1.1Rseg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gli3tm2Blnw/Gli3+,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: ShhDz/ShhDz
Genetic Background: C57BL/6J-ShhDz

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: ShhDz/ShhDz
Genetic Background: C57BL/6J-ShhDz

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002858 abnormal posterior semicircular canal "anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0002898 absent cartilage "absence of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002909 abnormal adrenal gland physiology "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shhtm1Chg/Shhtm2Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0002990 short ureter "reduced length of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Shhtm1Chg/Shhtm1Chg,Tulp3hhkr/Tulp3hhkr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6

 MP:0003069 abnormal superior semicircular canal "anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003115 abnormal respiratory system development "aberrant differentiation of pulmonary tissues" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003130 anal atresia "absence of a connection between the anal pit and the rectum" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0003161 absent lateral semicircular canal 
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003189 fused joints 
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0003283 abnormal digestive organ placement "different location or arrangement of any of the alimentary tract organs" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0003451 absent olfactory bulb "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003626 kidney medulla hypoplasia 
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Disp1tm2.1Amc/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0003793 abnormal submandibular gland morphology "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0003855 abnormal forelimb zeugopod morphology 
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Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003857 abnormal hindlimb zeugopod morphology 
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Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003923 abnormal left atrium morphology "structural anomaly of the left upper chamber of the heart " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004137 abnormal gastric surface mucous cells "malformation of the mucus secreting epithelial cells that lline the luminal surface of the stomach, gastric pits and gastric glands" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004173 abnormal intervertebral disk morphology "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tyrc-32DSD/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Shhtm1Chg/Shhtm1Chg,Zic2Ku/Zic2Ku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

 MP:0004196 abnormal prenatal growth/weight/body size "limited or accelerated growth or development apparent before birth" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004269 abnormal optic cup morphology "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Shhtm1.1Rseg/Shhtm1.1Rseg
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Shhtm1.1Rseg/Shhtm1.1Rseg
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004276 abnormal medial ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004313 absent vestibulocochlear ganglion "absence of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0004315 absent saccule "absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004358 bowed tibia "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ShhDz/ShhDz
Genetic Background: C57BL/6J-ShhDz

 MP:0004369 absent utricle "absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0004372 bowed fibula "increased curvature of the lateral and smaller bone of the lower limb" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ShhDz/ShhDz
Genetic Background: C57BL/6J-ShhDz

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004419 absent parietal bone "absence of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0004423 abnormal squamosal bone morphology "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004442 occipital bone foramen "presence of a hole in the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004473 absent nasal bone "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0004506 abnormal pubic bone morphology "any structural anomaly in the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004507 abnormal ischium morphology "any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004508 abnormal shoulder bone morphology "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004538 abnormal maxillary shelf "any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004551 decreased tracheal cartilage ring number "less than the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0004553 absent tracheal cartilage rings "absence of the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0004576 abnormal foot plate morphology "any structural anomaly of the distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. hand, foot, paw)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0004634 short metacarpal bones "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0004658 abnormal ventral tubercle of atlas "any structural anomaly of the conical ventral projection on the arch of the atlas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0004712 notochord degeneration "retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004872 absent nasal septum "absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004880 lung cysts 
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005084 abnormal gall bladder morphology "anomalous structure or development of the organ which serves as a storage reservoir for bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Shhtm1(EGFP/cre)Cjt/Shh+,Sox17tm1Ysk/Sox17+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1(EGFP/cre)Cjt/Shhtm2Amc
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

 MP:0005213 gastric metaplasia "condition in which there is a change of one adult cell type to another adult cell type in the stomach " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Gli3tm2Blnw/Gli3+,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005359 growth retardation of incisors "developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005430 absent fibula "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: ShhDz/ShhDz
Genetic Background: C57BL/6J-ShhDz

 MP:0005493 stomach epithelial hyperplasia 
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+,Tg(tetO-Vegfa)1Kesh/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0006098 absent cerebellar lobules "missing lobes of the cerebellum" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Chg/Shhtm2Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0006197 ocular hypotelorism "the distance between the eyes is reduced" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006261 annular pancreas "an abnormal ring or collar of pancreatic tissue that encircles the duodenum" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:69854]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0006281 abnormal tail development "anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006290 proboscis "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006306 abnormal nasal pit morphology "malformation of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Disp1tm2.1Amc/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006402 small molars "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008004 abnormal stomach pH "anomaly in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, as measured by the concentration of the hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0008291 abnormal adrenocortical cell morphology "any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0008302 thin adrenal cortex "reduced thickness of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0008985 hemimelia "congenital absence of part of an extremity, such as absent fibula with the tibia present" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ShhDz/ShhDz
Genetic Background: C57BL/6J-ShhDz

 MP:0009204 absent external male genitalia "absence of the external masculine genital organs, including the penis and scrotum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

