ENSG00000170881


Homo sapiens

Features
Gene ID: ENSG00000170881
  
Biological name :RNF139
  
Synonyms : Q8WU17 / ring finger protein 139 / RNF139
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.13
Gene start: 124474738
Gene end: 124487914
  
Corresponding Affymetrix probe sets: 209510_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000304051
Ensembl peptide - ENSP00000429836
NCBI entrez gene - 11236     See in Manteia.
OMIM - 603046
RefSeq - NM_007218
RefSeq Peptide - NP_009149
swissprot - E5RH85
swissprot - Q8WU17
Ensembl - ENSG00000170881
  
Related genetic diseases (OMIM): 144700 - Renal cell carcinoma, 144700
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf139ENSDARG00000036929Danio rerio
 RNF139ENSGALG00000032734Gallus gallus
 Rnf139ENSMUSG00000037075Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96MT1 / RNF145 / ring finger protein 145ENSG0000014586025
SYVN1 / Q86TM6 / synoviolin 1ENSG0000016229811
AMFR / Q9UKV5 / autocrine motility factor receptorENSG0000015946111


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR011016  Zinc finger, RING-CH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR025754  TRC8 N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0031396 regulation of protein ubiquitination IDA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0036503 ERAD pathway IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0060628 regulation of ER to Golgi vesicle-mediated transport IDA
 biological_processGO:0070613 regulation of protein processing IDA
 biological_processGO:1904380 endoplasmic reticulum mannose trimming TAS
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IDA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity TAS
 molecular_functionGO:0019787 ubiquitin-like protein transferase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0003745 Sporadic 
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 HP:0005584 Renal cell carcinoma "Renal cell carcinoma (also known as hypernephroma) is the most common form of kidney cancer arising from the proximal renal tubule. The tissue of origin for renal cell carcinoma is the proximal renal tubular epithelium. Renal cell carcinoma can be classified as 1) clear cell carcinoma, 2) papillary carcinoma, 3) chromophobe renal carcinoma, and 4) collecting duct carcinoma." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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