ENSDARG00000095859


Danio rerio

Features
Gene ID: ENSDARG00000095859
  
Biological name :ptch1
  
Synonyms : patched 1 / ptch1
  
Possible biological names infered from orthology : Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA. / Q13635 / Q61115
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 29963024
Gene end: 29966285
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000125042
swissprot - F8W5M6
ZFIN ID - ZDB-GENE-980526-196
Ensembl - ENSDARG00000095859
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTCH1ENSGALG00000012620Gallus gallus
 PTCH1ENSG00000185920Homo sapiens
 Ptch1ENSMUSG00000021466Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptch1 / patched 1 / Q13635* / Q61115* / Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA.*ENSDARG00000016404100
ptch2 / patched 2 / 2 * / O35595* / Q9Y6C5*ENSDARG0000005502653
NPC1L1 / NPC1 like intracellular cholesterol transporter 1 / Q9UHC9*ENSDARG0000009955823
npc1 / Niemann-Pick disease, type C1 / O15118* / O35604* / Niemann-Pick C1 protein * / NPC intracellular cholesterol transporter 1*ENSDARG0000001718013
ptchd4 / Q5RIV7 / patched domain containing 4 / Q6ZW05* / Mus musculus patched domain containing 4 (Ptchd4), transcript variant 1, mRNA.*ENSDARG0000000824913
ptchd1 / patched domain containing 1 / Q14B62* / Q96NR3* / Patched domain-containing protein 1 *ENSDARG0000001806611
si:ch211-250m6.7 / PTCHD3* / Q0EEE2* / Q3KNS1* / patched domain containing 3*ENSDARG000000688749
CR792422.1 / PTCHD3* / Q3KNS1* / patched domain containing 3*ENSDARG000000100750


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001957 intramembranous ossification IMP
 biological_processGO:0010002 cardioblast differentiation IGI
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IMP
 biological_processGO:0048635 negative regulation of muscle organ development IGI
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer cell increased amount , abnormal
Show

 ZFA:0000035 lens lens degenerate , abnormal
lens quality , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
Show

 ZFA:0000040 median fin fold median fin fold epithelium undulate , abnormal
median fin fold increased size , abnormal
median fin fold undulate , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer cell increased amount , abnormal
Show

 ZFA:0000152 retina retina increased size , abnormal
retina cell increased amount , abnormal
retina structure , abnormal
retina dorsal region disorganized , abnormal
Show

 ZFA:0000155 somite somite shape , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
inner ear structure , abnormal
inner ear morphology , abnormal
inner ear quality , abnormal
Show

 ZFA:0000250 opercle opercle malformed , abnormal
opercle postero-ventral margin increased length , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal aplastic , abnormal
Show

 ZFA:0001029 inner limiting membrane inner limiting membrane disorganized , abnormal
inner limiting membrane broken , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism sterile , abnormal
whole organism dwarf-like , abnormal
whole organism dead , abnormal
Show

 ZFA:0001114 head head increased volume , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin increased size , abnormal
pectoral fin undulate , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage osteoblast increased amount , abnormal
Show

 ZFA:0001238 iris iris increased size , abnormal
Show

 ZFA:0001283 pupil pupil decreased size , abnormal
Show

 ZFA:0001289 ciliary marginal zone ciliary marginal zone neuronal stem cell increased amount , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage physical object quality , abnormal
ceratohyal cartilage ossified , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage physical object quality , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer cell increased amount , abnormal
retinal outer nuclear layer photoreceptor cell displaced to ciliary marginal zone , abnormal
Show

 ZFA:0001672 dorsolateral septum dorsolateral septum aplastic , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell increased amount , abnormal
slow muscle cell mislocalised , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell increased amount , abnormal
fast muscle cell mislocalised , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell mislocalised , abnormal
Show

 ZFA:0009280 Muller cell Muller cell axon terminus physical object quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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