 MP:0009211 absent external female genitalia "absence of the external feminine genital organs, collectively known as the vulva" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

 MP:0009493 abnormal cystic duct morphology "any structural anomaly of the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009545 abnormal dermis papillary layer "any structural anomaly of the more superficial, thin layer of the dermis that interdigitates with the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0009579 acephaly "congenital absence of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/0
Genetic Background: involves: 129S1/Sv

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/0
Genetic Background: involves: 129S1/Sv

 MP:0009844 abnormal neural crest cell apoptosis "change in the timing or the number of neural crest cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Chg/Shhtm2Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009901 abnormal frontonasal prominence morphology "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Disp1icb/Disp1icb
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0009903 abnormal medial nasal prominence morphology "any structural anomaly of the central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009905 absent tongue "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1tm2.1Amc/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Disp1tm2.1Amc/Disp1tm2.1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0010030 abnormal orbit morphology "any structural anomaly of the bony ring that supports the eyeball and supporting tissues and is formed by parts of several cranial bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0010059 olfactory bulb hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010371 abnormal epiglottis morphology "any structural anomaly of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0010493 abnormal atrium myocardium morphology "any structural anomaly of the atrial part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010646 absent pulmonary vein "absence of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010701 fusion of atlas and odontoid process "the large protuberance that projects upward from the cervical axis (C2), around which the cervical atlas normally rotates, is instead fused to elements of the atlas; the odontoid process may or may not remain attached to the axis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0010784 abnormal forestomach morphology "any structural anomaly of the dilated area of tissue where the stomach and esophagus meet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmpr1a)Que/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/?
Genetic Background: Not Specified

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0010862 decreased respiratory mucosa goblet cell number "reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010883 trachea stenosis "abnormal narrowing or constriction of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010897 abnormal bronchiole epithelium morphology "any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0010907 absent lung buds "absence of the blunt end of the respiratory diverticulum which normally grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the origins of the bronchial tree" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010915 increased solitary pulmonary neuroendocrine cell number "increased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0010940 abnormal maxillary prominence morphology 
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Allelic Composition: Ndst1tm1.1Grob/Ndst1+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010942 abnormal respiratory epithelium morphology "any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0010949 decreased Clara cell number "reduced number of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmem107schlei/Tmem107tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0010976 small lung lobe "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

 MP:0010994 aerophagia "excessive swallowing of air or gas" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011011 impaired lung lobe morphogenesis "failure to form any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011028 impaired branching involved in bronchus morphogenesis 
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: C57BL/6

 MP:0011071 absent Clara cells "absence of the rounded, club-shaped, nonciliated cells found between ciliated cells in the bronchiolar epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Shhtm2Chg/Shhtm2Chg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Disp1icb/Disp1icb
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Jag1Yo/Jag1Yo
Genetic Background: C3HeB/FeJ-Jag1Yo

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmpr1a)Que/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/?
Genetic Background: Not Specified

Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: ShhDsh/ShhDsh
Genetic Background: B10Rl.Cg-ShhDsh

Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: ShhDsh/ShhDsh
Genetic Background: involves: 101 * C3H * C57BL * SEC

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

 MP:0011113 abnormal airway basal cell morphology "any structural anomaly of a long-lived multipotent stem cell of the pseudostratified airway epithelium which is restricted to the tracheal epithelium in mice; airway BCs have been shown to be capable of self renewal, give rise to secretory (Clara) cells and ciliated cells, and play important roles both in epithelial homeostasis and in pathological airway remodeling" [MGI:anna, PMID:20699479]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011142 abnormal lung-associated mesenchyme development "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]
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Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011147 increased mesenchymal cell proliferation involved in lung development "increase in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011333 abnormal kidney inner medulla morphology "any structural anomaly of the inner medullary region of the adult kidney containing collecting ducts and the long loops of Henle" [MGI:csmith, PMID:20614633]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0011360 kidney cortex hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the outer portion of the kidney, which contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts" [MGI:anna]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0011378 abnormal kidney outer medulla inner stripe morphology "any structural anomaly of the deep, centrally located portion of the renal outer medulla that is traversed by thin descending and thick ascending portions of the loops of Henle" [GO:0072057]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011415 abnormal aldosterone level "anomaly in the concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule" [ISBN:0-683-40008-8]
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Allelic Composition: Nr5a1tm1.1Hain/Nr5a1tm1.1Hain,Shhtm1Amc/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011426 abnormal ureter smooth muscle morphology "any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter" [MGI:anna]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0011485 abnormal urethra urothelium morphology "any structural anomaly of the epithelial lining of the luminal space of the urethra" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+,Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0011771 abnormal genital tubercle morphology "any structural anomaly of the embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation" [MGI:anna]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt
Genetic Background: involves: 129S6/SvEvTac

