ENSGALG00000012620


Gallus gallus

Features
Gene ID: ENSGALG00000012620
  
Biological name :PTCH1
  
Synonyms : protein patched homolog 1 / PTCH1
  
Possible biological names infered from orthology : Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA. / patched 1 / Q13635 / Q61115
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 41772281
Gene end: 41834833
  
Corresponding Affymetrix probe sets: Gga.17559.1.S1_at (Chicken Array)   Gga.474.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020572
Ensembl peptide - ENSGALP00000058358
Ensembl peptide - ENSGALP00000053107
NCBI entrez gene - 395806     See in Manteia.
RefSeq - NM_204960
RefSeq - XM_015280248
RefSeq Peptide - NP_990291
swissprot - A0A1D5PZE7
swissprot - A0A1D5PJW0
swissprot - F1NYG9
Ensembl - ENSGALG00000012620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptch1ENSDARG00000095859Danio rerio
 ptch1ENSDARG00000016404Danio rerio
 PTCH1ENSG00000185920Homo sapiens
 Ptch1ENSMUSG00000021466Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTCH2 / patched 2 / 2 * / O35595* / Q9Y6C5*ENSGALG0000001013349
NPC1 / NPC intracellular cholesterol transporter 1 / O15118* / O35604* / Niemann-Pick C1 protein *ENSGALG0000001503017
PTCHD3 / patched domain containing 3 / Q0EEE2* / Q3KNS1*ENSGALG0000002334713
PTCHD1 / patched domain containing 1 / Q14B62* / Q96NR3* / Patched domain-containing protein 1 *ENSGALG0000001635810
PTCHD4 / patched domain-containing protein 4 / Q6ZW05* / patched domain containing 4* / Mus musculus patched domain containing 4 (Ptchd4), transcript variant 1, mRNA.*ENSGALG0000001672610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR003392  Protein patched/dispatched
 IPR004766  Transmembrane receptor, patched


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001709 cell fate determination IEA
 biological_processGO:0001841 neural tube formation IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0008589 regulation of smoothened signaling pathway IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0009957 epidermal cell fate specification IEA
 biological_processGO:0010157 response to chlorate IEA
 biological_processGO:0010875 positive regulation of cholesterol efflux IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021532 neural tube patterning IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0021997 neural plate axis specification IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0035108 limb morphogenesis IEA
 biological_processGO:0035137 hindlimb morphogenesis IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0040015 negative regulation of multicellular organism growth IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043616 keratinocyte proliferation IEA
 biological_processGO:0045606 positive regulation of epidermal cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051782 negative regulation of cell division IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060603 mammary gland duct morphogenesis IEA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IEA
 biological_processGO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning IEA
 biological_processGO:0061005 cell differentiation involved in kidney development IEA
 biological_processGO:0061053 somite development IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072203 cell proliferation involved in metanephros development IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005113 patched binding IEA
 molecular_functionGO:0005119 smoothened binding IEA
 molecular_functionGO:0008158 hedgehog receptor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0015485 cholesterol binding IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0097108 hedgehog family protein binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Ligand-receptor interactions
Hedgehog on state
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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