ENSG00000071537


Homo sapiens

Features
Gene ID: ENSG00000071537
  
Biological name :SEL1L
  
Synonyms : Q9UBV2 / SEL1L / SEL1L ERAD E3 ligase adaptor subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q31.1
Gene start: 81471549
Gene end: 81533861
  
Corresponding Affymetrix probe sets: 202061_s_at (Human Genome U133 Plus 2.0 Array)   202062_s_at (Human Genome U133 Plus 2.0 Array)   202063_s_at (Human Genome U133 Plus 2.0 Array)   202064_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337053
Ensembl peptide - ENSP00000450709
Ensembl peptide - ENSP00000451144
NCBI entrez gene - 6400     See in Manteia.
OMIM - 602329
RefSeq - XM_005267989
RefSeq - NM_001244984
RefSeq - NM_005065
RefSeq - XM_005267988
RefSeq Peptide - NP_005056
RefSeq Peptide - NP_001231913
swissprot - Q9UBV2
swissprot - G3V3B3
Ensembl - ENSG00000071537
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sel1lENSDARG00000004581Danio rerio
 SEL1LENSGALG00000010581Gallus gallus
 Sel1lENSMUSG00000020964Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5TEA6 / SEL1L2 / SEL1L2 ERAD E3 ligase adaptor subunitENSG0000010125131
Q68CR1 / SEL1L3 / SEL1L family member 3ENSG0000009149022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR006597  Sel1-like repeat
 IPR013806  Kringle-like fold
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006641 triglyceride metabolic process ISS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0009306 protein secretion ISS
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway TAS
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0036503 ERAD pathway ISS
 biological_processGO:0050821 protein stabilization TAS
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:1904380 endoplasmic reticulum mannose trimming TAS
 cellular_componentGO:0000836 Hrd1p ubiquitin ligase complex TAS
 cellular_componentGO:0000839 Hrd1p ubiquitin ligase ERAD-L complex IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IDA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
ABC-family proteins mediated transport
Hedgehog ligand biogenesis
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
Defective CFTR causes cystic fibrosis
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072849 DERL2 / Q9GZP9 / derlin 2  / complex
 ENSG00000068912 ERLEC1 / Q96DZ1 / endoplasmic reticulum lectin 1  / reaction / complex
 ENSG00000135506 OS9 / Q13438 / OS9, endoplasmic reticulum lectin  / reaction / complex
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / reaction / complex
 ENSG00000162298 SYVN1 / Q86TM6 / synoviolin 1  / complex
 ENSG00000165280 VCP / P55072 / valosin containing protein  / complex






 

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