ENSGALG00000015030


Gallus gallus

Features
Gene ID: ENSGALG00000015030
  
Biological name :NPC1
  
Synonyms : NPC1 / NPC intracellular cholesterol transporter 1
  
Possible biological names infered from orthology : Niemann-Pick C1 protein / O15118 / O35604
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 103346605
Gene end: 103372094
  
Corresponding Affymetrix probe sets: Gga.8079.2.S1_at (Chicken Array)   GgaAffx.24573.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058863
Ensembl peptide - ENSGALP00000024194
NCBI entrez gene - 421076     See in Manteia.
RefSeq - XM_419162
RefSeq - XM_004939783
RefSeq - XM_004939784
swissprot - F1NQT4
swissprot - A0A1L1RJD2
Ensembl - ENSGALG00000015030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npc1ENSDARG00000017180Danio rerio
 NPC1ENSG00000141458Homo sapiens
 Npc1ENSMUSG00000024413Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTCH1 / protein patched homolog 1 / Q13635* / Q61115* / patched 1* / Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA.*ENSGALG0000001262019
PTCH2 / patched 2 / 2 * / O35595* / Q9Y6C5*ENSGALG0000001013316
PTCHD3 / patched domain containing 3 / Q0EEE2* / Q3KNS1*ENSGALG0000002334716
PTCHD1 / patched domain containing 1 / Q14B62* / Q96NR3* / Patched domain-containing protein 1 *ENSGALG0000001635812
PTCHD4 / patched domain-containing protein 4 / Q6ZW05* / patched domain containing 4* / Mus musculus patched domain containing 4 (Ptchd4), transcript variant 1, mRNA.*ENSGALG0000001672611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR003392  Protein patched/dispatched
 IPR004765  NPC1-like
 IPR032190  Niemann-Pick C1, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0016242 negative regulation of macroautophagy IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0031579 membrane raft organization IEA
 biological_processGO:0033344 cholesterol efflux IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0090150 establishment of protein localization to membrane IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005319 lipid transporter activity IEA
 molecular_functionGO:0015485 cholesterol binding IEA


Pathways (from Reactome)
Pathway description
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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