Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000182	increased circulating LDL cholesterol level	"greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^tm1.1Apl/Npc1^tm1.2Apl,Tg(Pcp2-cre)2Mpin/0 Genetic Background: B6.Cg-Npc1^tm1.1Apl/Npc1^tm1.2Apl Tg(Pcp2-cre)2Mpin Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: App^tm1Dbo/App^tm1Dbo,Npc1^m1N/Npc1^m1N Genetic Background: C.Cg-App^tm1Dbo Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N
MP:0000781	reduced size of corpus callosum	"smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0000819	abnormal olfactory bulb morphology	"malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0000848	abnormal pons	"malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0000867	abnormal anterior vermis	"malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0000869	abnormal posterior vermis	"malformation in the posterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0000876	Purkinje cell degeneration	"a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^m1N/Npc1^m1N,Npc2^tm1Plob/Npc2^tm1Plob Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^tm1.1Apl/Npc1^tm1.2Apl,Tg(Pcp2-cre)2Mpin/0 Genetic Background: B6.Cg-Npc1^tm1.1Apl/Npc1^tm1.2Apl Tg(Pcp2-cre)2Mpin Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: App^tm1Dbo/App^tm1Dbo,Npc1^m1N/Npc1^m1N Genetic Background: C.Cg-App^tm1Dbo Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1*)5Amc
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^m1N/Npc1^m1N,Npc2^tm1Plob/Npc2^tm1Plob Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: App^tm1Dbo/App^tm1Dbo,Npc1^m1N/Npc1^m1N Genetic Background: C.Cg-App^tm1Dbo Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0000952	abnormal CNS glia	"anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0001092	abnormal trigeminal ganglion morphology	"malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0001119	abnormal female reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001131	abnormal ovarian follicles	"malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001132	absent mature ovarian follicles	"failure of ovarian follicle differentiation" [J:35782]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001134	absent corpora lutea	"missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001179	thicker alveolar septa		Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^m1N/Npc1^m1N,Npc2^tm1Plob/Npc2^tm1Plob Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Npc1^tm1.2Apl/Npc1^tm1.2Apl Genetic Background: C57BL/6-Npc1^tm1.2Apl Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: App^tm1Dbo/App^tm1Dbo,Npc1^m1N/Npc1^m1N Genetic Background: C.Cg-App^tm1Dbo Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129/Ola * BALB/c
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^tm1.1Apl/Npc1^tm1.2Apl,Tg(Pcp2-cre)2Mpin/0 Genetic Background: B6.Cg-Npc1^tm1.1Apl/Npc1^tm1.2Apl Tg(Pcp2-cre)2Mpin Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^{tm1b(EUCOMM)Hmgu}/Npc1⁺ Genetic Background: C57BL/6N-Npc1^{tm1b(EUCOMM)Hmgu}/H
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^tm1.1Apl/Npc1^tm1.2Apl,Tg(Pcp2-cre)2Mpin/0 Genetic Background: B6.Cg-Npc1^tm1.1Apl/Npc1^tm1.2Apl Tg(Pcp2-cre)2Mpin Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl Allelic Composition: App^tm1Dbo/App^tm1Dbo,Npc1^m1N/Npc1^m1N Genetic Background: C.Cg-App^tm1Dbo Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J
MP:0001458	abnormal object recognition memory	"defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0001750	increased circulating follicle stimulating hormone level	"higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001751	increased circulating luteinizing hormone level	"higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001866	nasal inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129/Ola * BALB/c Allelic Composition: Npc1^tm1.2Apl/Npc1^tm1.2Apl Genetic Background: C57BL/6-Npc1^tm1.2Apl
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^m1N/Npc1^m1N,Npc2^tm1Plob/Npc2^tm1Plob Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(CAG-RAB9A)500Repa/0 Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Npc1^m1N/Npc1^m1N,Nr1h2^tm1Djm/Nr1h2^tm1Djm Genetic Background: involves: 129S6/SvEvTac * BALB/c Allelic Composition: Abca1^tm1Wpfl/Abca1^tm1Wpfl,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6 Allelic Composition: Npc1^tm1.2Apl/Npc1^tm1.2Apl Genetic Background: C57BL/6-Npc1^tm1.2Apl Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: App^tm1Dbo/App^tm1Dbo,Npc1^m1N/Npc1^m1N Genetic Background: C.Cg-App^tm1Dbo Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^m1N/Npc1^m1N,Npc2^tm1Plob/Npc2^tm1Plob Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0002133	abnormal respiratory system physiology	"anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1*)5Amc
MP:0002175	low brain weight	"lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J
MP:0002275	abnormal type II pneumocyte morphology	"any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0002446	abnormal macrophage morphology	"anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0002783	abnormal ovarian secretion	"malfunction of the production and/or release of hormones from ovarian tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Jak2^tm1Kf/Jak2^tm1Kf Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003172	abnormal lysosome physiology	"ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0003191	abnormal cellular cholesterol metabolism	"impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0003345	decreased number of ribs	"fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Npc1^{tm1b(EUCOMM)Hmgu}/Npc1⁺ Genetic Background: C57BL/6N-Npc1^{tm1b(EUCOMM)Hmgu}/H
