ENSMUSG00000031751


Mus musculus

Features
Gene ID: ENSMUSG00000031751
  
Biological name :Amfr
  
Synonyms : Amfr / E3 ubiquitin-protein ligase AMFR / Q9R049
  
Possible biological names infered from orthology : autocrine motility factor receptor / Q9UKV5
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C5
Gene start: 93971588
Gene end: 94012842
  
Corresponding Affymetrix probe sets: 10580704 (MoGene1.0st)   1450102_a_at (Mouse Genome 430 2.0 Array)   1453911_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052258
Ensembl peptide - ENSMUSP00000134924
NCBI entrez gene - 23802     See in Manteia.
MGI - MGI:1345634
RefSeq - XM_017312768
RefSeq - NM_011787
RefSeq Peptide - NP_035917
swissprot - Q3TCI2
swissprot - Q9R049
swissprot - H3BJC0
Ensembl - ENSMUSG00000031751
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 amfraENSDARG00000020218Danio rerio
 amfrbENSDARG00000105578Danio rerio
 AMFRENSGALG00000003107Gallus gallus
 AMFRENSG00000159461Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syvn1 / synovial apoptosis inhibitor 1, synoviolin / Q86TM6* / synoviolin 1*ENSMUSG0000002480718
Q5SWK7 / Rnf145 / ring finger protein 145 / Q96MT1*ENSMUSG0000001918914
Rnf139 / ring finger protein 139 / Q8WU17*ENSMUSG0000003707511


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003892  Ubiquitin system component Cue
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0009987 cellular process TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:1904288 BAT3 complex binding IEA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IBA


Pathways (from Reactome)
Pathway description
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0003046 liver cirrhosis "liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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