ENSG00000162298


Homo sapiens

Features
Gene ID: ENSG00000162298
  
Biological name :SYVN1
  
Synonyms : Q86TM6 / synoviolin 1 / SYVN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.1
Gene start: 65121780
Gene end: 65134533
  
Corresponding Affymetrix probe sets: 200019_s_at (Human Genome U133 Plus 2.0 Array)   225090_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431215
Ensembl peptide - ENSP00000431720
Ensembl peptide - ENSP00000436984
Ensembl peptide - ENSP00000432888
Ensembl peptide - ENSP00000432166
Ensembl peptide - ENSP00000294256
Ensembl peptide - ENSP00000302035
Ensembl peptide - ENSP00000366395
NCBI entrez gene - 84447     See in Manteia.
OMIM - 608046
RefSeq - XM_011545303
RefSeq - NM_032431
RefSeq - NM_172230
RefSeq Peptide - NP_115807
RefSeq Peptide - NP_757385
swissprot - E9PN88
swissprot - H0YCR6
swissprot - E9PK19
swissprot - E9PMA1
swissprot - Q86TM6
Ensembl - ENSG00000162298
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syvn1ENSDARG00000017842Danio rerio
 Syvn1ENSMUSG00000024807Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AMFR / Q9UKV5 / autocrine motility factor receptorENSG0000015946119
Q96MT1 / RNF145 / ring finger protein 145ENSG0000014586017
Q8WU17 / RNF139 / ring finger protein 139ENSG0000017088112


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR032832  E3 ubiquitin-protein ligase synoviolin/Hrd1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IBA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IMP
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0036503 ERAD pathway IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
 biological_processGO:1904380 endoplasmic reticulum mannose trimming TAS
 cellular_componentGO:0000836 Hrd1p ubiquitin ligase complex IEA
 cellular_componentGO:0000839 Hrd1p ubiquitin ligase ERAD-L complex IMP
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005790 smooth endoplasmic reticulum IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane NAS
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IDA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding IPI
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0051117 ATPase binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IPI


Pathways (from Reactome)
Pathway description
XBP1(S) activates chaperone genes
Hedgehog ligand biogenesis
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072849 DERL2 / Q9GZP9 / derlin 2  / complex
 ENSG00000068912 ERLEC1 / Q96DZ1 / endoplasmic reticulum lectin 1  / reaction / complex
 ENSG00000135506 OS9 / Q13438 / OS9, endoplasmic reticulum lectin  / reaction / complex
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / reaction / complex
 ENSG00000162298 SYVN1 / Q86TM6 / synoviolin 1  / complex
 ENSG00000071537 SEL1L / Q9UBV2 / SEL1L ERAD E3 ligase adaptor subunit  / complex
 ENSG00000165280 VCP / P55072 / valosin containing protein  / complex






 

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