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: App^tm1Dbo/App^tm1Dbo,Npc1^m1N/Npc1^m1N Genetic Background: C.Cg-App^tm1Dbo Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0003690	abnormal glial cell physiology	"anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npc1^m1N/Npc1^m1N,Tlr4^tm1Aki/Tlr4^tm1Aki Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003691	abnormal microglial cell function	"anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C57BL/6 * CBA
MP:0003947	abnormal cholesterol level	"anomaly in the concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J
MP:0003982	increased cholesterol level	"greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c Allelic Composition: Abca1^tm1Wpfl/Abca1^tm1Wpfl,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Npc1^tm1.1Apl/Npc1^tm1.2Apl,Tg(Pcp2-cre)2Mpin/0 Genetic Background: B6.Cg-Npc1^tm1.1Apl/Npc1^tm1.2Apl Tg(Pcp2-cre)2Mpin Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0004007	abnormal lung vasculature	"malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0004163	abnormal adenophysis morphology	"any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0004542	impaired acrosome reaction	"abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0004777	abnormal phospholipid level	"anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(CAG-RAB9A)500Repa/0 Genetic Background: involves: BALB/c * C57BL/6 * CBA
MP:0004778	increased foam cell number	"greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0004781	abnormal surfactant composition	"anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0004856	decreased ovary weight	"reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0004894	uterus atrophy	"wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0005121	decreased circulating prolactin level	"less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0005138	decreased prolactin level	"less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0005145	increased circulating VLDL cholesterol level	"greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0005236	abnormal olfactory nerve morphology	"anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0005278	abnormal cholesterol homeostasis	"anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]	Show Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0005319	abnormal enzyme/ coenzyme level	"altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0005499	abnormal olfactory system morphology	"anomalous structure of the organs involved in smell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0005544	corneal deposits	"accumulation of minerals, proteins, or other anomalous substances on the cornea" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0005578	teratozoospermia	"presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J
MP:0005630	increased lung weight	"greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0006092	abnormal olfactory neuron morphology	"malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0008245	abnormal alveolar macrophage morphology	"any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008257	thin myometrium	"reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008258	thin endometrium	"reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008267	abnormal hippocampus CA3 region morphology		Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0008332	decreased lactotroph cell number	"reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008365	adenohypophysis hypoplasia	"underdevelopment or reduced size, usually due to a reduced cell number, of the anterior lobe of the pituitary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008544	impaired olfaction	"reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0008545	absent sperm flagella	"mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008547	abnormal neocortex morphology	"any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0008570	lipidosis	"abnormal fat metabolism with increased accumulation of specific lipids in tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008572	abnormal Purkinje cell dendrite morphology	"any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0008789	abnormal olfactory epithelium morphology	"any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0008868	abnormal granulosa cell morphology	"any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008869	anovulation	"complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0008916	abnormal astrocyte physiology	"any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^tm1.1Apl/Npc1^tm1.2Apl,Tg(Pcp2-cre)2Mpin/0 Genetic Background: B6.Cg-Npc1^tm1.1Apl/Npc1^tm1.2Apl Tg(Pcp2-cre)2Mpin Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0009009	absent estrous cycle	"failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0009081	thin uterus	"reduced thickness or depth of the female muscular organ of gestation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0009096	decreased endometrial gland number	"fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0009230	abnormal sperm head morphology	"any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0009234	absent sperm head	"absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0009287	decreased abdominal fat pad weight	"less than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0009359	endometrium atrophy	"wasting of the endometrium due to injury or disease resulting in reduced size" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0009363	abnormal secondary ovarian follicle morphology	"any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0009587	abnormal plasma membrane sphingolipid content	"altered amounts of the phospholipids found especially in, but not limited to, the cell membrane of nerve tissue that yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J
