ENSMUSG00000024807


Mus musculus

Features
Gene ID: ENSMUSG00000024807
  
Biological name :Syvn1
  
Synonyms : synovial apoptosis inhibitor 1, synoviolin / Syvn1
  
Possible biological names infered from orthology : Q86TM6 / synoviolin 1
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 6046576
Gene end: 6053712
  
Corresponding Affymetrix probe sets: 10460706 (MoGene1.0st)   1428070_at (Mouse Genome 430 2.0 Array)   1443609_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025723
Ensembl peptide - ENSMUSP00000121885
Ensembl peptide - ENSMUSP00000118698
Ensembl peptide - ENSMUSP00000114960
Ensembl peptide - ENSMUSP00000114843
NCBI entrez gene - 74126     See in Manteia.
MGI - MGI:1921376
RefSeq - XM_006531850
RefSeq - NM_001164709
RefSeq - NM_028769
RefSeq Peptide - NP_083045
RefSeq Peptide - NP_001158181
swissprot - D3Z1Y1
swissprot - E9QQ99
swissprot - D3YZH4
swissprot - A0A0R4J1R1
Ensembl - ENSMUSG00000024807
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syvn1ENSDARG00000017842Danio rerio
 SYVN1ENSG00000162298Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Amfr / Q9R049 / E3 ubiquitin-protein ligase AMFR / Q9UKV5* / autocrine motility factor receptor*ENSMUSG0000003175119
Q5SWK7 / Rnf145 / ring finger protein 145 / Q96MT1*ENSMUSG0000001918917
Rnf139 / ring finger protein 139 / Q8WU17*ENSMUSG0000003707512


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR032832  E3 ubiquitin-protein ligase synoviolin/Hrd1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IEA
 biological_processGO:0036503 ERAD pathway IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000836 Hrd1p ubiquitin ligase complex IEA
 cellular_componentGO:0000839 Hrd1p ubiquitin ligase ERAD-L complex IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IEA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog ligand biogenesis
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1.2Yxz/Lmnatm1.2Yxz
Genetic Background: involves: 129S * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002633 Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*  / reaction / complex
 ENSMUSG00000024807 Syvn1 / synovial apoptosis inhibitor 1, synoviolin / Q86TM6* / synoviolin 1*  / complex
 ENSMUSG00000040462 Os9 / Q8K2C7 / Protein OS-9 / Q13438* / OS9, endoplasmic reticulum lectin*  / complex / reaction
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex
 ENSMUSG00000018442 Derl2 / Q8BNI4 / Derlin-2 / Q9GZP9*  / complex
 ENSMUSG00000020964 Sel1l / Q9Z2G6 / sel-1 suppressor of lin-12-like (C. elegans) / Q9UBV2* / SEL1L ERAD E3 ligase adaptor subunit*  / complex
 ENSMUSG00000020311 Erlec1 / Q8VEH8 / Endoplasmic reticulum lectin 1 / Q96DZ1*  / complex / reaction






 

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