 MP:0011805 decreased cell migration "reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012091 increased midbrain size "greater than average size of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0012139 increased forebrain size "greater than average size of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Tctn1Gt(KST296)Byg/Tctn1Gt(KST296)Byg,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012197 impaired myofibroblast differentiation 
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012257 absent philtrum "absence of the vertical groove normally found on the median line of the upper lip" [MGI:anna]
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Allelic Composition: Six3tm3.1Gco/Six3+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012517 absent diencephalon "absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MGI:anna]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0013790 single external naris "presence of only one anterior opening to the nasal cavity as opposed to the normal two; usually associated with midline facial defects arising from cleavage anomalies" [MGI:Anna]
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Allelic Composition: Gas1tm2Fan/Gas1tm2Fan,Shhtm1Chg/Shh+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0014155 absent olfactory epithelium "absence of the epithelial cells that line the interior of the nose" [MGI:csmith]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014200 abnormal respiratory epithelium physiology "any functional anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [ISBN:0-683-40008-8, MGI:Anna]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020134 abnormal gallbladder size "an anomaly in the size of the gall bladder compared to average, the organ that serves as a storage reservoir for bile" [GOC:NV]
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Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020516 abnormal visceral yolk sac mesenchyme morphology "any structural anomaly of the portion of the visceral yolk sac that is derived from mesoderm and consists of mesenchyme" [UBERON:0003316]
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Allelic Composition: Tyrc-32DSD/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0020530 disorganized thalamus "derangement of the pattern of thalamic tissues" [MGI:smb]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0030002 increased lung apoptosis "acceleration in the timing or in the number of cells of the lung undergoing programmed cell death" [ORCID:orcid.org/0000-0002-6490-7723, PMID:17589521]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0030079 small incisors "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0030136 abnormal lower incisor morphology "any structural anomaly of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0030190 small snout "decreased size of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030250 frontonasal prominence hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1+,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Shhtm1Chg/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030277 thin interparietal bone "reduced thickness of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:anna]
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Allelic Composition: ShhDsh/Shh+
Genetic Background: B10Rl.Cg-ShhDsh

 MP:0030453 abnormal odontoblast morphology "any structural anomaly of the skeletogenic cell on the outer surface of the dental pulp that secretes dentin matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell" [CL:0000060, GO:0071895]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0030527 absent enamel cord "missing the transient structure of the dental (enamel) organ that is normally present at the early cap stage of molar tooth development; the enamel cord is a strand of epithelial cells that runs from (links) the enamel knot to the outer dental epithelial cells, dividing the dental organ into two parts" [https://en.wikipedia.org/wiki/Enamel_cord, ISBN:978-0-12-597951-1, MGI:anna]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000064325 Hhip / Q7TN16 / Hedgehog-interacting protein / Q96QV1*  / complex / reaction
 ENSMUSG00000024807 Syvn1 / synovial apoptosis inhibitor 1, synoviolin / Q86TM6* / synoviolin 1*  / complex / reaction
 ENSMUSG00000040035 2 / Disp2 / Q8CIP5 / A7MBM2* / dispatched RND transporter family member 2*  / complex
 ENSMUSG00000020311 Erlec1 / Q8VEH8 / Endoplasmic reticulum lectin 1 / Q96DZ1*  / reaction / complex
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / complex / reaction
 ENSMUSG00000040462 Os9 / Q8K2C7 / Protein OS-9 / Q13438* / OS9, endoplasmic reticulum lectin*  / complex / reaction
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / reaction / complex
 ENSMUSG00000020964 Sel1l / Q9Z2G6 / sel-1 suppressor of lin-12-like (C. elegans) / Q9UBV2* / SEL1L ERAD E3 ligase adaptor subunit*  / complex / reaction
 ENSMUSG00000022112 Gpc5 / Q8CAL5 / glypican 5 / P78333*  / complex / reaction
 ENSMUSG00000007279 Q9JJS0 / Scube2 / Signal peptide, CUB and EGF-like domain-containing protein 2 / Q9NQ36* / signal peptide, CUB domain and EGF like domain containing 2*  / complex / reaction
 ENSMUSG00000018442 Derl2 / Q8BNI4 / Derlin-2 / Q9GZP9*  / complex / reaction
 ENSMUSG00000052957 Gas1 / Q01721 / Growth arrest-specific protein 1 / P54826* / growth arrest specific 1*  / complex / reaction
 ENSMUSG00000021466 Ptch1 / Q61115 / Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA. / Q13635* / patched 1*  / reaction / complex
 ENSMUSG00000037375 Hhat / Q8BMT9 / Protein-cysteine N-palmitoyltransferase HHAT / Q5VTY9* / hedgehog acyltransferase*  / reaction
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / reaction / complex
 ENSMUSG00000042988 Notum / Q8R116 / Palmitoleoyl-protein carboxylesterase NOTUM / Q6P988* / notum, palmitoleoyl-protein carboxylesterase*  / reaction
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex






 

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