MP:0009588	increased plasma membrane sphingolipid content	"abnormal accumulation of the phospolipids found especially in, but not limited to, the cell membrane of nerve tissue that yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J
MP:0009589	sphingomyelinosis	"the abnormal accumulation of sphingomyelin in the plasma membrane of cells of the nervous tissue, liver and spleen, usually due to sphingomyelinase deficiency" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0009823	abnormal sphingomyelin level	"deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N
MP:0009841	foam cell reticulosis	"an increase in cells with a vacuolated appearance due to abnormal deposition and retention of lipoproteins and derived from or related to the group of cells having the ability to take up and sequester inert particles and vital dyes, including macrophages and macrophage precursors, specialized endothelial cells lining the sinusoids of the liver, spleen, and bone marrow, and macrophages of lymphatic tissue and fibroblasts of bone marrow" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^tm1.2Apl Genetic Background: B6.Cg-Npc1^m1N/Npc1^tm1.2Apl Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0010026	decreased liver cholesterol level	"less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0010027	increased liver cholesterol level	"greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129/Ola * BALB/c Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^m1N/Npc1^m1N,Npc2^tm1Plob/Npc2^tm1Plob Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Npc1^spm/Npc1^spm Genetic Background: C57BLKS/J-Npc1^spm/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: Npc1^tm1Mbjg/Npc1^tm1Mbjg Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0010047	axonal spheroids	"focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]	Show Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0010161	decreased brain cholesterol level	"less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c Allelic Composition: Abca1^tm1Wpfl/Abca1^tm1Wpfl,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0010162	increased brain cholesterol level	"greater than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: App^tm1Dbo/App^tm1Dbo,Npc1^m1N/Npc1^m1N Genetic Background: C.Cg-App^tm1Dbo Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(PRNP-APPSweInd)8Dwst/0 Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^tm1.1Dso/Npc1⁺ Genetic Background: B6.129-Npc1^tm1.1Dso Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(CAG-cre/Esr1)5Amc Allelic Composition:* Npc1^m1N/Npc1^tm1.1Apl,Tg(Syn1-cre)671Jxm/0 Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm
MP:0010181	decreased susceptibility to weight loss	"smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N,Tg(CAG-RAB9A)500Repa/0 Genetic Background: involves: BALB/c * C57BL/6 * CBA
MP:0010762	abnormal microglial cell activation	"any anomaly in change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0010813	abnormal alveolar lamellar body morphology	"any structural anomaly of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0010815	enlarged alveolar lamellar bodies	"increased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0010831	partial lethality	"the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/cNctr-Npc1^m1N/J
MP:0010998	pulmonary alveolar proteinosis	"abnormal intra-alveolar accumulation of an amorphous, largely cell-free, surfactant-like lipoproteinaceous material that is not easily cleared from the lungs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Npc1^{tm1b(EUCOMM)Hmgu}/Npc1⁺ Genetic Background: C57BL/6N-Npc1^{tm1b(EUCOMM)Hmgu}/H
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0012230	abnormal sphingolipid level		Show Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0012231	abnormal ganglioside level		Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0012232	abnormal ceramide level		Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: B6.C-Npc1^m1N Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso
MP:0013203	abnormal primary cilium morphology	"any structural anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors" [GO:0072372]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N
MP:0020448	increased microglial cell activation	"increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]	Show Allelic Composition: Npc1^nmf164/Npc1^nmf164 Genetic Background: C57BL/6J-Npc1^nmf164/J Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: BALB/c-Npc1^m1N Allelic Composition: Npc1^tm1.1Dso/Npc1^tm1.1Dso Genetic Background: B6.129-Npc1^tm1.1Dso

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

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