Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000074	abnormal neurocranium morphology	"malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0000077	abnormal interparietal bone morphology	"malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0000106	abnormal basisphenoid bone morphology	"malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0000107	abnormal frontal bone morphology	"malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0000159	abnormal xiphoid process	"malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Brd2^{Gt(RRE050)Byg}/Brd2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy,Ptch1^tm1Yy/Ptch1^tm1.1Yy,Tg(Col2a1-cre)1Bhr/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000259	abnormal vascular development	"malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]	Show Allelic Composition: Cdkn1a^tm1Led/Cdkn1a^tm1Led,Zbtb17^tm1Cksn/Zbtb17^tm1Cksn,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Zbtb17^tm1Cksn Cdkn1a^tm1Led Commd10^{Tg(Vav1-icre)A2Kio}
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Il2rg^tm1Sug/Y Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0000373	belly spot	"the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brd2^{Gt(RRE050)Byg}/Brd2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000418	patchy hair	"uneven spots of hair growth on the body" [J:26975]	Show Allelic Composition: Ccne2^tm1Pisc/Ccne2^tm1Pisc Genetic Background: involves: 129S2/SvPas
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: A^vy/A^vy Genetic Background: involves: C3H/HeJ Allelic Composition: Hhat^{Tg(TFAP2A-cre)1Will}/Hhat⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0000432	abnormal head morphology	"anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tff1^tm1Mrio/Tff1^tm1Mrio Genetic Background: involves: 129S2/SvPas Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Zim Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J Allelic Composition: Disp1^icb/Disp1^icb,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0000435	shortened head	"reduced anterior-posterior length of the head" [J:42035]	Show Allelic Composition: Brd2^{Gt(RRE050)Byg}/Brd2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0000440	domed skull		Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Zim Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J
MP:0000473	abnormal stomach glandular epithelium morphology	"malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: Apoe^tm1Bres/Apoe^tm1Bres,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2^tm1Pmc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0000564	syndactyly	"any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0000574	abnormal foot pad morphology	"anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Zim Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J
MP:0000588	thick tail	"a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0000753	paralysis	"loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^tm1Yy/Ptch1⁺,Trp53^tm1Brd/Trp53⁺,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ
MP:0000830	abnormal diencephalon morphology	"any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: En1^tm2(cre)Gld/En1⁺,Gli2^tm1Alj/Gli2^tm6Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre)1Bfri/0 Genetic Background: involves: 129T2/SvEms * C57BL/6 * CBA
MP:0000854	abnormal cerebellum development	"malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: En1^tm2(cre)Gld/En1⁺,Gli2^tm1Alj/Gli2^tm6Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
MP:0000857	abnormal cerebellar foliation	"malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]	Show Allelic Composition: En1^tm2(cre)Gld/En1⁺,Gli2^tm1Alj/Gli2^tm6Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
MP:0000872	abnormal external granule cell layer	"malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre)1Bfri/0 Genetic Background: involves: 129T2/SvEms * C57BL/6 * CBA Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre/Esr1)14Fsh/0 Genetic Background:* involves: 129T2/SvEms * FVB/N Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(GFAP-cre)25Mes/0 Genetic Background: involves: 129T2/SvEms * FVB/N
MP:0000889	abnormal cerebellar molecular layer	"any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Gli1^tm2Alj/Gli1^tm2Alj,Gli2^tm1Alj/Gli2^tm1Alj Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Hhip^tm1Amc/Hhip⁺,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB Allelic Composition: Gli2^tm1Alj/Gli2^tm1Alj,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ Allelic Composition: Ptch1^tm1Mps/Ptch1^tm1Mps,Tmem107^schlei/Tmem107^schlei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0000928	incomplete cephalic closure	"arrest of the fusion of the cephalic neural folds" [J:12622]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Il2rg^tm1Sug/Y Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ptch1^tm1.1Bjw/Ptch1^tm1.1Bjw Genetic Background: involves: 129T2/SvEms * C57BL/6J Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ Allelic Composition: Ptch1^tm1.1Hahn/Ptch1^tm1.1Hahn Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N Allelic Composition: Disp1^icb/Disp1^icb,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0000934	abnormal telencephalon development	"malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]	Show Allelic Composition: A^vy/A^vy Genetic Background: involves: C3H/HeJ
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli1^tm2Alj/Gli1^tm2Alj,Gli2^tm1Alj/Gli2^tm1Alj Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster
MP:0001081	abnormal cranial ganglia morphology	"any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0001082	abnormal geniculate ganglion morphology	"malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0001092	abnormal trigeminal ganglion morphology	"malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0001096	abnormal glossopharyngeal ganglion morphology	"malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Brd2^{Gt(RRE050)Byg}/Brd2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001157	small seminal gland	"reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129T2/SvEms * FVB/N
MP:0001247	dermal cysts	"abnormal membranous sacs appearing in the dermis" [J:53379]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)
