ENSG00000159461


Homo sapiens

Features
Gene ID: ENSG00000159461
  
Biological name :AMFR
  
Synonyms : AMFR / autocrine motility factor receptor / Q9UKV5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q13
Gene start: 56361452
Gene end: 56425538
  
Corresponding Affymetrix probe sets: 202203_s_at (Human Genome U133 Plus 2.0 Array)   202204_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455842
Ensembl peptide - ENSP00000456745
Ensembl peptide - ENSP00000473636
Ensembl peptide - ENSP00000290649
Ensembl peptide - ENSP00000456288
NCBI entrez gene - 267     See in Manteia.
OMIM - 603243
RefSeq - XM_005255890
RefSeq - NM_001144
RefSeq - NM_001323511
RefSeq - NM_001323512
RefSeq Peptide - NP_001135
RefSeq Peptide - NP_001310440
RefSeq Peptide - NP_001310441
swissprot - H3BSK3
swissprot - R4GNG2
swissprot - Q9UKV5
swissprot - H3BQM3
swissprot - H3BRK9
Ensembl - ENSG00000159461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 amfraENSDARG00000020218Danio rerio
 amfrbENSDARG00000105578Danio rerio
 AMFRENSGALG00000003107Gallus gallus
 AmfrENSMUSG00000031751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYVN1 / Q86TM6 / synoviolin 1ENSG0000016229818
Q96MT1 / RNF145 / ring finger protein 145ENSG0000014586015
Q8WU17 / RNF139 / ring finger protein 139ENSG0000017088111


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003892  Ubiquitin system component Cue
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IMP
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0036503 ERAD pathway IC
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:1904380 endoplasmic reticulum mannose trimming TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030674 protein binding, bridging IMP
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:1904288 BAT3 complex binding IPI
 molecular_functionGO:1990381 ubiquitin-specific protease binding IPI


Pathways (from Reactome)
Pathway description
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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