ENSMUSG00000020964


Mus musculus

Features
Gene ID: ENSMUSG00000020964
  
Biological name :Sel1l
  
Synonyms : Q9Z2G6 / Sel1l / sel-1 suppressor of lin-12-like (C. elegans)
  
Possible biological names infered from orthology : Q9UBV2 / SEL1L ERAD E3 ligase adaptor subunit
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D3
Gene start: 91806043
Gene end: 91849157
  
Corresponding Affymetrix probe sets: 10401900 (MoGene1.0st)   1425187_at (Mouse Genome 430 2.0 Array)   1425188_s_at (Mouse Genome 430 2.0 Array)   1430692_a_at (Mouse Genome 430 2.0 Array)   1436774_at (Mouse Genome 430 2.0 Array)   1453559_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021347
Ensembl peptide - ENSMUSP00000129384
Ensembl peptide - ENSMUSP00000136087
NCBI entrez gene - 20338     See in Manteia.
MGI - MGI:1329016
RefSeq - NM_001039089
RefSeq - NM_011344
RefSeq Peptide - NP_001034178
RefSeq Peptide - NP_035474
swissprot - Q9Z2G6
swissprot - Q6GTY4
swissprot - J3QJX3
Ensembl - ENSMUSG00000020964
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sel1lENSDARG00000004581Danio rerio
 SEL1LENSGALG00000010581Gallus gallus
 SEL1LENSG00000071537Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
2 / Q3V172 / Sel1l2 / Q5TEA6* / SEL1L2 ERAD E3 ligase adaptor subunit*ENSMUSG0000007476441
3 / Q80TS8 / Sel1l3 / Q68CR1* / SEL1L family member 3*ENSMUSG0000002918922


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR006597  Sel1-like repeat
 IPR013806  Kringle-like fold
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0009306 protein secretion IMP
 biological_processGO:0030970 retrograde protein transport, ER to cytosol ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0036503 ERAD pathway ISS
 cellular_componentGO:0000839 Hrd1p ubiquitin ligase ERAD-L complex ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Hedgehog ligand biogenesis
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0009147 abnormal pancreatic acinar cell physiology "any functional anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0009164 exocrine pancreas atrophy "wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N

 MP:0009179 abnormal pancreatic alpha cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065]
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0013139 moribund "in terminal decline and approaching death; lacking vitality or vigor and becoming unresponsive" [MGI:Ahmad_Retha]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0013220 increased pancreas apoptosis "increase in the number of cells of the pancreas undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002633 Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*  / reaction / complex
 ENSMUSG00000018442 Derl2 / Q8BNI4 / Derlin-2 / Q9GZP9*  / complex
 ENSMUSG00000040462 Os9 / Q8K2C7 / Protein OS-9 / Q13438* / OS9, endoplasmic reticulum lectin*  / complex / reaction
 ENSMUSG00000020311 Erlec1 / Q8VEH8 / Endoplasmic reticulum lectin 1 / Q96DZ1*  / complex / reaction
 ENSMUSG00000024807 Syvn1 / synovial apoptosis inhibitor 1, synoviolin / Q86TM6* / synoviolin 1*  / complex
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex






 

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