MP:0001264	increased body size	"larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129/Sv * C57BL/6J * MF1 Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0001272	increased metastatic potential		Show Allelic Composition: Ptch1^tm1Yy/Ptch1⁺,Trp53^tm1Brd/Trp53⁺,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
MP:0001300	ocular hypertelorism	"increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0001648	abnormal apoptosis	"excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1^tm1Zim,Stil^tm1Mku/Stil^tm1Mku Genetic Background: involves: 129/Sv
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1^tm1Mps,Wdpcp^cys40/Wdpcp^cys40 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1^tm1Mps,Tmem107^schlei/Tmem107^schlei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0001699	enlarged embryo size	"larger proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: A^vy/A^vy Genetic Background: involves: C3H/HeJ
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129T2/SvEms * FVB/N
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129T2/SvEms * FVB/N
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Il2rg^tm1Sug/Y Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129T2/SvEms * FVB/N
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2^tm1Pmc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ Allelic Composition: Ptch1^tm1.1Hahn/Ptch1⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 Allelic Composition: Ptch1^tm1Hahn/Ptch1⁺,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0002036	rhabdomyosarcoma	"malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Parms1^C57BL/6NCrl/Parms1^C57BL/6NCrl,Ptch1^tm1Zim/Ptch1⁺ Genetic Background: involves: 129/Sv * BALB/cByJ * C57BL/6NCrl Allelic Composition: Parms1^BALB/cByJ/Parms1^C57BL/6NCrl,Ptch1^tm1Zim/Ptch1⁺ Genetic Background: involves: 129/Sv * BALB/cByJ * C57BL/6NCrl Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2^tm1Pmc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 Allelic Composition: Ptch1^tm1.1Hahn/Ptch1⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: A^vy/A^vy Genetic Background: involves: C3H/HeJ Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre)1Bfri/0 Genetic Background: involves: 129T2/SvEms * C57BL/6 * CBA Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre/Esr1)14Fsh/0 Genetic Background:* involves: 129T2/SvEms * FVB/N Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(GFAP-cre)25Mes/0 Genetic Background: involves: 129T2/SvEms * FVB/N Allelic Composition: Ptch1^tm1.1Hahn/Ptch1⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 Allelic Composition: Ptch1^tm1Hahn/Ptch1⁺,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Hahn/Ptch1⁺,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Yy/Ptch1^tm1Yy,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: 129 * C57BL/6 * FVB/NJ
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apc^Min/Apc⁺ Genetic Background: B6(AKR)-Apc^Min
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB Allelic Composition: Hhip^tm1Amc/Hhip⁺,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB Allelic Composition: Kif7^maki/Kif7^maki,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Hlxb9-GFP)1Tmj/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N Allelic Composition: Gli2^tm3.1Blnw/Gli2^tm3.1Blnw,Ptch1^tm1Mps/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6 Allelic Composition: Disp1^icb/Disp1^icb,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: A^vy/A^vy Genetic Background: involves: C3H/HeJ Allelic Composition: Disp1^tm1Amc/Disp1^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Shh^tm6Amc/Shh^tm6Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002271	abnormal alveolar duct morphology	"any structural anomaly of the conducting tubes leading to the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002286	cryptorchism	"failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0002367	abnormal thymus lobule morphology	"anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002396	abnormal hematopoietic system morphology/development	"any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002407	abnormal double-negative T cell	"anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002576	abnormal enamel morphology	"malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp4^tm2Her/Lrp4^tm2Her Genetic Background: involves: 129S/SvEv
MP:0002716	small preputial glands	"reduced size of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator, J:82312]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003052	omphalocele	"protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^dl/Ptch1^tm1Zim Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J
MP:0003054	spina bifida	"common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Hhip^tm1Amc/Hhip⁺,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
MP:0003190	fused synovial joints	"partial or complete absence of separations containing synovial fluid between bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93028]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy,Ptch1^tm1Yy/Ptch1^tm1.1Yy,Tg(Col2a1-cre)1Bhr/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0003345	decreased number of ribs	"fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)
MP:0003414	epidermal cyst	"a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1⁺,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy,Ptch1^tm1Yy/Ptch1^tm1.1Yy,Tg(Col2a1-cre)1Bhr/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0003447	reduced tumor growth/size	"less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]	Show Allelic Composition: Sptb^m1Jus/Sptb^m1Jus Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003460	decreased fear-related response	"reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0003580	fibroma	"a benign tumor of fibrous or fully developed connective tissue " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1⁺,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0003641	small lung	"reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003667	hemangiosarcoma	"a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0003703	abnormal vestibulocochlear ganglion morphology	"malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0003720	abnormal neural tube closure	"abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]	Show Allelic Composition: Irs1^smla/Irs1^smla Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Ptch1^tm1Mps/Ptch1^tm1Mps,Tmem107^schlei/Tmem107^schlei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0003789	osteosarcoma	"malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^tm1Yy/Ptch1⁺,Trp53^tm1Brd/Trp53⁺,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ
