ENSDARG00000055026


Danio rerio

Features
Gene ID: ENSDARG00000055026
  
Biological name :ptch2
  
Synonyms : patched 2 / ptch2
  
Possible biological names infered from orthology : 2 / O35595 / Q9Y6C5
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 33969212
Gene end: 33993636
  
Corresponding Affymetrix probe sets: Dr.532.1.S1_at (Zebrafish Array)   NM_130988_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000121513
Ensembl peptide - ENSDARP00000071771
NCBI entrez gene - 30181     See in Manteia.
RefSeq - NM_130988
RefSeq Peptide - NP_571063
swissprot - F1R837
swissprot - F1Q8S0
ZFIN ID - ZDB-GENE-980526-44
Ensembl - ENSDARG00000055026
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTCH2ENSGALG00000010133Gallus gallus
 PTCH2ENSG00000117425Homo sapiens
 2 ENSMUSG00000028681Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptch1 / patched 1 / Q13635* / Q61115* / Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA.*ENSDARG0000001640456
npc1 / Niemann-Pick disease, type C1 / O15118* / O35604* / Niemann-Pick C1 protein * / NPC intracellular cholesterol transporter 1*ENSDARG0000001718017
NPC1L1 / NPC1 like intracellular cholesterol transporter 1 / Q9UHC9*ENSDARG0000009955812
si:ch211-250m6.7 / PTCHD3* / Q0EEE2* / Q3KNS1* / patched domain containing 3*ENSDARG0000006887412
ptchd4 / Q5RIV7 / patched domain containing 4 / Q6ZW05* / Mus musculus patched domain containing 4 (Ptchd4), transcript variant 1, mRNA.*ENSDARG0000000824910
ptchd1 / patched domain containing 1 / Q14B62* / Q96NR3* / Patched domain-containing protein 1 *ENSDARG0000001806610
CR792422.1 / PTCHD3* / Q3KNS1* / patched domain containing 3*ENSDARG000000100759
ptch1 / patched 1 / Q13635* / Q61115* / Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA.*ENSDARG000000958594


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR003392  Protein patched/dispatched
 IPR004766  Transmembrane receptor, patched


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008158 hedgehog receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000003 adaxial cell adaxial cell dispersed , abnormal
Show

 ZFA:0000008 brain brain morphology , abnormal
Show

 ZFA:0000028 heart primordium heart primordium cardiac muscle myoblast increased amount , abnormal
Show

 ZFA:0000029 hindbrain hindbrain axial region increased amount , abnormal
hindbrain axial region increased distribution , abnormal
Show

 ZFA:0000035 lens lens displaced , abnormal
lens aplastic , abnormal
Show

 ZFA:0000047 peripheral olfactory organ peripheral olfactory organ aplastic , abnormal
Show

 ZFA:0000050 optic vesicle optic vesicle decreased size , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased amount , abnormal
otic vesicle cytoplasm absent , abnormal
Show

 ZFA:0000075 spinal cord spinal cord increased distribution , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye curved lateral , abnormal
eye mislocalised medially , abnormal
eye degenerate , abnormal
eye structure , abnormal
eye protruding into diencephalon , abnormal
Show

 ZFA:0000137 optic stalk optic stalk increased size , abnormal
optic stalk mislocalised , abnormal
optic stalk kinked , abnormal
optic stalk distended , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium protruding , abnormal
retinal pigmented epithelium displaced , abnormal
Show

 ZFA:0000152 retina retina protruding , abnormal
retina displaced , abnormal
Show

 ZFA:0000155 somite somite U-shaped , abnormal
somite muscle pioneer increased amount , abnormal
somite slow muscle cell increased amount , abnormal
somite straight angle to somite , abnormal
somite epithelium irregular spatial pattern , abnormal
somite orientation somite , abnormal
somite obtuse angle to somite , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000445 optic tectum optic tectum proliferative , abnormal
Show

 ZFA:0000555 opercular flap opercular flap osteoclast differentiated , abnormal
Show

 ZFA:0000862 caudal fin skeleton caudal fin skeleton osteoclast differentiated , abnormal
Show

 ZFA:0001056 myotome myotome cytoplasm absent , abnormal
myotome has fewer parts of type fast muscle cell , abnormal
myotome has extra parts of type slow muscle cell , abnormal
myotome central region mislocalised , abnormal
myotome skeletal muscle cell differentiation process quality , abnormal
Show

 ZFA:0001066 neural arch neural arch osteoclast differentiated , abnormal
Show

 ZFA:0001071 presumptive neural retina presumptive neural retina decreased size , abnormal
Show

 ZFA:0001086 muscle pioneer muscle pioneer increased amount , abnormal
muscle pioneer mislocalised , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism curved , abnormal
whole organism decreased size , abnormal
Show

 ZFA:0001135 neural tube neural tube cytoplasm absent , abnormal
neural tube cilium spatial pattern , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased size , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage osteoblast increased amount , abnormal
Meckels cartilage osteoclast differentiated , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton malformed , abnormal
Show

 ZFA:0001229 pharyngeal arch 7 skeleton pharyngeal arch 7 skeleton osteoclast differentiated , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch protruding , abnormal
ventral mandibular arch proliferative , abnormal
Show

 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage physical object quality , abnormal
ceratohyal cartilage ossified , abnormal
ceratohyal cartilage disorganized , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage physical object quality , abnormal
hyosymplectic cartilage ossified , abnormal
Show

 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer protruding , abnormal
Show

 ZFA:0005145 muscle muscle morphology , abnormal
Show

 ZFA:0005491 optic furrow optic furrow open , abnormal
Show

 ZFA:0009090 pigment cell pigment cell decreased amount , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell increased amount , abnormal
slow muscle cell mislocalised , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell increased amount , abnormal
fast muscle cell mislocalised , abnormal
fast muscle cell decreased amount , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon disorganized , abnormal
retinal ganglion cell axon ipsilateral to eye , abnormal
retinal ganglion cell cell body mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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