MP:0003841	abnormal lambdoidal suture morphology	"malformation of the articulation of the parietal bones and the occipital bone" [Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0003934	abnormal pancreas development	"anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003992	increased mortality induced by ionizing radiation	"greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Hr^rh-bmh/Hr^rh-bmh Genetic Background: involves: C57BL/6JRj * CBA/JRj
MP:0004100	abnormal spinal cord interneuron morphology	"malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli2^tm1Alj/Gli2^tm1Alj,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0004175	telangiectases	"vascular lesion formed by dilation of a group of small blood vessels" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004194	abnormal kidney pelvis morphology	"any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0004199	enlarged fetal size	"larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Ptch1^dl/Ptch1^tm1Zim Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J
MP:0004208	basal cell carcinoma	"a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2^tm1Pmc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129T2/SvEms * FVB/N
MP:0004310	small otic vesicle	"reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0004342	scapular bone foramen	"presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0004449	absent presphenoid bone	"absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0004460	alisphenoid bone hypoplasia	"underdevelopment or reduced size in either of the broad curved wing like expanses on each side of the sphenoid bone in adults, usually due to reduced cell number; this bone may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0004462	small basisphenoid bone	"reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0004478	testicular teratoma	"neoplasms found in the testis that are composed of multiple tissue types; includes types not normally found in tesis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004500	increased incidence of ionizing radiation-induced tumors	"higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: involves: 129/Sv * CD-1
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129T2/SvEms * FVB/N
MP:0004733	abnormal thoracic cavity	"any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0004754	abnormal kidney collecting duct	"any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre)1Bfri/0 Genetic Background: involves: 129T2/SvEms * C57BL/6 * CBA Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre/Esr1)14Fsh/0 Genetic Background:* involves: 129T2/SvEms * FVB/N
MP:0004971	dermal hyperplasia	"overdevelopment or increased size, usually due an increased number of cells in the dermal layer of the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0004979	abnormal neuronal precursor cell number	"deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB Allelic Composition: Hhip^tm1Amc/Hhip⁺,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
MP:0004980	increased neuronal precursor cell number	"increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre)1Bfri/0 Genetic Background: involves: 129T2/SvEms * C57BL/6 * CBA Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(GFAP-cre)25Mes/0 Genetic Background: involves: 129T2/SvEms * FVB/N Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw Genetic Background: involves: 129T2/SvEms
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005157	holoprosencephaly	"presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1^tm1Zim,Stil^tm1Mku/Stil^tm1Mku Genetic Background: involves: 129/Sv
MP:0005192	increased motor neuron number	"greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli2^tm1Alj/Gli2^tm1Alj,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0005503	abnormal tendon morphology	"structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptch1^mes/Ptch1^mes Genetic Background: B6C3Fe a/a-Ptch1^mes
MP:0005657	abnormal neural plate morphology	"malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0006283	medulloblastoma	"a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: involves: 129/Sv * CD-1 Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2^tm1Pmc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 Allelic Composition: Brca2^tm1Brn/Brca2^tm1Brn,Ptch1^tm1Mps/Ptch1⁺,Trp53^tm1Tyj/Trp53⁺,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * C57BL/6 * SJL Allelic Composition: Brca2^tm1Brn/Brca2^tm1Brn,Ptch1^tm1Mps/Ptch1⁺,Trp53^tm1Tyj/Trp53^tm1Tyj,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * C57BL/6 * SJL Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Tg(Atoh1-GFP)1Jejo/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Ptch1^tm1Cklr/Ptch1⁺,Pax7^tm1(cre)Mrc/Pax7⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Ptch1^tm1Cklr/Ptch1⁺,Trp53^tm1Brn/?,Pax7^tm1(cre)Mrc/Pax7⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre)1Bfri/0 Genetic Background: involves: 129T2/SvEms * C57BL/6 * CBA Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre/Esr1)14Fsh/0 Genetic Background:* involves: 129T2/SvEms * FVB/N Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(GFAP-cre)25Mes/0 Genetic Background: involves: 129T2/SvEms * FVB/N Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J * ICR Allelic Composition: Ptch1^tm1.1Hahn/Ptch1⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006292	abnormal olfactory placode morphology	"any structural abnormality in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes" [J:62024, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0006294	absent optic vesicle	"absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0006322	abnormal perichondrium morphology	"any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", J:117033, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy,Ptch1^tm1Yy/Ptch1^tm1.1Yy,Tg(Col2a1-cre)1Bhr/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0006341	small first branchial arch	"reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hhip^tm1Amc/Hhip⁺,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
MP:0006343	enlarged first branchial arch	"increased size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
MP:0006344	small second branchial arch	"reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0008082	increased single-positive T cell number	"greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008146	asymmetric rib-sternum attachment	"loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0008190	decreased transitional stage B cell number	"reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008210	increased mature B cell number	"greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ptch1^tm1Yy/Ptch1^tm1Yy,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: 129 * C57BL/6 * FVB/NJ
MP:0008273	abnormal intramembranous bone ossification	"anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0008395	abnormal osteoblast differentiation	"atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008784	craniorachischisis	"congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0008785	abnormal sternal manubrium morphology	"any structural anomaly in the cranial most segment of the sternum" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0008914	enlarged cerebellum	"increased size of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre)1Bfri/0 Genetic Background: involves: 129T2/SvEms * C57BL/6 * CBA Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(Atoh1-cre/Esr1)14Fsh/0 Genetic Background:* involves: 129T2/SvEms * FVB/N
MP:0009743	preaxial polydactyly	"duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0009882	absent palatal shelf	"absence of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0009883	palatal shelf hypoplasia	"reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0010029	abnormal basicranium morphology	"any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0010279	increased gastrointestinal tumor incidence	"greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0010300	increased skin tumor incidence	"greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010308	decreased tumor latency	"earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ptch1^tm1Mps/Ptch1⁺,Ptch2^tm1Pmc/Ptch2^tm1Pmc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010642	absent third branchial arch	"absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0010643	absent fourth branchial arch	"absence of the structure of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0010939	abnormal mandibular prominence morphology		Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0010940	abnormal maxillary prominence morphology		Show Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Il2rg^tm1Sug/Y Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mtss1^tm1Pla/Mtss1^tm1Pla,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Disp1^icb/Disp1^icb,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1^tm1Zim,Stil^tm1Mku/Stil^tm1Mku Genetic Background: involves: 129/Sv Allelic Composition: Dync2h1^lln/Dync2h1^lln,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gli2^tm1Alj/Gli2^tm1Alj,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster Allelic Composition: Gli1^tm1Alj/Gli1^tm1Alj,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster Allelic Composition: Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv 129X1/SvJ Swiss Webster Allelic Composition: Kif7^maki/Kif7^maki,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Hlxb9-GFP)1Tmj/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N Allelic Composition: Ptch1^wig/Ptch1^wig Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ Allelic Composition: Ptch1^tm1.1Hahn/Ptch1^tm1.1Hahn Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB Allelic Composition: Ptch1^tm1Zim/Ptch1^tm1Zim Genetic Background: involves: 129/Sv
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J
MP:0011712	absent osteoblast differentiation		Show Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy,Ptch1^tm1Yy/Ptch1^tm1.1Yy,Tg(Col2a1-cre)1Bhr/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0011934	abnormal branching involved in pancreas development	"any anomaly in the process in which the branches of the developing pancreas are generated and organized" [GO:0061114]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012136	absent forebrain	"absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]	Show Allelic Composition: Ptch1^tm1.1Bjw/Ptch1^tm1.1Bjw Genetic Background: involves: 129T2/SvEms * C57BL/6J
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0012525	abnormal rhombic lip morphology	"any structural anomaly of the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system" [MGI:anna]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tg(GFAP-cre)25Mes/0 Genetic Background: involves: 129T2/SvEms * FVB/N
MP:0012675	enlarged floor plate	"increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]	Show Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc,Ptch1^tm1Mps/Ptch1^tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
MP:0013945	abnormal elbow joint morphology		Show Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy,Ptch1^tm1Yy/Ptch1^tm1.1Yy,Tg(Col2a1-cre)1Bhr/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0014100	increased chondrocyte proliferation	"increased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0020137	decreased bone mineralization	"decrease in the rate at which minerals are deposited into bone" []	Show Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy,Ptch1^tm1Yy/Ptch1^tm1.1Yy,Tg(Col2a1-cre)1Bhr/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0030137	abnormal upper incisor morphology	"any structural anomaly of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]	Show Allelic Composition: Lrp4^tm2Her/Lrp4^tm2Her Genetic Background: involves: 129S/SvEv
MP:0030220	mandibular cysts	"presence of saccular lesions lined with epithelium and contained within pathologically formed cavities in the mandible" [MGI:anna]	Show Allelic Composition: Ptch1^tm1Zim/Ptch1⁺ Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) Allelic Composition: Ptch1^tm1Kmmt/Ptch1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0030284	short mandibular coronoid process	"length reduction or truncation of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna]	Show Allelic Composition: Ptch1^dl/Ptch1^dl Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0030285	mandibular coronoid process hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna]	Show Allelic Composition: Ptch1^dl/Ptch1^tm1Mps Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

ENSMUSG00000021466